摘要:目的:調(diào)查格列本脲的10年來不良反應(yīng)情況為臨床上合理使用格列本脲提供參考。方法:檢索近10年(1999~2009)維普中文科技期刊數(shù)據(jù)庫報道的格列本脲的不良反應(yīng)文獻(xiàn),進行統(tǒng)計、分析。結(jié)果:格列本脲不良反應(yīng)表現(xiàn)較多,機制復(fù)雜,最常見的是低血糖,其次是肝功能損傷。結(jié)論:臨床上應(yīng)該重視格列本脲的不良反應(yīng)情況,針對不同病人合理用藥。
Abstract: Objective: To investigate the adverse reaction of glibenclamide in resent ten years so as to promote rational clinical glibenclamide Use. Methods: The adverse reaction reports in the vipdatabase (19992009) were summarized and investigated. Results:There exist complicated mechanism and lots of clinical symptoms of the adverse reaction of glibenclamide. The most common adverse reaction of glibenclamide is glycopenia. Conclusion: Great attention should be paid to adverse reactions of glibenclamide for rational drug use. Glibenclamide should be used according to physiological and pathological situation of patients.

引用本文： 鄒榆紅,王國俊,姚欣宇. 格列本脲的不良反應(yīng)文獻(xiàn)分析. 華西醫(yī)學(xué), 2009, 24(11): 2974-2976. doi: 復(fù)制