李靈 1 , 楊紅 2 , 李科 2 , 董丹丹 2
  • 1四川省醫(yī)科院.四川省人民醫(yī)院皮膚性病研究所,四川成都 610072;2四川省醫(yī)科院.四川省人民醫(yī)院病理科,四川成都 610072;

目的:觀察CyclinD1,P16在皮膚鱗狀細胞癌組織中的表達,探討CyclinD1,P16在皮膚鱗狀細胞癌發(fā)生發(fā)展中的作用。方法:用免疫組織化學技術檢測40例皮膚鱗癌石蠟包埋組織和10例正常皮膚組織的CyclinD1,P16表達。結果:CyclinD1在皮膚鱗癌組織中表達高于皮膚正常對照組,兩者差異有顯著統(tǒng)計學意義(P lt;0.01); P16在皮膚鱗癌組織中表達低于皮膚正常對照組,但兩者差異無顯著統(tǒng)計學意義(P gt;0.05);CyclinD1,P16在皮膚鱗癌中表達呈正相關性(r=0.782,P lt;0.01)。結論:CyclinD1在皮膚鱗狀細胞癌組織中陽性表達上調,P16在皮膚鱗狀細胞癌組織中陽性表達下調,CyclinD1,P16在皮膚鱗癌中表達呈正相關。

引用本文： 李靈,楊紅,李科,董丹丹. CyclinD1,P16,在皮膚鱗狀細胞癌中的表達和意義. 華西醫(yī)學, 2009, 24(8): 2042-2044. doi: 復制

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  2. 2. RESNITZKY D, GOSSEN M, BUJARD H,et al.l Acceleration of theG1/ S phase transition by expression of cyclinD1 and E with an inducible system[J]. MolCellBio, 1994, 14(3): 1669-1679.
  3. 3. 韋立蓓,濮德敏,尹伶.角化型外陰鱗狀細胞癌中p16和cyclin D1蛋白的表達[J].臨床與實驗病理學雜志, 2007,23(5):617-618.
  4. 4. LUKAS J, AAGAARD L, STRAUSS M, et al. Oncogenic aberrations ofp16INK4/CDKN2 and cyclin D1 cooperate to deregulate G1 control[J].Cancer Res, 1995,55:4818-4823.
  5. 5. OKAMI K, REED AL, CAIRNS P, et al. Cyclin D1 amplification is independent of p16 inactivation in head and neck squamous cell carcinoma[J]. Oncogene, 1999,18:3541-3545.
  6. 6. VICTORIA L, BROWN, CATHERINE A, et al. p16INK4a and p14ARF Tumor Suppressor Genes Are Commonly Inactivated in Cutaneous Squamous Cell Carcinoma[J]. Journal of Investigative Dermatology, 2004,122: 1284-1292.
  7. 7. 張繼剛.P16、CyclinD1在外陰鱗狀上皮增生和外陰鱗癌中的表達及意義[J]. 西北國防醫(yī)學雜志,2007,28(5):361-363.