曾燕 1 , 江景 1 , 王玉 2
  • 1成都鐵路中心醫(yī)院婦產(chǎn)科,四川成都 610081; 2成都體育學(xué)院運(yùn)動醫(yī)學(xué)系,四川成都 610041;

目的:研究缺氧預(yù)處理對老年大鼠子宮及雙附件切除術(shù)后疲勞是否有改善作用,并通過對比觀察超氧化物歧化酶及丙二醛水平的變化,初步探討缺氧預(yù)處理的作用機(jī)制。方法:將老年大鼠分為空白對照組、對照組、缺氧預(yù)處理三組?？瞻讓φ战M為假手術(shù)組,對照組為子宮及雙附件切除術(shù)組, 缺氧預(yù)處理組為缺氧預(yù)處理加子宮及雙附件切除術(shù)組。對比觀察缺氧預(yù)處理對大鼠體力活動及血清超氧化物歧化酶和丙二醛水平的影響。結(jié)果:空白對照組、對照組、缺氧預(yù)處理三組大鼠懸尾不動時間分別為:(21±3)s,(83±10)s,(44±5)s,各組間比較P lt;0.05。三組SOD活性分別為:(131.23±5.31)U/L,(36.12±9.68)U/L,(73.01±9.82)U/L,各組間比較P lt;0.05。三組MDA水平分別為:(9.78±1.26)μmol/L,(29.87±3.13)μmol/L,(15.98±2.21)μmol/L,各組間比較P lt;0.05。結(jié)論:缺氧預(yù)處理可提高老年大鼠的抗氧化能力,對老年大鼠子宮及雙附件切除術(shù)后疲勞綜合征有明顯的改善作用。

引用本文： 曾燕,江景,王玉. 缺氧預(yù)處理對老年大鼠子宮及雙附件切除術(shù)后疲勞綜合征影響的研究. 華西醫(yī)學(xué), 2009, 24(8): 2095-2097. doi: 復(fù)制

1. RUBIN G J, HOTOPF M. Systematic review and metaanalysis of interventions for postoperative fatigue[J]. Br J Surg,2002,89(8):971-984.
2. MURRY C E, JENNING R B, REIMER K A. Preconditioning with ischmia: a delay of cell injury in ischemic myocardium[J]. Circulation,1986,74(5):1124-1136.
3. CHRISTENSEN T, KEHLET H. Postoperative fatigue[J].World J Surg,1993,17(2):220-225.
4. SALMON P, HALL G M. A theory of postoperative fatigue[J]. J R Soc Med,1997,90(12):661-664.
5. TSUTUI H. Oxidative stress in heart failure: the role of mitochondria[J]. Intern Med,2001,40 (12): 1177-1182.
6. CHANDRA M, SURENDRA K, KAPOOR R K, et al. Oxidant stress mechanisms in heart failure[J]. Boll Chim Farm,2000,139(3):149-152.
7. GLOSLI H, TRONSTAD K J, WERGEDAL H, et al. Human TNFα in transgenic mice induces differential changes in redox status and glutathioneregulating enzymes[J]. FASEB J,2002,16(11):1450-1452.
8. MALAPLATEARMAND C, GUEGUEN Y, BERTRAND P, et al. U373MG response to interleukin1βinduced oxidative stress[J]. Cell Biol Toxicol,2000,16(3):155-163.
9. IHNKEN K, WINKLERA, SCHLENSAK C, et al. Normoxic cardiopulmonary bypass reduces oxidative myocardial damage and nitric oxide during cardiac operations in the adult[J]. J Thorac Cardiovasc Surg,1998,116(2):327-334.
  1. 1. RUBIN G J, HOTOPF M. Systematic review and metaanalysis of interventions for postoperative fatigue[J]. Br J Surg,2002,89(8):971-984.
  2. 2. MURRY C E, JENNING R B, REIMER K A. Preconditioning with ischmia: a delay of cell injury in ischemic myocardium[J]. Circulation,1986,74(5):1124-1136.
  3. 3. CHRISTENSEN T, KEHLET H. Postoperative fatigue[J].World J Surg,1993,17(2):220-225.
  4. 4. SALMON P, HALL G M. A theory of postoperative fatigue[J]. J R Soc Med,1997,90(12):661-664.
  5. 5. TSUTUI H. Oxidative stress in heart failure: the role of mitochondria[J]. Intern Med,2001,40 (12): 1177-1182.
  6. 6. CHANDRA M, SURENDRA K, KAPOOR R K, et al. Oxidant stress mechanisms in heart failure[J]. Boll Chim Farm,2000,139(3):149-152.
  7. 7. GLOSLI H, TRONSTAD K J, WERGEDAL H, et al. Human TNFα in transgenic mice induces differential changes in redox status and glutathioneregulating enzymes[J]. FASEB J,2002,16(11):1450-1452.
  8. 8. MALAPLATEARMAND C, GUEGUEN Y, BERTRAND P, et al. U373MG response to interleukin1βinduced oxidative stress[J]. Cell Biol Toxicol,2000,16(3):155-163.
  9. 9. IHNKEN K, WINKLERA, SCHLENSAK C, et al. Normoxic cardiopulmonary bypass reduces oxidative myocardial damage and nitric oxide during cardiac operations in the adult[J]. J Thorac Cardiovasc Surg,1998,116(2):327-334.