• 1新疆醫(yī)科大學(xué),新疆烏魯木齊 830001; 2新疆維吾爾自治區(qū)人民醫(yī)院,新疆烏魯木齊 830002;

目的:觀察七氟醚靶控用于低流量吸入麻醉維持的臨床規(guī)律及血流動(dòng)力學(xué)變化,尋求靶控下的藥物量化指標(biāo)。方法:選擇60例20～60歲手術(shù)患者,隨機(jī)分2組每組30例:P組(丙泊酚)常規(guī)實(shí)施全憑靜脈TCI靶控麻醉;S組(七氟醚),實(shí)施低流量七氟醚靶控吸入麻醉(BIS值40)。分別記錄誘導(dǎo)前(T1),插管后5(T2)、15(T3)、30(T4)45(T5)、60(T6)、90(T7)、120(T8)min時(shí)的、MBP、HR、;Sev組患者加記各個(gè)時(shí)點(diǎn)的七氟醚IT、ET的MAC值。結(jié)果:T2點(diǎn)兩組均比T1 降低(P lt;0.05),S 組高于P組(P lt;0.05),兩組比較T3至T7無(wú)顯著性差異(P gt;0.05);S 組T3 至T7 各點(diǎn)ET值無(wú)統(tǒng)計(jì)學(xué)差異,ET%:2.46,約1.4 MAC。結(jié)論:(1)七氟醚誘導(dǎo)較靜脈麻醉誘導(dǎo)患者血流動(dòng)力學(xué)穩(wěn)定,(2)低流量七氟醚靶控吸入麻醉維持平穩(wěn),調(diào)控簡(jiǎn)便,效果良好。

引用本文： 蘇濤,王在義,伍湘伊,徐桂萍. 低流量七氟醚靶控吸入與丙泊酚TCI的臨床對(duì)比研究. 華西醫(yī)學(xué), 2009, 24(7): 1695-1698. doi: 復(fù)制

1. 莊心良,曾因明,陳伯鑾.現(xiàn)代麻醉學(xué)[M].3版.北京:人民衛(wèi)生出版社,2003:446-448.
2. VIITANEN H, ANNILA P, VIITANEN M, et al. Premeditation with midazolam delays recovery after ambulatory sevoflurane anesthesia in children[J].Anesth Analg,1999,8(91):75.
3. MALAN TPJ, DINARDO J A, ISNER R J, et al. Cardiovascular effects of servo fluraneeom Pared with those of isofiurane in volunteers[J]. Anesthesiology,1995,83:918-28.
4. MAPLESON W W. Effec to fageon MAC analysis[J].Br J Anaesth,1996,76:179-85.
5. EGER EL ZND, SAIDNLAN L J, BRANDSTATER B. Minimum alveolar anesthetic concentration:a standard of anesthetic potency[J].Anesthesiology,1965,26:756-63.
6. KEIJZER C, PEREZ R S, DE LANGE J J. Compound A and carbon monoxide production from sevoflurane and seven different types of carbon dioxide absorbent in a patient model[J]. Acta Anaesthesiol Scand, 2007, 51:31-37.
  1. 1. 莊心良,曾因明,陳伯鑾.現(xiàn)代麻醉學(xué)[M].3版.北京:人民衛(wèi)生出版社,2003:446-448.
  2. 2. VIITANEN H, ANNILA P, VIITANEN M, et al. Premeditation with midazolam delays recovery after ambulatory sevoflurane anesthesia in children[J].Anesth Analg,1999,8(91):75.
  3. 3. MALAN TPJ, DINARDO J A, ISNER R J, et al. Cardiovascular effects of servo fluraneeom Pared with those of isofiurane in volunteers[J]. Anesthesiology,1995,83:918-28.
  4. 4. MAPLESON W W. Effec to fageon MAC analysis[J].Br J Anaesth,1996,76:179-85.
  5. 5. EGER EL ZND, SAIDNLAN L J, BRANDSTATER B. Minimum alveolar anesthetic concentration:a standard of anesthetic potency[J].Anesthesiology,1965,26:756-63.
  6. 6. KEIJZER C, PEREZ R S, DE LANGE J J. Compound A and carbon monoxide production from sevoflurane and seven different types of carbon dioxide absorbent in a patient model[J]. Acta Anaesthesiol Scand, 2007, 51:31-37.