• 新疆醫(yī)科大學(xué)附屬腫瘤醫(yī)院胃腸外科(新疆烏魯木齊 830011);

目的  探討直腸癌術(shù)后局部復(fù)發(fā)再次手術(shù)的臨床療效及影響療效的相關(guān)因素。
方法  回顧性分析2003年1月至2011年1月期間我科收治的直腸癌術(shù)后局部復(fù)發(fā)再次手術(shù)患者56例的臨床病理及部分隨訪資料,
采用χ2檢驗(yàn)分析術(shù)后不同復(fù)發(fā)時(shí)間和首次不同手術(shù)方式的再次手術(shù)完整切除率,利用log-rank方法對2種再次手術(shù)方式(Dixon和Miles手術(shù))進(jìn)行生存分析。
結(jié)果  ①直腸癌術(shù)后局部復(fù)發(fā)再次手術(shù)術(shù)中出血量、手術(shù)時(shí)間均明顯多于首次手術(shù),差異均有統(tǒng)計(jì)學(xué)意義(P<0.05)。②直腸癌根治術(shù)后5年以后局部復(fù)發(fā)者的完整切除率明顯高于直腸癌根治術(shù)后2年以內(nèi)局部復(fù)發(fā)者,差異有統(tǒng)計(jì)學(xué)意義(P<0.01)。③直腸癌首次術(shù)式為Dixon術(shù)者的局部復(fù)發(fā)病灶的完整切除率明顯高于首次術(shù)式為Miles術(shù)者,差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。④直腸癌術(shù)后局部復(fù)發(fā)患者再次手術(shù)為Dixon術(shù)者的中位生存時(shí)間、2年存活率及5年存活率均明顯長于或高于再次手術(shù)為Miles術(shù)者,差異均有統(tǒng)計(jì)學(xué)意義(P<0.05)。
結(jié)論  直腸癌首次手術(shù)方式不同及術(shù)后復(fù)發(fā)時(shí)間不同,可影響術(shù)后局部復(fù)發(fā)病灶再次完整切除的幾率,再次手術(shù)可作為直腸癌局部復(fù)發(fā)一種有效可行的治療方式。

引用本文: 王海江,趙澤亮,孫振強(qiáng),劉林. 直腸癌局部復(fù)發(fā)的再次手術(shù)56例分析. 中國普外基礎(chǔ)與臨床雜志, 2013, 20(11): 1224-1227. doi: 復(fù)制

1. 陳萬青, 張思維, 鄭榮壽, 等. 中國腫瘤登記地區(qū)2007年腫瘤發(fā)病和死亡分析[J]. 中國腫瘤, 2011, 20(3):162-169.
2. 巫佳明, 劉桂, 鐘其生. 直腸癌術(shù)后復(fù)發(fā)再手術(shù)治療的臨床分析[J]. 中國腫瘤臨床與康復(fù), 2005, 12(4):364-365.
3. 喬唐, 柏斗勝, 徐永建. 直腸癌Dixon術(shù)后局部復(fù)發(fā)原因及防治探討[J]. 實(shí)用臨床醫(yī)藥雜志, 2004, 8(2):79-80.
4. Baek SJ, Kim SH, Kwak JM, et al. Selective use of preoperative chemoradiotherapy for T3 rectal cancer can be justified:analysis of local recurrence[J]. World J Surg, 2013, 37(1):220-226.
5. Arredondo J, Baixauli J, Beorlegui C, et al. Prognosis factors for recurrence in patients with locally advanced rectal cancer preoperatively treated with chemoradiotherapy and adjuvant chemotherapy[J]. Dis Colon Rectum, 2013, 56(4):416-421.
6. Heald RJ, Smedh RK, Kald A, et al. Abdominoperineal excision of the rectum endangered operation[J]. Dis Colon Rectum, 1997, 40(7):747-751.
7. 韓加剛, 李志霞. 直腸癌的術(shù)前短期放射治療[J]. 國外醫(yī)學(xué):外科學(xué)分冊, 2004, 31(3):164-167.
