• 四川省人民醫(yī)院草堂病區(qū),四川 成都 610041;

目的:觀察用白眉蛇毒血凝酶(邦亭)治療上消化道出血的療效。方法 上消化道出血患者90例,隨機分為治療組和對照組,所有病例均給予擴容及調整水電解質紊亂,靜滴奧美拉唑42.6mg,每日1次;靜滴卡絡磺鈉60mg,每日1次,重度貧血者予輸血。治療組再應用邦亭4 KU加生理鹽水20mL口服,每日2次,對照組用去甲腎上腺素8mg加生理鹽水90mL,每日分3次口服。結果 治療組總有效率93.75%,對照組總有效率8095%,兩組臨床療效差異有統(tǒng)計學意義(P lt;0.05)結論:白眉蛇毒血凝酶是一種有效的、安全的治療上消化道出血的藥物,在臨床止血治療中值得推廣應用。

引用本文： 曾明曦,康長明,曾凡蘭,徐麗瓊. 探討白眉蛇毒血凝酶治療上消化道出血的療效. 華西醫(yī)學, 2009, 24(9): 2340-2341. doi: 復制

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  2. 2. 蕭樹東,江紹基.胃腸病學(第一版)[M].上海:上海科學技術出版社,2001:188.
  3. 3. JONES S C, ARON ATR. Bleeding peptic ulcer endoscopic and pharmacological management[J]. postgard Med J,1991,67(4):606-608.
  4. 4. 崔紅,胡珉.邦亭與洛賽克聯(lián)用治療上消化道出血的療效觀察[J]. 醫(yī)學理論與實踐雜志,2006,(10): 1173-1174.
  5. 5. 方麗平,王克賢.凝血酶治療上消化道出血60例療效觀察[J].中國綜合臨床,1999,15(3):216.
  6. 6. SCHON I R. The use of snake venomderived compounds for new functional diagnostic test kits in the field of haemostasis[J]. Pathophysiol Haemost Thromb, 2005, 34 (4-5): 234 -240.
  7. 7. YOU W K, CHO I W S, KOH Y S, et al. Functional characterization of recombinant batroxobin, a snake venom thrombinlike enzyme, expressed from Pichia pastoris[J]. FEBS Lett,2004,571(1-3):67-73.
  8. 8. CA STRO H C,Z NGAL I R B,ALBUQU ERQU M G, et al. Snake venom thrombinlike enzymes: from reptilase to now[J]. Cell Mol Life Sci,2004,61(7-8):843-856.