• 四川大學(xué)華西第二醫(yī)院婦產(chǎn)科,四川成都 610041;

引用本文： 林琳,王平,尹如鐵,王丹青. 姜黃素抗腫瘤機(jī)制研究進(jìn)展. 華西醫(yī)學(xué), 2009, 24(5): 1320-1322. doi: 復(fù)制

1. 王箴.化工辭典.第4版[M].北京:化學(xué)工業(yè)出版社,2001:459.
2. KUTTAN R, BHANUMATHY P, NIRMALA K, et al. Potential anticancer activity of turmeric(Curcuma longa)[J]. Cancer Lett,1985,29(2):197.
3. ODOT J,ALBERT P,CARLIER A, et al. I(xiàn)n vitro and in vivo antitumoral effect of curcumin against melanoma cells[J]. Int J Cancer,2004,111(3):381-387.
4. CHAUHAN D P. Chemotherapeutic potential of curcumin for colorectal cancer[J]. Curr Pharm Des,2002,8(19):1695-1706.
5. CHEN Y S, HO C C, CHENY C K, et al. Curcumin inhibited the arylamines Nacetyltransferase activity, gene expression and DNA adduct formation in human lung cancer cells(A549)[J]. Toxicol In Vitro,2003,17(3):323-333.
6. BUSH J A, CHEUNG K J JR, LI G. Curcumin induces apoptosis in human melanoma cells through a Fas receptor/caspase8 pathway independent of p53[J]. Exp Cell Res,2001,271(2):305314.
7. 劉立民,孔祥波,常喜華,等.姜黃素對(duì)前列腺癌PC3M細(xì)胞生長(zhǎng)抑制和凋亡的影響[J].吉林大學(xué)學(xué)報(bào):醫(yī)學(xué)版,2007,33(2):283-285.
8. 鄭麗端,童強(qiáng)松,吳翠環(huán),等.姜黃素誘導(dǎo)卵巢癌細(xì)胞株A2780細(xì)胞周期阻滯和凋亡[J].華中科技大學(xué)學(xué)報(bào)(醫(yī)學(xué)版),2003,32(2):209-211.
9. 吳勇,陳元仲,許建華,等.姜黃素對(duì)人類Burkitt淋巴瘤抗癌作用的研究[J].中華腫瘤雜志,2002,24(4):348-351.
10. 田慧軍,王笛樂(lè).姜黃素誘導(dǎo)人結(jié)腸癌細(xì)胞株SW480凋亡及其bcl2表達(dá)相關(guān)性研究[J].腫瘤防治研究,2006,33(3):185-187.
11. RAY S, CHATTOPADHYAY N, MITRA A, et al. Curcumin exhibits antimetastatic properties by modulating integrin receptors, collagenase activity, and expression of Nm23 and Ecadherin[J]. Environ Pathol Toxicol Oncol,2003,22(1):49-58.
12. ROBINSON T P, EHLERS T, HUBBARD Ⅳ R B, et al. Design, synthesis, and biological evaluation of angiogenesis inhibitors: aromatic enone and dienone analogues of curcumin[J]. Bioorg Med Chem Lett,2003,13(1):115-117.
13. LIN Y G, KUNNUMAKKARA A B, NAIR A, et al. Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factorκB pathway[J]. Clin Cancer Res,2007,13(11):3423-3430.
14. LIN Y G, KUNNUMAKKARA A B, NAIR A, et al. Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factorκB pathway[J]. Clin Cancer Res,2007,13(11):3423-3430.
15. GURURAJ A E, BELAKAVADR M, VENKATESH D A, et al. Molecular mechanisms of antiangiogenic effect of curcumin[J]. Biochem Biophys Res Commun,2002,297(4):934-942.
16. GURURAJ A E, BELAKAVADR M, VENKATESH D A, et al. Molecular mechanisms of antiangiogenic effect of curcumin[J]. Biochem Biophys Res Commun,2002,297(4):934-942.
17. BANERJI A, CHAKRABARTI J, MITRA A, et al. Effect of curcumin on gelatinase A(MMP2) activity in B16F10 melanoma cells[J]. Cancer Lett,2004,211(2):235-242.
18. BANERJI A, CHAKRABARTI J, MITRA A, et al. Effect of curcumin on gelatinase A(MMP2) activity in B16F10 melanoma cells[J]. Cancer Lett,2004,211(2):235-242.
19. CHUN K S, KEUM Y S, HAN S S, et al. Curcumin inhibits phorbol esterinduced expression of cyclooxygenase2 in mouse skin through suppression of extracellular signalregulated kinase activity and NFκB activation[J]. Carcinogenesis,2003,24(9):15151524.
