• 四川大學華西醫(yī)院老年科,四川成都 610041;

目的:研究大豆異黃酮對D半乳糖致衰老大鼠抗氧化能力的影響。方法:用D半乳糖注射Wistar雄性大鼠5個月,建立衰老模型。對致衰老模型組、大豆異黃酮組肝臟、心臟和前列腺丙二醛(MDA)含量、超氧化物歧化酶(SOD)、谷胱甘肽過氧化酶(GSHPx)活性進行測定及比較。結(jié)果:低、中、高不同劑量大豆異黃酮灌喂組與模型組大鼠相比,各臟器MDA含量(μmol/L)(心臟:695±093,562±112,435±112比802±111;肝臟:815±085,647±120,515±112比935±135;前列腺:715±092,558±115,423±125比833±124)均有降低,差異有統(tǒng)計學意義(P lt;005),而SOD酶活性(nmol/L)(心臟:4732±308,5518±428,6120±368比3225±370;肝臟:18121±506,19015±706,19720±570比17213±512;前列腺:4156±301,4607±421,5015±335比3374±305)和GSHPx酶活性(nmol/L)(心臟:905±096,1111±245,1313±146比713±151;肝臟:902±105,1150±223,1362±192比698±160;前列腺:435±085,613±102,747±155比312±106)有升高,差異同樣具有統(tǒng)計學意義(P lt;005);大豆異黃酮攝入量越高,MDA含量越低,而SOD、GSHPx酶活性越高。結(jié)論:攝入適量大豆異黃酮可有效增強大鼠機體抗氧化能力,從而延緩D半乳糖誘發(fā)的大鼠衰老。

引用本文： 張艷玲,楊中華,董碧蓉. 大豆異黃酮對衰老大鼠抗氧化功能的影響. 華西醫(yī)學, 2009, 24(5): 1183-1185. doi: 復制

1.
2.
3.
4.
5. WISEMAN H, O’Reilly J D, Adlercreutz H, et al. Isoflavone phytoestrogens consumed in decrease F2isoprostane concentrations and increase resistance of lowdensity lipoprotein to oxidation in humans[J]. Am J Clin Nutr,2000,72:395400.
6. 惠伯棣.類胡蘿卜素化學及生物化學[M].北京:中國輕工業(yè)出版社,2005:312327.
7. 裴凌鵬,金宗濂.葛根黃酮改善小鼠抗氧化功能的研究[J].營養(yǎng)學報,2004,26(6):505506.
8. DE ZWART L L, MEERMAN J H N, COMMANDEUR J N M, et al. Biomarkers of free radical damage: applications in experimental animals and in humans[J]. Free Radic Biol Med,1999,26(12):202226.
9. MILLER E, MALINOWSK K, GATECKA E, et al. Role of flavonoids as antioxidants in human organism[J]. Pol Merkur Lekarski,2008,24(144):556560.
10. WEI H C, CAI Q Y, RAHN R O. Inhibition of UV light and Fenton reactioninduced oxidative DNA damage by the soybean isoflavone genistein[J]. Carcinogenesis,1996,17(1): 7377.
11. WOOD C E, CLINE J M, ANTHONY M S, et al. Adrenocortical effects of oral estrogens and soy isoflavones in female monkeys[J]. J Clin Endocrinol Metab,2004,89(5):23192325.
12. Hong J L, Ho C Y, Kwong K, et al. Activation of pulmonary C fibres by adenosine in anaesthetized rats: role of adenosine A1 receptors[J]. J Physiol,1998,508(Pt 1):109118.
  1. 1.
  2. 2.
  3. 3.
  4. 4.
  5. 5. WISEMAN H, O’Reilly J D, Adlercreutz H, et al. Isoflavone phytoestrogens consumed in decrease F2isoprostane concentrations and increase resistance of lowdensity lipoprotein to oxidation in humans[J]. Am J Clin Nutr,2000,72:395400.
  6. 6. 惠伯棣.類胡蘿卜素化學及生物化學[M].北京:中國輕工業(yè)出版社,2005:312327.
  7. 7. 裴凌鵬,金宗濂.葛根黃酮改善小鼠抗氧化功能的研究[J].營養(yǎng)學報,2004,26(6):505506.
  8. 8. DE ZWART L L, MEERMAN J H N, COMMANDEUR J N M, et al. Biomarkers of free radical damage: applications in experimental animals and in humans[J]. Free Radic Biol Med,1999,26(12):202226.
  9. 9. MILLER E, MALINOWSK K, GATECKA E, et al. Role of flavonoids as antioxidants in human organism[J]. Pol Merkur Lekarski,2008,24(144):556560.
  10. 10. WEI H C, CAI Q Y, RAHN R O. Inhibition of UV light and Fenton reactioninduced oxidative DNA damage by the soybean isoflavone genistein[J]. Carcinogenesis,1996,17(1): 7377.
  11. 11. WOOD C E, CLINE J M, ANTHONY M S, et al. Adrenocortical effects of oral estrogens and soy isoflavones in female monkeys[J]. J Clin Endocrinol Metab,2004,89(5):23192325.
  12. 12. Hong J L, Ho C Y, Kwong K, et al. Activation of pulmonary C fibres by adenosine in anaesthetized rats: role of adenosine A1 receptors[J]. J Physiol,1998,508(Pt 1):109118.