陸路 1 , 王洋 1 , 羅軍 1 , 王海東 2 , 李新喜 1 , 白超 1 , 王可 1 , 黃杰 1
  • 1.新疆醫(yī)科大學(xué)第一附屬醫(yī)院血管甲狀腺外科（新疆烏魯木齊 830054）;;
  • 2.海南省農(nóng)墾總醫(yī)院肝膽外科（海南海口 570311）;

目的 　探討靜脈血栓形成的復(fù)發(fā)因素。
方法 　檢索與靜脈血栓復(fù)發(fā)因素相關(guān)文獻(xiàn)，通過(guò)meta分析判斷多種因素與首次靜脈血栓形成后復(fù)發(fā)的關(guān)系。
結(jié)果 　共納入12篇相關(guān)文獻(xiàn)，meta分析結(jié)果顯示，首次靜脈血栓治療后復(fù)發(fā)與男性、年齡＜50歲、伴發(fā)惡性腫瘤或抗磷脂綜合征相關(guān)；與首次靜脈血栓類型和有無(wú)誘因無(wú)明顯相關(guān)性。
結(jié)論 　靜脈血栓復(fù)發(fā)與多因素相關(guān)，對(duì)存在復(fù)發(fā)因素的患者應(yīng)適當(dāng)延長(zhǎng)抗凝時(shí)間，預(yù)防血栓復(fù)發(fā)。

引用本文： 陸路,王洋,羅軍,王海東,李新喜,白超,王可,黃杰. 靜脈血栓形成復(fù)發(fā)因素的meta分析. 中國(guó)普外基礎(chǔ)與臨床雜志, 2013, 20(7): 787-792. doi: 復(fù)制