20. CHUN K S, KEUM Y S, HAN S S, et al. Curcumin inhibits phorbol esterinduced expression of cyclooxygenase2 in mouse skin through suppression of extracellular signalregulated kinase activity and NFκB activation[J]. Carcinogenesis,2003,24(9):1515-1524.
21. DICKINSON D A, ILES K E, ZHANG H, et al. Curcumin alters EpRE and AP1 binding complexes and elevates glutamatecysteine ligase gene expression[J]. FASEB J,2003,17(3):473475.
22. DICKINSON D A, ILES K E, ZHANG H, et al. Curcumin alters EpRE and AP1 binding complexes and elevates glutamatecysteine ligase gene expression[J]. FASEB J,2003,17(3):473-475.
23. PRUSTY B K, Das B C. Constitutive activation of transcription factor AP1 in cervical cancer and suppression of human papillomavirus(HPV) transcription and AP1 activity in HeLa cells by curcumin[J]. Int J Cancer,2005,113(6):951960.
24. PRUSTY B K, Das B C. Constitutive activation of transcription factor AP1 in cervical cancer and suppression of human papillomavirus(HPV) transcription and AP1 activity in HeLa cells by curcumin[J]. Int J Cancer,2005,113(6):951-960.
25. HOLY J. Curcumin inhibits cell motility and alters microfilament organization and function in prostate cancer cells[J]. Cell Moti Cytoskeleton,2004,58(4):253268.
26. HOLY J. Curcumin inhibits cell motility and alters microfilament organization and function in prostate cancer cells[J]. Cell Moti Cytoskeleton,2004,58(4):253-268.
27. ANUCHAPREEDA S, LEECHANACHAI P, SMITH M M, et al. Modulation of Pglycoprotein expression and function by curcumin in multidrugresistant human KB cells[J]. Biochem Pharmacol,2002,64(4):573-582.
28. ANUCHAPREEDA S, LEECHANACHAI P, SMITH M M, et al. Modulation of Pglycoprotein expression and function by curcumin in multidrugresistant human KB cells[J]. Biochem Pharmacol,2002,64(4):573-582.
29. 張慧珠,楊林,李小娜,等.姜黃素體外增敏抗腫瘤藥物作用[J].華西藥學(xué)雜志,2003,18(3):172-174.
30. 張慧珠,楊林,李小娜,等.姜黃素體外增敏抗腫瘤藥物作用[J].華西藥學(xué)雜志,2003,18(3):172-174.
31. 英煥春,張淑蘭,呂靖.姜黃素逆轉(zhuǎn)卵巢癌耐藥細(xì)胞株COC1/DDP耐藥性及機(jī)制的研究[J].現(xiàn)代腫瘤醫(yī)學(xué),2007,15(5):604-607.
32. 英煥春,張淑蘭,呂靖.姜黃素逆轉(zhuǎn)卵巢癌耐藥細(xì)胞株COC1/DDP耐藥性及機(jī)制的研究[J].現(xiàn)代腫瘤醫(yī)學(xué),2007,15(5):604-607.
33. CHAN M M, FONG D, SOPRANO K J, et al. Inhibition of growth and sensitization to cisplatinmediated killing of ovarian cancer cells polyphenolic chemopreventive agents[J]. J Cell Physiol,2003,194(1):63-70.
34. CHAN M M, FONG D, SOPRANO K J, et al. Inhibition of growth and sensitization to cisplatinmediated killing of ovarian cancer cells polyphenolic chemopreventive agents[J]. J Cell Physiol,2003,194(1):63-70.
35. PATEL B, SENGUPTA R, QAZI S, et al. Curcumin enhances the effects of 5fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF1R[J]. Int J Cancer,2008,122(2):267-273.
36. PATEL B, SENGUPTA R, QAZI S, et al. Curcumin enhances the effects of 5fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF1R[J]. Int J Cancer,2008,122(2):267-273.
37. 李昱辰,仲來(lái)福.姜黃素對(duì)順鉑所致大鼠腎毒性的防護(hù)作用及其可能機(jī)制[J].毒理學(xué)雜志,2005,19(3):270.
38. 李昱辰,仲來(lái)福.姜黃素對(duì)順鉑所致大鼠腎毒性的防護(hù)作用及其可能機(jī)制[J].毒理學(xué)雜志,2005,19(3):270.
39. 張英,王順蓉,陳蓉,等.姜黃素抗順鉑腎毒性作用及其機(jī)制研究[J].時(shí)珍國(guó)醫(yī)國(guó)藥,2007,18(7):1673-1675.
