• 四川大學(xué)華西醫(yī)院風(fēng)濕免疫科,四川成都 610041;

目的:探討類風(fēng)濕關(guān)節(jié)炎患者疾病活動(dòng)與血清中白介素-20(IL-20)水平的關(guān)系。方法:用酶標(biāo)記免疫吸附測(cè)定(enzyme-linked immunosorbent assay,ELISA)方法檢測(cè)60例類風(fēng)濕關(guān)節(jié)炎患者及30例正常對(duì)照者外周血血清中IL-20水平。分析IL-20水平與RA發(fā)病和類風(fēng)濕因子(rheumatoid factor,RF)、C反應(yīng)蛋白(C reactive protein,CRP)、血沉(erythrocyte sedimentation rate,ESR)及同期手X光片分期的相關(guān)性。結(jié)果:活動(dòng)期類風(fēng)濕關(guān)節(jié)炎患者外周血中IL-0水平明顯高于正常對(duì)照組(P lt;0.1)。類風(fēng)濕關(guān)節(jié)炎患者IL.0水平與其RF、CRP、血沉及同期手X光片分期無(wú)明顯相關(guān)性(P gt;0.)。結(jié)論:活動(dòng)期類風(fēng)濕關(guān)節(jié)炎患者外周血中IL-20平明顯高于正常對(duì)照組,但與RF、CRP、血沉及同期手X光片分期無(wú)明顯相關(guān)性。IL-0可能參與類風(fēng)濕關(guān)節(jié)炎的發(fā)病過(guò)程,提示需進(jìn)一步研究。

引用本文： 蒲曉英,楊南萍,李敏. 類風(fēng)濕關(guān)節(jié)炎患者血清白介素-20水平及影響因素研究. 華西醫(yī)學(xué), 2009, 24(8): 2054-2056. doi: 復(fù)制

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  1. 1. BECKER N, NIETERS A, RITTGEN W. Single nucleotide polymorphismdisease relationships: statistical issues for the performance of association studies[J]. Mutat Res,2003,525:11-18.
  2. 2. 呂誠(chéng),趙林華,肖誠(chéng),等.類風(fēng)濕關(guān)節(jié)炎患者外周血CD4+T淋巴細(xì)胞基因表達(dá)譜研究探討[J].中華風(fēng)濕病學(xué)雜志,2006,10(7):438-439.
  3. 3. NISHIMOTO N. Cytokine signal regulation and autoimmune disorders[J]. Autoimmunity,2005,38:359-367.
  4. 4. STEINER G S, MOLEN J S. Autoantibodies in rheumatoid arthritis and their clinical significance[J]. Arthritis Res,2002,4:S1-S5.
  5. 5. MIN S Y, HWANG S Y, PARK K S, et al. Induction of IL10producing CD4+ CD25+ T cells in animal model of collageninduced arthritis by oral administration of type Ⅱ collagen[J]. Arthritis Res Ther,2004,6(3):R213-R219.
  6. 6. BLUMBERG H, CONKLIN D, XU W F, et al. Interleukin 20: discovery, receptor identification, and role in epidermal function[J]. Cell,2001,104(1):9-19.
  7. 7. DUMOUTIER L, LEEMANS C, LEJEUNE D, et al. Cutting edge: STAT activation by IL19, IL-20 and mad27 through IL-20 receptor complexes of two types[J]. J Immunol,2001,167(7):3545-3549.
  8. 8. HSU Y H, LI H H, HSIEH M Y, et al. Function of Interleukin20 as a proinflammatory molecule in rheumatoid and experimental arthritis[J]. Arthritis Rheum,2006,54(9):2722-2733.
  9. 9. SCHETT G, TOHIDASTAKRAD M, SMOLEN J S, et al. Activation, differential localization, and regulation of the stressactivated protein kinases, extracellular signalregulated kinase, cJUNNterminal kinase, and p38 mitogen activated protein kinase, in synovial tissue and cells in rheumatoid arthritis[J]. Arthritis Rheum,2000,43:2501-2512.
  10. 10. 王妍敏,鄭捷.白介素10家族的新成員:白介素20[J].國(guó)外醫(yī)學(xué)·皮膚性病學(xué)分冊(cè),2003,29(2):117-119.