目的:探討孟魯司特鈉(順爾寧)對(duì)呼吸道合胞病毒(RSV)毛細(xì)支氣管炎患兒血清中半胱氨酰白三烯(CysLTs)的影響。方法:將60例4～18個(gè)月的RSV毛細(xì)支氣管炎患兒隨機(jī)分為順爾寧治療組(30例)和常規(guī)治療組(30例),常規(guī)治療組僅給予綜合治療,而順爾寧治療組在綜合治療的基礎(chǔ)上加用孟魯司特口服,用法為4mg每晚1次口服。于治療前和治療后檢測血清中CysLTs水平。結(jié)果:治療前,RSV毛細(xì)支氣管炎兩組CysLTs水平均明顯高于正常組(P lt;005),同時(shí)CysLTs水平較常規(guī)治療組顯著下降(P lt;005),常規(guī)治療組患兒血清CysLTs水平仍高于正常組(P lt;005)。結(jié)論:順爾寧可降低RSV毛細(xì)支氣管炎患兒血清中CysLTs水平,在RSV毛細(xì)支氣管炎的抗炎機(jī)制中起重要作用,推測RSV毛細(xì)支氣管炎患兒口服孟魯司特有可能達(dá)到早期干預(yù),從另一條途徑減少哮喘的發(fā)病。
引用本文： 李蘭,樊紅,胡怡萍,王智斌,蔣虹,陽倩,李敏,陳昌輝. 孟魯司特治療毛細(xì)支氣管炎前后患兒血清半胱氨酰白三烯的測定. 華西醫(yī)學(xué), 2009, 24(5): 1152-1153. doi: 復(fù)制
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- 2. WELLIVER R C. Therapy for bronchiolitis:Help wanted [J]. J Pediatr,1997,130(2):170.
- 3. PIEDIMONTE G, SIMOES E A. Respiratory syncytial virus and subsequent asthma[J]. Eur Respir J,2002,20(3):515517.
- 4. NGAMPHAIBOON J. Montelukast in general pedi atric practices [J]. J Med Assoc Thai,2005,88(4):348.
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