摘要:目的: 分析特非那定所致不良反應(yīng)的臨床特征、相關(guān)因素,為臨床藥物治療中藥品不良反應(yīng)的防治提供參考依據(jù)。 方法 :檢索1986～2008年國內(nèi)文獻(xiàn)源特非那定的不良反應(yīng)資料,并加以分析研究。 結(jié)果 :34例不良反應(yīng)報(bào)告中女性明顯多于男性;不良反應(yīng)以心血管系統(tǒng)損害最多(23例,占6766%),其次為皮膚及附件損害(5例,1470%);不良反應(yīng)預(yù)后較好。 結(jié)論 :患者的性別、體質(zhì)、合并用藥等因素能影響不良反應(yīng)的發(fā)生,對(duì)于引起心律失常不良反應(yīng)臨床應(yīng)提高警惕,減少不良反應(yīng)的發(fā)生。
Abstract: Objective: To analyze the clinical features、correlation factors of ADRs caused by Terfenadine drugs and provide beneficial references for preventing and curing the ADRs. Methods :To collect and analyze the cases of ADRs caused by Terfenadine from medical journals of 19862008 Results :Women were more than men in 34 ADRs;cardiovascular system lesions accounted for 6766%,skin and its appendix lesions accounted for 1470%;ADRs prognosis well. Conclusion :The occurrence of ADRs caused by Terfenadine due to many factors such as sex、age and combination drug,ect. The ADRs caused by second generation antihistamine drugs must be reconstred.

引用本文： 陳加容,趙洪鑒. 特非那定不良反應(yīng)的回顧性分析. 華西醫(yī)學(xué), 2009, 24(10): 2644-. doi: 復(fù)制