8. Akiyoshi T, Watanabe T, Ueno M. Is lateral pelvic lymph node dissection no longer necessary for low rectal cancer after neoadjuvant therapy and TME to reduce local recurrence?[J]. J Gastrointest Surg, 2012, 16(12):2341-2342.
9. Guillem JG, Paty PB, Cohen AM. Surgical treatment of colorectalcancer[J]. CA Cancer J Clin, 1997, 47(2):113-128.
10. Law WL, Chu KW. Resection of local recurrence of rectal cancer:results[J]. World J Surg, 2000, 24(4):486-490.
11. Fuyi Z, Bo Y, Zhengjia L, et al. Long term observation of 367 cases of radical excision with anus preservation by casing anastomosis in low-rectal cancers[J]. Hepatogastroenterology, 2013, 60(124):738-740.
12. 毛捷鴻, 李小沛. 直腸癌術(shù)后局部復(fù)發(fā)的再手術(shù)治療(附25例報(bào)告)[J]. 中國普通外科雜志, 2001, 10(3):237-240.
13. Melton GB, Paty PB, Boland PJ, et al. Sacral resection for recu-rrent rectal cancer:analysis of morbidity and treatment results[J]. Dis Colon Rectum, 2006, 49(8):1099-1107.
14. Arredondo J, Miccini M, Borghese O, et al. Anastomotic leakageand septic complications:impact on local recurrence in surgery of low rectal cancer[J]. Ann Ital Chir, 2011, 82(2):117-123.
15. 萬德森. 低位直腸癌保肛手術(shù)后局部復(fù)發(fā)的對策[J]. 中華胃腸外科雜志, 2010, 13(8):557-561.
16. Park JK, Kim YW, Hur H, et al. Prognostic factors affectingoncologic outcomes in patients with locally recurrent rectal cancer:impact of patterns of pelvic recurrence on curative resection[J]. Langenbecks Arch Surg, 2009, 394(1):71-77.
17. Rudmik LR, Buie WD, Heine JA. Reoperation for intraluminal rectal cancer recurrence[J]. Dis Colon Rectum, 2005, 48(9):1752-1754.
18. 李保衛(wèi), 申連東, 任宏. 直腸癌術(shù)后局部復(fù)發(fā)再手術(shù)50例分析[J]. 陜西醫(yī)學(xué)雜志, 2010, 39(10):1424.
19. Henry LR, Sigurdson E, Ross E, et al. Hydronephrosis does not preclude curative resection of pelvic recurrences after colorectal surgery[J]. Ann Surg Oncol, 2005, 12(10):786-792.
20. 傅傳剛, 高顯華. 局部復(fù)發(fā)直腸癌再手術(shù)適應(yīng)證及手術(shù)方式的選擇[J]. 中國實(shí)用外科雜志, 2011, 31(4):287-289.
21. Mirnezami AH, Sagar PM. Surgery for recurrent rectal cancer:technical notes and management of complications[J]. Tech Coloproctol, 2010, 14(3):209-216.
22. Garcia-Aguilar J, Cromwell JW, Marra C, et al. Treatment of locally recurrent rectal cancer[J]. Dis Colon Rectum, 2001, 44(12):1743-1748.
  1. 1. 陳萬青, 張思維, 鄭榮壽, 等. 中國腫瘤登記地區(qū)2007年腫瘤發(fā)病和死亡分析[J]. 中國腫瘤, 2011, 20(3):162-169.
  2. 2. 巫佳明, 劉桂, 鐘其生. 直腸癌術(shù)后復(fù)發(fā)再手術(shù)治療的臨床分析[J]. 中國腫瘤臨床與康復(fù), 2005, 12(4):364-365.
  3. 3. 喬唐, 柏斗勝, 徐永建. 直腸癌Dixon術(shù)后局部復(fù)發(fā)原因及防治探討[J]. 實(shí)用臨床醫(yī)藥雜志, 2004, 8(2):79-80.
  4. 4. Baek SJ, Kim SH, Kwak JM, et al. Selective use of preoperative chemoradiotherapy for T3 rectal cancer can be justified:analysis of local recurrence[J]. World J Surg, 2013, 37(1):220-226.