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15. Spencer FA， Gore JM， Lessard D， et al. Patient outcomes after deep vein thrombosis and pulmonary embolism：the Worcester venous Thromboembolism Study[J]. Arch Intern Med， 2008， 168(4)：425-430.
16. Iorio A， Kearon C， Filippucci E， et al. Risk of recurrence after a first episode of symptomatic venous thromboembolism provoked by a transient risk factor：a systematic review[J]. Arch Intern Med， 2010， 170(19)：1710-1716.
17. Kearon C， Gent M， Hirsh J， et al. A comparison of three months of anticoagulation with extended anticoagulation for a first episode of idiopathic venous thromboembolism[J]. N Engl J Med， 1999，.
18. Rosendaal FR. Risk factors for venous thrombotic disease[J]. Thromb Haemost， 1999， 82(2)：610-619.
19. McRae S， Tran H， Schulman S， et al. Effect of patient’s sex on risk of recurrent venous thromboembolism：a meta-analysis[J]. Lancet， 2006， 368(9533)：371-378.
20. Lijfering WM， Rosendaal FR， Cannegieter SC. Risk factors for venous thrombosis—current understanding from an epidemiolo-gical point of view[J]. Br J Haematol， 2010， 149(6)：824-833.
21. White RH， Romano PS， Zhou H， et al. Incidence and time course of thromboembolic outcomes following total hip or knee arthroplasty[J]. Arch Intern Med， 1998， 158(14)：1525-1531.
22. Heit JA， Mohr DN， Silverstein MD， et al. Predictors of recurrenceafter deep vein thrombosis and pulmonary embolism：a population-based cohort study[J]. Arch Intern Med， 2000， 160(6)：761-768.
23. Kearon C， Kahn SR， Agnelli G， et al. Antithrombotic therapy for venous thromboembolic disease：American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)[J]. Chest. 2008， 133(6 Suppl)：454S-545S.
24. Research Committee of the British Thoracic Society. Optimum duration of anticoagulation for deep-vein thrombosis and pulmonaryembolism[J]. Lancet， 1992， 340(8824)：873-876.
25. Brill-Edwards P， Ginsberg JS， Gent M， et al. Safety of withholding heparin in pregnant women with a history of venous thromboembolism. Recurrence of Clot in This Pregnancy Study Group[J]. N Engl J Med， 2000， 343(20)：1439-1444.
26. Rosove MH， Brewer PM. Antiphospholipid thrombosis：clinicalcourse after the first thrombotic event in 70 patients[J]. Ann InternMed， 1992， 117(4)：303-308.
27. Ho WK， Hankey GJ， Quinlan DJ， et al. Risk of recurrent venous thromboembolism in patients with common thrombophilia：a syst-ematic review[J]. Arch Intern Med， 2006， 166(7)：729-736.
28. Zhu T， Martinez I， Emmerich J. venous thromboembolism：risk factors for recurrence[J]. Arterioscler Thromb Vasc Biol， 2009， 29(3)：298-310.
29. (12)：901-907.
  1. 1. Anderson Jr FA， Spencer FA. Risk factors for venous thromboembolism[J]. Circulation， 2003， 107(23 Suppl 1)：I9- I16.
  2. 2. Olsen AH， Njor SH， Verjborg I， et al. Breast cancer mortality inCopenhagen after introduction of mammography screening：cohortstudy[J]. Br Med J， 2005， 330(7485)：220.
  3. 3. (12)：2152-2155.
  4. 4. Naess IA， Christiansen SC， Romundstad P， et al. Incidence and mortality of venous thrombosis：a population-based study[J]. J Thromb Haemost， 2007， 5(4)：692-699.
  5. 5. Kahn SR. The post-thrombotic syndrome：the forgotten morbidity of deep venous thrombosis[J]. J Thromb Thrombolysis， 21(1)：41-48.
  6. 6. Baglin T， Luddington R， Brown K， et al. High risk of recurrentvenous thromboembolism in men[J]. J Thromb Haemost， 2004，.
  7. 7. Christiansen SC， Lijfering WM， Helmerhorst FM， et al. Sex difference in risk of recurrent venous thrombosis and the risk profile for a second event[J]. J Thromb Haemost， 2010， 8(10)：2159-2168.
  8. 8. Hansson PO， Sörbo J， Eriksson H. Recurrent venous thromboembolism after deep vein thrombosis：incidence and risk factors[J]. Arch Intern Med， 2000， 160(6)：769-774.
  9. 9. Kyrle PA， Minar E， Bialonczyk C， et al. The risk of recurrent venous thromboembolism in men and women[J]. N Engl J Med， 2004， 350(25)：2558-2563.
  10. 10. Olié V， Zhu T， Martinez I， et al. Sex-specific risk factors for recurrent venous thromboembolism[J]. Thromb Res， 2012， 130 (1) ：16-20.
  11. 11. Tagalakis V， Kondal D， Ji Y， et al. Men had a higher risk of recu-rrent venous thromboembolism than women：a large population study[J]. Gend Med， 2012， 9(1)：33-43.
  12. 12. Kim TM， Kim JS， Han SW， et al. Clinical predictors of recurrentvenous thromboembolism：a single institute experience in Korea[J]. Thromb Res， 2009， 123(3)：436-443.
  13. 13. Prandoni P， Noventa F， Ghirarduzzi A， et al. The risk of recurrentvenous thromboembolism after discontinuing anticoagulation inpatients with acute proximal deep vein thrombosis or pulmonary embolism. A prospective cohort study in 1 626 patients[J]. Haem-atologica， 2007， 92(2)：199-205.
  14. 14. Eichinger S， Weltermann A， Minar E， et al. Symptomatic pulmo-nary embolism and the risk of recurrent venous thromboembolism[J]. Arch Intern Med， 2004， 164(1)：92-96.
  15. 15. Spencer FA， Gore JM， Lessard D， et al. Patient outcomes after deep vein thrombosis and pulmonary embolism：the Worcester venous Thromboembolism Study[J]. Arch Intern Med， 2008， 168(4)：425-430.
  16. 16. Iorio A， Kearon C， Filippucci E， et al. Risk of recurrence after a first episode of symptomatic venous thromboembolism provoked by a transient risk factor：a systematic review[J]. Arch Intern Med， 2010， 170(19)：1710-1716.
  17. 17. Kearon C， Gent M， Hirsh J， et al. A comparison of three months of anticoagulation with extended anticoagulation for a first episode of idiopathic venous thromboembolism[J]. N Engl J Med， 1999，.
  18. 18. Rosendaal FR. Risk factors for venous thrombotic disease[J]. Thromb Haemost， 1999， 82(2)：610-619.
  19. 19. McRae S， Tran H， Schulman S， et al. Effect of patient’s sex on risk of recurrent venous thromboembolism：a meta-analysis[J]. Lancet， 2006， 368(9533)：371-378.
  20. 20. Lijfering WM， Rosendaal FR， Cannegieter SC. Risk factors for venous thrombosis—current understanding from an epidemiolo-gical point of view[J]. Br J Haematol， 2010， 149(6)：824-833.
  21. 21. White RH， Romano PS， Zhou H， et al. Incidence and time course of thromboembolic outcomes following total hip or knee arthroplasty[J]. Arch Intern Med， 1998， 158(14)：1525-1531.
  22. 22. Heit JA， Mohr DN， Silverstein MD， et al. Predictors of recurrenceafter deep vein thrombosis and pulmonary embolism：a population-based cohort study[J]. Arch Intern Med， 2000， 160(6)：761-768.
  23. 23. Kearon C， Kahn SR， Agnelli G， et al. Antithrombotic therapy for venous thromboembolic disease：American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)[J]. Chest. 2008， 133(6 Suppl)：454S-545S.
  24. 24. Research Committee of the British Thoracic Society. Optimum duration of anticoagulation for deep-vein thrombosis and pulmonaryembolism[J]. Lancet， 1992， 340(8824)：873-876.
  25. 25. Brill-Edwards P， Ginsberg JS， Gent M， et al. Safety of withholding heparin in pregnant women with a history of venous thromboembolism. Recurrence of Clot in This Pregnancy Study Group[J]. N Engl J Med， 2000， 343(20)：1439-1444.
  26. 26. Rosove MH， Brewer PM. Antiphospholipid thrombosis：clinicalcourse after the first thrombotic event in 70 patients[J]. Ann InternMed， 1992， 117(4)：303-308.
  27. 27. Ho WK， Hankey GJ， Quinlan DJ， et al. Risk of recurrent venous thromboembolism in patients with common thrombophilia：a syst-ematic review[J]. Arch Intern Med， 2006， 166(7)：729-736.
  28. 28. Zhu T， Martinez I， Emmerich J. venous thromboembolism：risk factors for recurrence[J]. Arterioscler Thromb Vasc Biol， 2009， 29(3)：298-310.
  29. 29. (12)：901-907.