• 廣州市中醫(yī)醫(yī)院心血管內(nèi)科,廣東廣州 10130;

目的:觀察氨氯地平片治療非杓型老年高血壓患者對(duì)血壓晝夜節(jié)律異常及對(duì)動(dòng)態(tài)動(dòng)脈硬化指數(shù)(AASI)的影響。方法:80例患者每日晨8時(shí)頓服氨氯地平5～10mg/d,服藥前及治療8周后行24h動(dòng)態(tài)血壓監(jiān)測(cè)。結(jié)果:80例完成治療的患者中,60例血壓晝夜節(jié)律異常逆轉(zhuǎn),同時(shí)改善AASI。而20例血壓晝夜節(jié)律無(wú)逆轉(zhuǎn),AASI與治療前比較無(wú)差異。結(jié)論:經(jīng)氨氯地平片治療后,75%的非杓型高血壓患者,可改善血壓晝夜節(jié)律異常及AASI。

引用本文： 何皓颋. 氨氯地平對(duì)老年高血壓患者血壓晝夜節(jié)律和動(dòng)態(tài)動(dòng)脈硬化指數(shù)異常的逆轉(zhuǎn)作用. 華西醫(yī)學(xué), 2009, 24(7): 1844-1846. doi: 復(fù)制

1. MAURIZIO G, ANTONIO P, ALFONSO A, et al . Impact of ambulatory blood pressure on left ventricular diastolic dysfuncfion in uncomplicated arterial systemic hypertension[J]. Am J Cardio,1996,77 (8):597-99..
2. LI Y, DOLAN E, WANG J G, et al . Ambulatory arterial stiffness index:determinant s and outcome[J]. Blood Press Monit,2006,11(2):107-10..
3. LI Y, WANG J G, DOLAN E, et al. Ambulatory arterial stiffness index derived from 24hour ambulatory blood pressure monitoring[J]. Hypertension, 2006,47(5): 359-64..
4. LEONCINI G, RATTO E, VIAZZI F,et al.Increased ambulatory arterial stiffness index is associated with target organ damage in primary hypertension[J].Hypertension,2006,48(3):397-03..
5. 韓全樂,高競(jìng)生,郝冰.動(dòng)態(tài)血壓監(jiān)測(cè)及其臨床應(yīng)用新進(jìn)展[J].中國(guó)煤炭工業(yè)醫(yī)學(xué)雜志,2008,11(1):125127..
6. O’BRIEN,SHERIDAN J, O’MALLET K. Dipper and non dipper [J ]. The Lancet,1988,11(8):397..
7. 龔蘭生,劉力生. 血壓晝夜變異及其臨床意義[J]. 中華心血管病雜志,1994,22(5):323-25..
8. 劉寶林,孟超,方寧遠(yuǎn)．老年高血壓患者血壓晝夜節(jié)律與左心室肥厚的相關(guān)性[J]．上海交通大學(xué)學(xué)報(bào)(醫(yī)學(xué)版),2008,28(5):509-11..
9. 劉衛(wèi),劉建國(guó),蘇定馮. 評(píng)價(jià)抗高血壓藥的新觀點(diǎn)和新方法[J].中國(guó)藥學(xué)雜志,1999,15(3):147..
10. YAN L I, JIGUANG WANG, EAMON D, et al. Ambulatory Arterial Stiffness Index Derived from 24Hour Ambulatory Blood Pressure Monitoring[J].Hypertension, 2006, 47(3):359-64..
11. MACWILLIAM J A, MELVIN G S. Systolic and Diastolic Blood Pressure Estimation, with Special Reference to the Auditory Methods [J].BMJ, 1914, 2: 693-97..
12. DOLAN E, THIJS L, LI Y, et al. Ambulatory aterial stiffness index as a predictor of cardiovascular mortality in the Dublin outcome study[J]. Hypertension,2006,47(2):365-70..