40. 張英,王順蓉,陳蓉,等.姜黃素抗順鉑腎毒性作用及其機(jī)制研究[J].時(shí)珍國(guó)醫(yī)國(guó)藥,2007,18(7):1673-1675.
41. 孫雅煊,王振華,李剛,等.姜黃素降低環(huán)磷酰胺致微核形成率[J].蘭州大學(xué)學(xué)報(bào)(醫(yī)學(xué)版),2006,32(3):27-30.
42. 孫雅煊,王振華,李剛,等.姜黃素降低環(huán)磷酰胺致微核形成率[J].蘭州大學(xué)學(xué)報(bào)(醫(yī)學(xué)版),2006,32(3):27-30.
43. WEIR N M, SELVENDIRAN K, KUTALA V K, et al. Curcumin induces G2/Marrest and apoptosis in cisplatinpesistant human ovarian cancer cells by modulating Akt and p38 MAPK[J]. Cancer Biol Ther,2007,6(2):178-184.
44. WEIR N M, SELVENDIRAN K, KUTALA V K, et al. Curcumin induces G2/Marrest and apoptosis in cisplatinpesistant human ovarian cancer cells by modulating Akt and p38 MAPK[J]. Cancer Biol Ther,2007,6(2):178-184.
45. BISWAS S K, MCCLURE D, JIMENEZ L A, et al. Curcumin induces glutathione biosynthesis and inhibits NFκB activation and interleukin8 release in alveolar epithelial cells: mechanism of free radical scavenging activity[J]. Antioxid Redox Signal,2005,7(12):32-41.
46. BISWAS S K, MCCLURE D, JIMENEZ L A, et al. Curcumin induces glutathione biosynthesis and inhibits NFκB activation and interleukin8 release in alveolar epithelial cells: mechanism of free radical scavenging activity[J]. Antioxid Redox Signal,2005,7(12):32-41.
47. SCOTT D W, LOO G. Curcumin induced GADD153 gene up regulation in human colon cancer cells[J]. Carcinogenesis,2004,25(11):2155-2164.
48. SCOTT D W, LOO G. Curcumin induced GADD153 gene up regulation in human colon cancer cells[J]. Carcinogenesis,2004,25(11):2155-2164.
  1. 1. 王箴.化工辭典.第4版[M].北京:化學(xué)工業(yè)出版社,2001:459.
  2. 2. KUTTAN R, BHANUMATHY P, NIRMALA K, et al. Potential anticancer activity of turmeric(Curcuma longa)[J]. Cancer Lett,1985,29(2):197.
  3. 3. ODOT J,ALBERT P,CARLIER A, et al. I(xiàn)n vitro and in vivo antitumoral effect of curcumin against melanoma cells[J]. Int J Cancer,2004,111(3):381-387.
  4. 4. CHAUHAN D P. Chemotherapeutic potential of curcumin for colorectal cancer[J]. Curr Pharm Des,2002,8(19):1695-1706.
  5. 5. CHEN Y S, HO C C, CHENY C K, et al. Curcumin inhibited the arylamines Nacetyltransferase activity, gene expression and DNA adduct formation in human lung cancer cells(A549)[J]. Toxicol In Vitro,2003,17(3):323-333.
  6. 6. BUSH J A, CHEUNG K J JR, LI G. Curcumin induces apoptosis in human melanoma cells through a Fas receptor/caspase8 pathway independent of p53[J]. Exp Cell Res,2001,271(2):305314.
  7. 7. 劉立民,孔祥波,常喜華,等.姜黃素對(duì)前列腺癌PC3M細(xì)胞生長(zhǎng)抑制和凋亡的影響[J].吉林大學(xué)學(xué)報(bào):醫(yī)學(xué)版,2007,33(2):283-285.
  8. 8. 鄭麗端,童強(qiáng)松,吳翠環(huán),等.姜黃素誘導(dǎo)卵巢癌細(xì)胞株A2780細(xì)胞周期阻滯和凋亡[J].華中科技大學(xué)學(xué)報(bào)(醫(yī)學(xué)版),2003,32(2):209-211.
  9. 9. 吳勇,陳元仲,許建華,等.姜黃素對(duì)人類Burkitt淋巴瘤抗癌作用的研究[J].中華腫瘤雜志,2002,24(4):348-351.
  10. 10. 田慧軍,王笛樂(lè).姜黃素誘導(dǎo)人結(jié)腸癌細(xì)胞株SW480凋亡及其bcl2表達(dá)相關(guān)性研究[J].腫瘤防治研究,2006,33(3):185-187.
