• 四川省成都市心血管病研究所、成都市第三人民醫(yī)院心內(nèi)科,四川成都 610031;

目的:觀察纈沙坦逆轉(zhuǎn)輕中度原發(fā)性高血壓左室肥厚的療效。方法:采用自身對(duì)照試驗(yàn), 116 例輕中度原發(fā)性高血壓伴左室肥厚的患者, 服用纈沙坦80～160mg/d, 共36 周, 隨訪患者血壓、超聲心動(dòng)圖及不良反應(yīng)。結(jié)果: 116例患者治療后血壓明顯下降(P lt;0.05), 左心室舒末內(nèi)徑(LVDd)、室間隔厚度(IVST) 、心室后壁厚度(PWT) 、左室重指數(shù)(LVMI) 均明顯減少 (P 均 lt;0.01),無明顯不良反應(yīng)。結(jié)論: 纈沙坦治療輕中度原發(fā)性高血壓療效確切, 有效逆轉(zhuǎn)左室肥厚。

引用本文： 吳鏡,蔡琳,王偉,唐炯,羅俊,燕純伯,鄧曉奇. 纈沙坦逆轉(zhuǎn)輕中度原發(fā)性高血壓左心室肥厚療效觀察. 華西醫(yī)學(xué), 2009, 24(7): 1818-1820. doi: 復(fù)制

1.
2. 英俊岐, 王歆月, 濮蓉暉, 等. 高血壓左室肥厚形成及其逆轉(zhuǎn)研究進(jìn)展[J]. 醫(yī)學(xué)綜述, 2003, 9 (12): 738-740..
3. 許智韜, 王瑋, 田青, 等. 高血壓患者左心室肥厚與QT離散度增大[J]. 中華心律失常雜志, 2000, 4: 276-277..
4. LEENEN FHH. Left ventricular hypertrophy in patients [J]. Am J Med, 1989, 86 (IB): 63-67..
5. 劉力生. 中國高血壓防治指南[M]. 北京: 人民衛(wèi)生出版社,2005: 14..
6. CIRCULATION. 2009,119(4):524-9..
7. MED PREGL.2008,61(7-8):369-374..
8. 丁國峰, 孫運(yùn)愛, 武金蓮, 等. 氨氯地平治療高血壓及逆轉(zhuǎn)左室肥厚作用的臨床研究[J]. 心血管康復(fù)醫(yī)學(xué)雜志, 2004, 13(2): 163-165..
9. BRAZ NOGUEIRA J. Regression of left ventricular hypertrophy in hypertensiondoes it reduce cardiovascular risk? [J]. Rev Port Cardiol, 2005, 24 (728): 1007-1013..
10. OKIN PM, DEVEREUX RB, JERN S, et al. Regression of electrocardiographic left ventricular hypertrophy during antihypertensive treatmentand the prediction of major cardiovascular events[ J ]. JAMA, 2004,292 (19): 2343-2349.
11. CONRADY AO, RUDOMANOV OG, ZAHAROV DV, et al. Prospective study of the changes in left ventricularmass and geometry patterns in hypertensive patients During 5 years of followup [ J ]. Circ J, 2005, 69(11): 1374-1379..
12. DEVEREUX RB. Therapeutic options in minimizing left ventricular hypertrophy [ J ]. Am Heart J, 2000,139: 9..
13. NIPPON RINSHO.2009,67(4):723-8..
14. 陳文彬,羅德成,主編. 臨床藥物治療學(xué)[M]. 北京:人民衛(wèi)生出版社,2004:107..
15. CALIFF RM, COHN JN, MINM M. Cardiac protection: Evolving role of angiotensin receptor blockers [ J ]. Am Heart J, 2000, 139: 15..
  1. 1.
  2. 2. 英俊岐, 王歆月, 濮蓉暉, 等. 高血壓左室肥厚形成及其逆轉(zhuǎn)研究進(jìn)展[J]. 醫(yī)學(xué)綜述, 2003, 9 (12): 738-740..
  3. 3. 許智韜, 王瑋, 田青, 等. 高血壓患者左心室肥厚與QT離散度增大[J]. 中華心律失常雜志, 2000, 4: 276-277..
  4. 4. LEENEN FHH. Left ventricular hypertrophy in patients [J]. Am J Med, 1989, 86 (IB): 63-67..
  5. 5. 劉力生. 中國高血壓防治指南[M]. 北京: 人民衛(wèi)生出版社,2005: 14..
  6. 6. CIRCULATION. 2009,119(4):524-9..
  7. 7. MED PREGL.2008,61(7-8):369-374..
  8. 8. 丁國峰, 孫運(yùn)愛, 武金蓮, 等. 氨氯地平治療高血壓及逆轉(zhuǎn)左室肥厚作用的臨床研究[J]. 心血管康復(fù)醫(yī)學(xué)雜志, 2004, 13(2): 163-165..
  9. 9. BRAZ NOGUEIRA J. Regression of left ventricular hypertrophy in hypertensiondoes it reduce cardiovascular risk? [J]. Rev Port Cardiol, 2005, 24 (728): 1007-1013..
  10. 10. OKIN PM, DEVEREUX RB, JERN S, et al. Regression of electrocardiographic left ventricular hypertrophy during antihypertensive treatmentand the prediction of major cardiovascular events[ J ]. JAMA, 2004,292 (19): 2343-2349.
  11. 11. CONRADY AO, RUDOMANOV OG, ZAHAROV DV, et al. Prospective study of the changes in left ventricularmass and geometry patterns in hypertensive patients During 5 years of followup [ J ]. Circ J, 2005, 69(11): 1374-1379..
  12. 12. DEVEREUX RB. Therapeutic options in minimizing left ventricular hypertrophy [ J ]. Am Heart J, 2000,139: 9..
  13. 13. NIPPON RINSHO.2009,67(4):723-8..
  14. 14. 陳文彬,羅德成,主編. 臨床藥物治療學(xué)[M]. 北京:人民衛(wèi)生出版社,2004:107..
  15. 15. CALIFF RM, COHN JN, MINM M. Cardiac protection: Evolving role of angiotensin receptor blockers [ J ]. Am Heart J, 2000, 139: 15..