13. 張雪娟,徐傳金,唐曉燕,等.動(dòng)態(tài)血壓監(jiān)測(cè)評(píng)價(jià)苯磺酸氨氯地平和氯沙坦對(duì)老年單純收縮期高血壓的降壓療效[J].中國(guó)醫(yī)院藥學(xué)雜志,2008,28(3):137-39..
14. 李明珠,杜萱.動(dòng)態(tài)動(dòng)脈硬化指數(shù)與動(dòng)脈硬化研究進(jìn)展[J].中華老年心腦血管病雜志,2008,17(10):952-54..
  1. 1. MAURIZIO G, ANTONIO P, ALFONSO A, et al . Impact of ambulatory blood pressure on left ventricular diastolic dysfuncfion in uncomplicated arterial systemic hypertension[J]. Am J Cardio,1996,77 (8):597-99..
  2. 2. LI Y, DOLAN E, WANG J G, et al . Ambulatory arterial stiffness index:determinant s and outcome[J]. Blood Press Monit,2006,11(2):107-10..
  3. 3. LI Y, WANG J G, DOLAN E, et al. Ambulatory arterial stiffness index derived from 24hour ambulatory blood pressure monitoring[J]. Hypertension, 2006,47(5): 359-64..
  4. 4. LEONCINI G, RATTO E, VIAZZI F,et al.Increased ambulatory arterial stiffness index is associated with target organ damage in primary hypertension[J].Hypertension,2006,48(3):397-03..
  5. 5. 韓全樂,高競(jìng)生,郝冰.動(dòng)態(tài)血壓監(jiān)測(cè)及其臨床應(yīng)用新進(jìn)展[J].中國(guó)煤炭工業(yè)醫(yī)學(xué)雜志,2008,11(1):125127..
  6. 6. O’BRIEN,SHERIDAN J, O’MALLET K. Dipper and non dipper [J ]. The Lancet,1988,11(8):397..
  7. 7. 龔蘭生,劉力生. 血壓晝夜變異及其臨床意義[J]. 中華心血管病雜志,1994,22(5):323-25..
  8. 8. 劉寶林,孟超,方寧遠(yuǎn)．老年高血壓患者血壓晝夜節(jié)律與左心室肥厚的相關(guān)性[J]．上海交通大學(xué)學(xué)報(bào)(醫(yī)學(xué)版),2008,28(5):509-11..
  9. 9. 劉衛(wèi),劉建國(guó),蘇定馮. 評(píng)價(jià)抗高血壓藥的新觀點(diǎn)和新方法[J].中國(guó)藥學(xué)雜志,1999,15(3):147..
  10. 10. YAN L I, JIGUANG WANG, EAMON D, et al. Ambulatory Arterial Stiffness Index Derived from 24Hour Ambulatory Blood Pressure Monitoring[J].Hypertension, 2006, 47(3):359-64..
  11. 11. MACWILLIAM J A, MELVIN G S. Systolic and Diastolic Blood Pressure Estimation, with Special Reference to the Auditory Methods [J].BMJ, 1914, 2: 693-97..
  12. 12. DOLAN E, THIJS L, LI Y, et al. Ambulatory aterial stiffness index as a predictor of cardiovascular mortality in the Dublin outcome study[J]. Hypertension,2006,47(2):365-70..
  13. 13. 張雪娟,徐傳金,唐曉燕,等.動(dòng)態(tài)血壓監(jiān)測(cè)評(píng)價(jià)苯磺酸氨氯地平和氯沙坦對(duì)老年單純收縮期高血壓的降壓療效[J].中國(guó)醫(yī)院藥學(xué)雜志,2008,28(3):137-39..
  14. 14. 李明珠,杜萱.動(dòng)態(tài)動(dòng)脈硬化指數(shù)與動(dòng)脈硬化研究進(jìn)展[J].中華老年心腦血管病雜志,2008,17(10):952-54..