  11. 11. RAY S, CHATTOPADHYAY N, MITRA A, et al. Curcumin exhibits antimetastatic properties by modulating integrin receptors, collagenase activity, and expression of Nm23 and Ecadherin[J]. Environ Pathol Toxicol Oncol,2003,22(1):49-58.
  12. 12. ROBINSON T P, EHLERS T, HUBBARD Ⅳ R B, et al. Design, synthesis, and biological evaluation of angiogenesis inhibitors: aromatic enone and dienone analogues of curcumin[J]. Bioorg Med Chem Lett,2003,13(1):115-117.
  13. 13. LIN Y G, KUNNUMAKKARA A B, NAIR A, et al. Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factorκB pathway[J]. Clin Cancer Res,2007,13(11):3423-3430.
  14. 14. LIN Y G, KUNNUMAKKARA A B, NAIR A, et al. Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factorκB pathway[J]. Clin Cancer Res,2007,13(11):3423-3430.
  15. 15. GURURAJ A E, BELAKAVADR M, VENKATESH D A, et al. Molecular mechanisms of antiangiogenic effect of curcumin[J]. Biochem Biophys Res Commun,2002,297(4):934-942.
  16. 16. GURURAJ A E, BELAKAVADR M, VENKATESH D A, et al. Molecular mechanisms of antiangiogenic effect of curcumin[J]. Biochem Biophys Res Commun,2002,297(4):934-942.
  17. 17. BANERJI A, CHAKRABARTI J, MITRA A, et al. Effect of curcumin on gelatinase A(MMP2) activity in B16F10 melanoma cells[J]. Cancer Lett,2004,211(2):235-242.
  18. 18. BANERJI A, CHAKRABARTI J, MITRA A, et al. Effect of curcumin on gelatinase A(MMP2) activity in B16F10 melanoma cells[J]. Cancer Lett,2004,211(2):235-242.
  19. 19. CHUN K S, KEUM Y S, HAN S S, et al. Curcumin inhibits phorbol esterinduced expression of cyclooxygenase2 in mouse skin through suppression of extracellular signalregulated kinase activity and NFκB activation[J]. Carcinogenesis,2003,24(9):15151524.
  20. 20. CHUN K S, KEUM Y S, HAN S S, et al. Curcumin inhibits phorbol esterinduced expression of cyclooxygenase2 in mouse skin through suppression of extracellular signalregulated kinase activity and NFκB activation[J]. Carcinogenesis,2003,24(9):1515-1524.
  21. 21. DICKINSON D A, ILES K E, ZHANG H, et al. Curcumin alters EpRE and AP1 binding complexes and elevates glutamatecysteine ligase gene expression[J]. FASEB J,2003,17(3):473475.
  22. 22. DICKINSON D A, ILES K E, ZHANG H, et al. Curcumin alters EpRE and AP1 binding complexes and elevates glutamatecysteine ligase gene expression[J]. FASEB J,2003,17(3):473-475.
  23. 23. PRUSTY B K, Das B C. Constitutive activation of transcription factor AP1 in cervical cancer and suppression of human papillomavirus(HPV) transcription and AP1 activity in HeLa cells by curcumin[J]. Int J Cancer,2005,113(6):951960.
  24. 24. PRUSTY B K, Das B C. Constitutive activation of transcription factor AP1 in cervical cancer and suppression of human papillomavirus(HPV) transcription and AP1 activity in HeLa cells by curcumin[J]. Int J Cancer,2005,113(6):951-960.
  25. 25. HOLY J. Curcumin inhibits cell motility and alters microfilament organization and function in prostate cancer cells[J]. Cell Moti Cytoskeleton,2004,58(4):253268.
  26. 26. HOLY J. Curcumin inhibits cell motility and alters microfilament organization and function in prostate cancer cells[J]. Cell Moti Cytoskeleton,2004,58(4):253-268.
  27. 27. ANUCHAPREEDA S, LEECHANACHAI P, SMITH M M, et al. Modulation of Pglycoprotein expression and function by curcumin in multidrugresistant human KB cells[J]. Biochem Pharmacol,2002,64(4):573-582.
  28. 28. ANUCHAPREEDA S, LEECHANACHAI P, SMITH M M, et al. Modulation of Pglycoprotein expression and function by curcumin in multidrugresistant human KB cells[J]. Biochem Pharmacol,2002,64(4):573-582.
  29. 29. 張慧珠,楊林,李小娜,等.姜黃素體外增敏抗腫瘤藥物作用[J].華西藥學(xué)雜志,2003,18(3):172-174.
