• 四川省樂(lè)山市五通橋區(qū)人民醫(yī)院外二科,四川五通橋 614800;

目的:探討益生菌聯(lián)合營(yíng)養(yǎng)支持對(duì)胃腸外科術(shù)后患者腸功能和腸道菌群的影響。方法:36例胃腸道中等以上手術(shù)的患者,隨機(jī)分為研究組和對(duì)照組,每組18例。兩組術(shù)后均接受等氮等能量的營(yíng)養(yǎng)支持,研究組患者于術(shù)后第3天開(kāi)始每天加用益生菌制劑(6.6 × 10.7 colony forming units),共7天。監(jiān)測(cè)治療期間患者的胃腸道癥狀、生命體征、腹瀉情況和菌群比例等。結(jié)果:兩組患者術(shù)后腹痛、腹脹、腸鳴音異常等胃腸道癥狀均無(wú)顯著差異 (P gt;0.05),兩組患者在術(shù)后第8和9天的腹瀉比例和腹瀉評(píng)分差異有顯著性意義(P lt;0.05)。治療結(jié)束后,研究組患者腸道雙歧桿菌和乳酸桿菌計(jì)數(shù)均較對(duì)照組高,兩組間差異有顯著性意義(P lt;0.05)。 結(jié)論:在胃腸外科術(shù)后患者中應(yīng)用益生菌可改善胃腸道癥狀、減輕腹瀉程度和糾正腸道菌群失調(diào)。

引用本文： 李樹(shù)清,吳登貴. 益生菌在胃腸外科術(shù)后患者中的應(yīng)用. 華西醫(yī)學(xué), 2009, 24(10): 2538-2539. doi: 復(fù)制

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  2. 2. JAIN P K, MCNAUGHT C E, ANDERSON A D, et al. Influence of synbiotic containing Lactobacillus acidophilus La5, Bifidobacterium lactis Bb 12, Streptococcus thermophilus, Lactobacillus bulgaricus and oligofructose on gut barrier function and sepsis in critically ill patients: a randomised controlled trial[J]. Clin Nutr, 2004, 23:467-475.
  3. 3. HART G K, DOBB G J. Effect of a fecal bulking agent on diarrhea during enteral feeding in the critically ill [J]. JPEN, 1988, 12 (5): 465-468.
  4. 4. LILLY D M, STILLWELL R H. Probiotics: growthpromoting factors produced by microorganisms[J]. Science, 1965, 147:747-748.
  5. 5. LAUDANNO O M, CESOLARI J A, GODOY A, et al. Bioflora probiotic in immunomodulation and prophylaxis of intestinal bacterial translocation in rats[J]. Dig Dis Sci, 2008, 53:2667-2670.
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