摘要:目的:探討PTTG的表達(dá)在非小細(xì)胞肺癌發(fā)生、發(fā)展中的作用及其與CMYC蛋白表達(dá)的關(guān)系。方法:應(yīng)用免疫組化SP法檢測(cè)PTTG、CMYC二種蛋白在44例非小細(xì)胞肺癌、20例肺良性病變組織和12例正常支氣管粘膜上皮組織中的表達(dá)。結(jié)果:PTTG和CMYC蛋白在非小細(xì)胞肺癌組織中的表達(dá)明顯高于肺良性病變組及癌旁組織,在TNM分期、淋巴結(jié)轉(zhuǎn)移組間差別有統(tǒng)計(jì)學(xué)意義。非小細(xì)胞肺癌組織中PTTG與CMYC表達(dá)呈顯著正相關(guān)。結(jié)論:提示PTTG和CMYC可能參與了非小細(xì)胞肺癌的發(fā)生和發(fā)展,可作為反映其生物學(xué)行為的指標(biāo)。
Abstract: Objective: To investigate the expression of PTTG and its relationship with expressions of CMYC protein in human nonsmall cell lung cancer (NSCLC).Methods: Immunohistochemical methods were applied to detect the expression of PTTG,CMYCproteins in 44 surgical specimens from NSCLC patients,20 pneumonic benign lesion and 19 normal bronchial epithelium. Results:There were high erexpressions of PTTG,CMYC in NSCLC tissues than inadjacent tissues and benign lesions.There were statistical relationships between their expressions and TNM stage,lymphnode metastasis.The expression of PTTG was positively correlated with CMYC. Conclusion: Overexpression of PTTG,CMYC may be related to human NSCLC,PTTG and CMYC play a cooperative role inthe process of NSCLC,all of them may be used as important indices for biologic behavior of NSCLC.

引用本文： 任丹,王先麗. PTTG、CMYC基因過表達(dá)與非小細(xì)胞肺癌發(fā)生、發(fā)展的關(guān)系及其臨床意義. 華西醫(yī)學(xué), 2009, 24(11): 2863-2864. doi: 復(fù)制

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