• 暨南大學附屬第二醫(yī)院,深圳市人民醫(yī)院1.體檢科;2.心內(nèi)科;3.神經(jīng)內(nèi)科,廣東深圳 518020;4.四川大學華西醫(yī)院放射科,四川成都 610041;

目的:探討血清鐵蛋白（SF）、紅細胞參數(shù)（紅細胞計數(shù)RBC、血紅蛋白HGB、紅細胞體積MCV）及炎癥標志物（白細胞計數(shù)WBC、纖維蛋白原FIG、血沉ESR）與老年代謝綜合征（MS）的關系。方法:148例老年人,依據(jù)MS組分數(shù)量多少分為MS0（無MS組分）、MS1～2（有1～2個MS組分）和MS3～5（有3～5個MS組分）三組。測定三組的血SF、空腹血糖FPG、甘油三酯TG、高密度脂蛋白膽固醇HDL-C、RBC、HGB、MCV、WBC、FIG及ESR水平,并進行分析。結果:老年女性及非吸煙老年男性MS組SF、RBC、HGB、WBC及ESR均較MS0組高。老年女性的SF、WBC與腰圍,SF、RBC、HGB、WBC與MS組分數(shù)量,SF與RBC,均呈正相關。老年非吸煙男性的WBC與TG,HGB與MS組分數(shù)量,MCV與BMI及腰圍,FIG與BMI,呈正相關。老年人HGB與DBG、TG呈正相關；與HDL-C呈負相關。結論:SF水平與MS發(fā)展相關,MS組分數(shù)量增加與聚集、超重與肥胖,可能促進體內(nèi)感染狀態(tài)。有MS的老年男女,常呈現(xiàn)低度感染狀態(tài),但同時又有一定的鐵儲備及相對穩(wěn)定的造血機能；無MS的老年男女造血功能傾向減退。老年男性吸煙者較非吸煙者易呈現(xiàn)感染狀態(tài),并具有較低的鐵儲備。

引用本文： 孫巖,李軍,李剛,鄧開鴻. 血清鐵蛋白、血紅蛋白及外周血白細胞與老年代謝綜合征關系的研究. 華西醫(yī)學, 2009, 24(3): 700-704. doi: 復制

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8. 中華醫(yī)學會糖尿病學分會代謝綜合征研究協(xié)作組.中華醫(yī)學會糖尿病學分會關于代謝綜合征的建議[J].中華糖尿病雜志,2004,12（3）:156-161..
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10. VARI IS, BALKAU B, KETTANEH A, et al. Ferritin and transferrin are associated with metabolic syndrome abnormalities and their change over time in a general population: Data from an epidemilological Study on the Insulin Resistance syndrome （DESIR）[J]. Diabetes Care,2007,30（7）:1795-1801..
11. WILLIAMS M J, POULTON R, WILLIAMS S. Relationship of serum ferritin with cardiovascular risk factors and inflammation in young men and women[J]. Atherosclerosis,2002,165（1）:179-184..
12. KIM J A, CHOI Y S, HONG J I, et al. Association of metabolic syndrome with white blood cell subtype and red blood cells[J]. Endocr J,2006,53（1）:133-139.
13. MARDI T, TOKER S, MELAMED S, et al. Increased erythropoiesis and subclinical inflammation as part of the metabolic syndrome[J]. Diabetes Res Clin Prac,2005,69（3）:249-155..
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15. SHARP D S, CURB J D, SCHATZ I J, et al. Mean red cell volume as a correlate of blood pressure[J]. Circulation,1996,93（9）:1677-1684..
  1. 1. JEHN M, CLARK JM, GUALLAR E.Serum ferritin and risk of the metabolic syndrome in U.S.adults[J].Diabetes Care,2004,27（10）:2422-2428..
  2. 2. NAGASAWA N, TAMAKOSHI K, YATSUYA H, et al.Association of white blood cell count and clustered components of metabolic syndrome in Japanese men[J].Circ J,2004,68（10）:892-897..
  3. 3. 魏玲,楊麗霞,趙穎,等.血紅蛋白含量與高血壓靶器官損傷[J].高血壓雜志,2006,14（5）:360-363..
  4. 4. 沈琪琳.老年冠心病患者血液流變學及血細胞參數(shù)的觀察[J].中國慢性病預防與控制,2000,8（6）:252,289..
  5. 5. 孫芾,趙素榮,鮑震霄.健康老年人紅細胞分布寬度的探討[J].中華老年醫(yī)學雜志,1994,13（1）:45..
  6. 6. EISENSTAEDT R, PENNINX BWJH, WOODMAN RC. Anemia in the elderly: current understanding and emerging concepts[J].Blood Reviews,2006,20:213-226..
  7. 7. SARNAK MJ, TIGHIOUART H, MANJUNATH G, et al.Anemia as a risk factor for cardiovascular disease in The Atherosclerosis Risk in Communities （ARIC） study[J].J Am Coll Cardiol,2002,40（1）:27-33..
  8. 8. 中華醫(yī)學會糖尿病學分會代謝綜合征研究協(xié)作組.中華醫(yī)學會糖尿病學分會關于代謝綜合征的建議[J].中華糖尿病雜志,2004,12（3）:156-161..
  9. 9. ALISSA EM, AHMED WH,ALAMA N, et al.Relationship between indices of iron status and coronary risk fators including diabetes and the metabolic syndrome in Saudi subjects without overt coronary disease[J].J Trace Elem Med Biol,2007, 21（4）:242-254.
  10. 10. VARI IS, BALKAU B, KETTANEH A, et al. Ferritin and transferrin are associated with metabolic syndrome abnormalities and their change over time in a general population: Data from an epidemilological Study on the Insulin Resistance syndrome （DESIR）[J]. Diabetes Care,2007,30（7）:1795-1801..
  11. 11. WILLIAMS M J, POULTON R, WILLIAMS S. Relationship of serum ferritin with cardiovascular risk factors and inflammation in young men and women[J]. Atherosclerosis,2002,165（1）:179-184..
  12. 12. KIM J A, CHOI Y S, HONG J I, et al. Association of metabolic syndrome with white blood cell subtype and red blood cells[J]. Endocr J,2006,53（1）:133-139.
  13. 13. MARDI T, TOKER S, MELAMED S, et al. Increased erythropoiesis and subclinical inflammation as part of the metabolic syndrome[J]. Diabetes Res Clin Prac,2005,69（3）:249-155..
  14. 14. CUNIETTI E, CHIARI M M, MONTI M, et al. Distortion of iron status indices by acute inflammation in older hospitalized patients[J]. Arch Gerontol Geriatr,2004,39（1）:35-42..
  15. 15. SHARP D S, CURB J D, SCHATZ I J, et al. Mean red cell volume as a correlate of blood pressure[J]. Circulation,1996,93（9）:1677-1684..