  30. 30. 張慧珠,楊林,李小娜,等.姜黃素體外增敏抗腫瘤藥物作用[J].華西藥學(xué)雜志,2003,18(3):172-174.
  31. 31. 英煥春,張淑蘭,呂靖.姜黃素逆轉(zhuǎn)卵巢癌耐藥細(xì)胞株COC1/DDP耐藥性及機(jī)制的研究[J].現(xiàn)代腫瘤醫(yī)學(xué),2007,15(5):604-607.
  32. 32. 英煥春,張淑蘭,呂靖.姜黃素逆轉(zhuǎn)卵巢癌耐藥細(xì)胞株COC1/DDP耐藥性及機(jī)制的研究[J].現(xiàn)代腫瘤醫(yī)學(xué),2007,15(5):604-607.
  33. 33. CHAN M M, FONG D, SOPRANO K J, et al. Inhibition of growth and sensitization to cisplatinmediated killing of ovarian cancer cells polyphenolic chemopreventive agents[J]. J Cell Physiol,2003,194(1):63-70.
  34. 34. CHAN M M, FONG D, SOPRANO K J, et al. Inhibition of growth and sensitization to cisplatinmediated killing of ovarian cancer cells polyphenolic chemopreventive agents[J]. J Cell Physiol,2003,194(1):63-70.
  35. 35. PATEL B, SENGUPTA R, QAZI S, et al. Curcumin enhances the effects of 5fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF1R[J]. Int J Cancer,2008,122(2):267-273.
  36. 36. PATEL B, SENGUPTA R, QAZI S, et al. Curcumin enhances the effects of 5fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF1R[J]. Int J Cancer,2008,122(2):267-273.
  37. 37. 李昱辰,仲來(lái)福.姜黃素對(duì)順鉑所致大鼠腎毒性的防護(hù)作用及其可能機(jī)制[J].毒理學(xué)雜志,2005,19(3):270.
  38. 38. 李昱辰,仲來(lái)福.姜黃素對(duì)順鉑所致大鼠腎毒性的防護(hù)作用及其可能機(jī)制[J].毒理學(xué)雜志,2005,19(3):270.
  39. 39. 張英,王順蓉,陳蓉,等.姜黃素抗順鉑腎毒性作用及其機(jī)制研究[J].時(shí)珍國(guó)醫(yī)國(guó)藥,2007,18(7):1673-1675.
  40. 40. 張英,王順蓉,陳蓉,等.姜黃素抗順鉑腎毒性作用及其機(jī)制研究[J].時(shí)珍國(guó)醫(yī)國(guó)藥,2007,18(7):1673-1675.
  41. 41. 孫雅煊,王振華,李剛,等.姜黃素降低環(huán)磷酰胺致微核形成率[J].蘭州大學(xué)學(xué)報(bào)(醫(yī)學(xué)版),2006,32(3):27-30.
  42. 42. 孫雅煊,王振華,李剛,等.姜黃素降低環(huán)磷酰胺致微核形成率[J].蘭州大學(xué)學(xué)報(bào)(醫(yī)學(xué)版),2006,32(3):27-30.
  43. 43. WEIR N M, SELVENDIRAN K, KUTALA V K, et al. Curcumin induces G2/Marrest and apoptosis in cisplatinpesistant human ovarian cancer cells by modulating Akt and p38 MAPK[J]. Cancer Biol Ther,2007,6(2):178-184.
  44. 44. WEIR N M, SELVENDIRAN K, KUTALA V K, et al. Curcumin induces G2/Marrest and apoptosis in cisplatinpesistant human ovarian cancer cells by modulating Akt and p38 MAPK[J]. Cancer Biol Ther,2007,6(2):178-184.
  45. 45. BISWAS S K, MCCLURE D, JIMENEZ L A, et al. Curcumin induces glutathione biosynthesis and inhibits NFκB activation and interleukin8 release in alveolar epithelial cells: mechanism of free radical scavenging activity[J]. Antioxid Redox Signal,2005,7(12):32-41.
  46. 46. BISWAS S K, MCCLURE D, JIMENEZ L A, et al. Curcumin induces glutathione biosynthesis and inhibits NFκB activation and interleukin8 release in alveolar epithelial cells: mechanism of free radical scavenging activity[J]. Antioxid Redox Signal,2005,7(12):32-41.
  47. 47. SCOTT D W, LOO G. Curcumin induced GADD153 gene up regulation in human colon cancer cells[J]. Carcinogenesis,2004,25(11):2155-2164.
  48. 48. SCOTT D W, LOO G. Curcumin induced GADD153 gene up regulation in human colon cancer cells[J]. Carcinogenesis,2004,25(11):2155-2164.