• 1.中國醫(yī)科大學附屬第四醫(yī)院普外科(遼寧沈陽 110032);;
  • 2. 沈陽242醫(yī)院普外科(遼寧沈陽 110000);

目的  探討肝癌合并低血糖的診斷及治療。
方法  對中國醫(yī)科大學附屬第四醫(yī)院2010年1月至2013年4月期間收治的27例肝癌伴低血糖患者的臨床資料進行回顧性分析。
結果  27例患者中轉移性肝癌2例,原發(fā)性肝癌25例;其中伴肝硬變9例。所有患者均給予護肝、補充能量治療;22例行手術治療后血糖全部控制在正?;騼H輕度升高,5例因腫瘤無法切除而放棄手術治療,其中1例伴肝硬變肝癌患者2個月后再次低血糖癥狀發(fā)作后死亡。
結論  低血糖是肝癌少見的并發(fā)癥,早期診斷及治療有助于避免后遺癥的發(fā)生并改善預后。

引用本文: 郝建朋,張鵬,姚俊超,郭大偉,孫文郁,梁健,姜曉峰. 肝癌伴低血糖的診斷和治療△. 中國普外基礎與臨床雜志, 2013, 20(10): 1162-1164. doi: 復制

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6. Sorlini M, Benini F, Cravarezza P, et al. Hypoglycemia, an atypical early sign of hepatocellular carcinoma[J]. J GastrointestCancer, 2010, 41(3):209-211.
7. Gaudiani JL, Sabel AL, Mascolo M, et al. Severe anorexia nervosa:outcomes from a medical stabilization unit[J]. Int J Eat Disord, 2012, 45(1):85-92.
8. Lau CI, Wang HC, Hsu WC. Hypoglycemic encephalopathy as the initial presentation of hepatic tumor:a case report[J]. Neuro-logist, 2010, 16(3):206-207.
9. Cassiman D, Libbrecht L, Verslype C, et al. An adult malepatient with multiple adenomas and a hepatocellular carcinoma:mild glycogen storage disease typeⅠa[J]. J Hepatol, 2010, 53(1):.
10. Filippella M, Davì MV, Doveri G, et al. Hyperinsulinemic hypo-glycemia associated with ectopic Cushing’s syndrome due to a pancreatic endocrine tumor in a Type 2 diabetes mellitus patient:clinical implications of a rare association[J]. J Endocrinol Invest,.
11. Elhomsy GC, Eranki V, Albert SG, et al. “Hyper-warburgism,” a cause of asymptomatic hypoglycemia with lactic acidosis in a patient with non-Hodgkin’s lymphoma[J]. J Clin Endocrinol Metab, 2012, 97(12):4311-4316.
12. Córdoba J. New assessment of hepatic encephalopathy[J]. J Hepatol, 2011, 54(5):1030-1040.
13. Hsiao SY, Chen SF, Chang CC, et al. Central nervous system involvement in hepatocellular carcinoma:Clinical characteristics and comparison of intracranial and spinal metastatic groups[J]. J Clin Neurosci, 2011, 18(3) :364-368.
14. Cammu G, Vermeiren K, Lecomte P, et al. Perioperative blood glucose management in patients undergoing tumor hepatectomy[J]. J Clin Anesth, 2009, 21(5):329-335.
15. Kandil SB, Miksa M, Faustino EV. Control of serum glucose concentration in critical illness[J]. Curr Opin Pediatr, 2013, 25(3):297-303.
16. -217.
17. , 34(3):175-179.
  1. 1. Okushin K, Asaoka Y, Fukuda I, et al. IGF-II producing hepatocellular carcinoma treated with sorafenib:metabolic complications and a foresight to molecular targeting therapy to the IGF signal[J]. Case Rep Gastroenterol, 2012, 6(3):784-789.
  2. 2. Baertling F, Mayatepek E, Gerner P, et al. Liver cirrhosis in glycogen storage disease Ib[J]. Mol Genet Metab, 2013, 108(3):198-200.
  3. 3. Cherian AK, Briski KP. A2 noradrenergic nerve cell metabolic transducer and nutrient transporter adaptation to hypoglycemia:impact of estrogen[J]. J Neurosci Res, 2012, 90(7):1347-1358.
  4. 4. Froissart R, Piraud M, Boudjemline AM, et al. Glucose-6-phosphatase deficiency[J]. Orphanet J Rare Dis, 2011, 6:27.
  5. 5. Matsuyama M, Sugiura S, Kakita A, et al. Hepatocellular carc-inoma arising from ectopic liver tissue in the spleen producinginsulin-like growth factor II[J]. Pathol Res Pract, 2011, 207(2):124-126.
  6. 6. Sorlini M, Benini F, Cravarezza P, et al. Hypoglycemia, an atypical early sign of hepatocellular carcinoma[J]. J GastrointestCancer, 2010, 41(3):209-211.
  7. 7. Gaudiani JL, Sabel AL, Mascolo M, et al. Severe anorexia nervosa:outcomes from a medical stabilization unit[J]. Int J Eat Disord, 2012, 45(1):85-92.
  8. 8. Lau CI, Wang HC, Hsu WC. Hypoglycemic encephalopathy as the initial presentation of hepatic tumor:a case report[J]. Neuro-logist, 2010, 16(3):206-207.
  9. 9. Cassiman D, Libbrecht L, Verslype C, et al. An adult malepatient with multiple adenomas and a hepatocellular carcinoma:mild glycogen storage disease typeⅠa[J]. J Hepatol, 2010, 53(1):.
  10. 10. Filippella M, Davì MV, Doveri G, et al. Hyperinsulinemic hypo-glycemia associated with ectopic Cushing’s syndrome due to a pancreatic endocrine tumor in a Type 2 diabetes mellitus patient:clinical implications of a rare association[J]. J Endocrinol Invest,.
  11. 11. Elhomsy GC, Eranki V, Albert SG, et al. “Hyper-warburgism,” a cause of asymptomatic hypoglycemia with lactic acidosis in a patient with non-Hodgkin’s lymphoma[J]. J Clin Endocrinol Metab, 2012, 97(12):4311-4316.
  12. 12. Córdoba J. New assessment of hepatic encephalopathy[J]. J Hepatol, 2011, 54(5):1030-1040.
  13. 13. Hsiao SY, Chen SF, Chang CC, et al. Central nervous system involvement in hepatocellular carcinoma:Clinical characteristics and comparison of intracranial and spinal metastatic groups[J]. J Clin Neurosci, 2011, 18(3) :364-368.
  14. 14. Cammu G, Vermeiren K, Lecomte P, et al. Perioperative blood glucose management in patients undergoing tumor hepatectomy[J]. J Clin Anesth, 2009, 21(5):329-335.
  15. 15. Kandil SB, Miksa M, Faustino EV. Control of serum glucose concentration in critical illness[J]. Curr Opin Pediatr, 2013, 25(3):297-303.
  16. 16. -217.
  17. 17. , 34(3):175-179.