摘要:目的: 探討PCNA,VEGF在胃癌組織中的表達關(guān)系及其意義。 方法 :免疫組織化學法檢測正常胃和胃癌組織中PCNA和VEGF的表達,并分析其與胃癌臨床病理特征的相關(guān)性。 結(jié)果 :胃癌組織中PCNA、VEGF的陽性表達率分別為850%、683%,二者在正常胃組織中均為隱性表達。PCNA的表達與腫瘤分期、淋巴結(jié)轉(zhuǎn)移有關(guān)(〖WTBX〗P lt;005),而與年齡、性別、腫瘤大小、組織分化程度無關(guān)(〖WTBX〗P gt;005);PCNA的表達與腫瘤分期、淋巴結(jié)轉(zhuǎn)移有關(guān)(〖WTBX〗P lt;005),而與年齡、性別、腫瘤大小、組織分化程度無關(guān)(〖WTBX〗P gt;005)。PCNA和VEGF在胃癌中的表達呈正相關(guān)。 結(jié)論 :PCNA和VEGF在胃癌組織中的高表達促進了胃癌的發(fā)生發(fā)展。
Abstract: Objective: To study the significance and relationship of expression of proliferating cell nuclear antigen(PCNA) and vascular endothelial growth factor (VEGF) in gastric cancer. Methods : The expression of VEGF and PCNA in normal gastric tissues and gastric cancer tissues were detected by immunohistochemistry (SP),and clinic pathological correlation with gastric cancer was analyzed. Results : The positive exression rates of PCNA and VEGF in gastric cancer were 850%、683%, respectively, while negative expression was shown in normal gastric tissues. It was found that the expressions of PCNA and VEGF were both in significant relation to TNM stages and lymph node metastasis (P lt;005), but in no relation to age, gender, diameter of tumor and tumor cell differentiation (P gt;005). The expressions of PCNA and VEGF were positively correlated with each other. Conclusion : It was indicated that the highlevel expressions of PCNA and VEGF might corporately accelerate the progression of gastric cancer.
引用本文： 周祥榮,李忠音,楊小東,杜志強. CNA和VEGF在胃癌組織中表達的關(guān)系及意義. 華西醫(yī)學, 2009, 24(10): 2585-. doi: 復(fù)制
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