目的:探討米索前列醇片在初次早早孕(≤42天)人工流產(chǎn)術(shù)前應(yīng)用的可行性、有效性及安全性。方法:將300例初次妊娠,孕周≤6周,擬行人工流產(chǎn)的婦女隨機分為口服米索組100例(A組)、陰道放置米索組100例(B組)、未使用米索對照組(C組)。A組術(shù)前2h口服米索前列醇片400 μg,B組術(shù)前2h陰道放置米索前列醇片400 μg。觀察并比較術(shù)前用藥的兩組不良反應(yīng)發(fā)生率、宮頸擴張效果、術(shù)中出血量、手術(shù)時間及術(shù)后宮頸粘連發(fā)生情況。結(jié)果:B組不良反應(yīng)發(fā)生率低于A組,差異有統(tǒng)計學(xué)意義(P lt;0.01);A、B兩組間術(shù)中宮頸擴張效果、術(shù)中出血量、手術(shù)時間及術(shù)后宮頸粘連發(fā)生率差異均無統(tǒng)計學(xué)意義(P gt;0.05),但與C組比較差異有統(tǒng)計學(xué)意義。結(jié)論:米索前列醇片口服和陰道放藥都可作為初次早早孕人工流產(chǎn)術(shù)前的給藥方法。更推薦不良反應(yīng)較小的陰道放藥。
引用本文： 王曉銀,劉敬濤,徐洲. 米索前列醇在早早孕人工流產(chǎn)術(shù)前的應(yīng)用. 華西醫(yī)學(xué), 2009, 24(9): 2405-2407. doi: 復(fù)制
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