  5. 5. Arredondo J, Baixauli J, Beorlegui C, et al. Prognosis factors for recurrence in patients with locally advanced rectal cancer preoperatively treated with chemoradiotherapy and adjuvant chemotherapy[J]. Dis Colon Rectum, 2013, 56(4):416-421.
  6. 6. Heald RJ, Smedh RK, Kald A, et al. Abdominoperineal excision of the rectum endangered operation[J]. Dis Colon Rectum, 1997, 40(7):747-751.
  7. 7. 韓加剛, 李志霞. 直腸癌的術(shù)前短期放射治療[J]. 國外醫(yī)學(xué):外科學(xué)分冊, 2004, 31(3):164-167.
  8. 8. Akiyoshi T, Watanabe T, Ueno M. Is lateral pelvic lymph node dissection no longer necessary for low rectal cancer after neoadjuvant therapy and TME to reduce local recurrence?[J]. J Gastrointest Surg, 2012, 16(12):2341-2342.
  9. 9. Guillem JG, Paty PB, Cohen AM. Surgical treatment of colorectalcancer[J]. CA Cancer J Clin, 1997, 47(2):113-128.
  10. 10. Law WL, Chu KW. Resection of local recurrence of rectal cancer:results[J]. World J Surg, 2000, 24(4):486-490.
  11. 11. Fuyi Z, Bo Y, Zhengjia L, et al. Long term observation of 367 cases of radical excision with anus preservation by casing anastomosis in low-rectal cancers[J]. Hepatogastroenterology, 2013, 60(124):738-740.
  12. 12. 毛捷鴻, 李小沛. 直腸癌術(shù)后局部復(fù)發(fā)的再手術(shù)治療(附25例報(bào)告)[J]. 中國普通外科雜志, 2001, 10(3):237-240.
  13. 13. Melton GB, Paty PB, Boland PJ, et al. Sacral resection for recu-rrent rectal cancer:analysis of morbidity and treatment results[J]. Dis Colon Rectum, 2006, 49(8):1099-1107.
  14. 14. Arredondo J, Miccini M, Borghese O, et al. Anastomotic leakageand septic complications:impact on local recurrence in surgery of low rectal cancer[J]. Ann Ital Chir, 2011, 82(2):117-123.
  15. 15. 萬德森. 低位直腸癌保肛手術(shù)后局部復(fù)發(fā)的對策[J]. 中華胃腸外科雜志, 2010, 13(8):557-561.
  16. 16. Park JK, Kim YW, Hur H, et al. Prognostic factors affectingoncologic outcomes in patients with locally recurrent rectal cancer:impact of patterns of pelvic recurrence on curative resection[J]. Langenbecks Arch Surg, 2009, 394(1):71-77.
  17. 17. Rudmik LR, Buie WD, Heine JA. Reoperation for intraluminal rectal cancer recurrence[J]. Dis Colon Rectum, 2005, 48(9):1752-1754.
  18. 18. 李保衛(wèi), 申連東, 任宏. 直腸癌術(shù)后局部復(fù)發(fā)再手術(shù)50例分析[J]. 陜西醫(yī)學(xué)雜志, 2010, 39(10):1424.
  19. 19. Henry LR, Sigurdson E, Ross E, et al. Hydronephrosis does not preclude curative resection of pelvic recurrences after colorectal surgery[J]. Ann Surg Oncol, 2005, 12(10):786-792.
  20. 20. 傅傳剛, 高顯華. 局部復(fù)發(fā)直腸癌再手術(shù)適應(yīng)證及手術(shù)方式的選擇[J]. 中國實(shí)用外科雜志, 2011, 31(4):287-289.
  21. 21. Mirnezami AH, Sagar PM. Surgery for recurrent rectal cancer:technical notes and management of complications[J]. Tech Coloproctol, 2010, 14(3):209-216.
  22. 22. Garcia-Aguilar J, Cromwell JW, Marra C, et al. Treatment of locally recurrent rectal cancer[J]. Dis Colon Rectum, 2001, 44(12):1743-1748.