• 南京醫(yī)科大學附屬南京醫(yī)院(南京市第一醫(yī)院)普外科(江蘇南京 210006);

目的  探討胃癌術后影響胃癌患者生存的因素。
方法  將2004年1月至2009年12月期間在筆者所在醫(yī)院行手術治療并獲隨訪的351例胃癌患者作為研究對象,對其臨床病理資料及隨訪資料進行單因素和多因素分析。
結果  單因素分析顯示患者年齡以及腫瘤部位、T分期、N分期、TNM分期和分化程度與預后有關(P<0.05);多因素分析顯示腫瘤部位、T分期、N分期和術后化療是影響胃癌術后生存率的獨立因素(P<0.05)。
結論  腫瘤部位、浸潤深度、淋巴結轉移率及術后輔助化療是影響胃癌術后生存的重要因素。對于有淋巴結轉移或處于TNM Ⅲ期的胃癌患者,術后化療可以提高其生存率。

引用本文: 王蓓,呂成余,謝洪虎. 351 例胃癌術后患者的預后因素分析. 中國普外基礎與臨床雜志, 2012, 19(7): 743-748. doi: 復制

1. Jemal A, Siegel R, Ward E, et al. Cancer Statistics, 2008 [J].CA Cancer J Clin, 2008, 58:71-96.
2. 孫秀娣, 牧人, 周有尚, 等. 中國胃癌死亡率20 年變化情況分析及其發(fā)展趨勢預測 [J]. 中華腫瘤雜志, 2004, 26(5):4-9.
3. Hmilton SR, Aahonen LA. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Digestive System [M]. Lyon:IARC Press, 2000:38-39.
4. Washington K. 7th Edition of the AJCC Cancer Staging Manual:Stomach [J]. Ann Surg Oncol, 2010, 17(12):3077-3079.
5. Ling Yang. Incidence and mortality of gastric cancer in China[J]. World J Gastroenterol, 2006, 12(1):17-20.
6. Steevens J, Schouten LJ, Goldbohm RA, et al. Alcohol consumption,cigarette smoking and risk of subtypes of oesophageal and gastric cancer:a prospective cohort study [J]. Gut, 2010,59(1):39-48.
7. Furukawa H, Iwanaga T, Koyama H, et al. Effects of sex hormones on carcinogenesis in the stomach of rats [J]. Cancer Res,1982,42(12):5181-5182.
8. Lee SA, Kang D, Shim KN, et al. Effect of diet and helicobacter pylori inection to the risk of early gastric cancer [J]. J Epidemiol,2003, 13(9):162-168.
9. Maguire A, Porta M, Sanz-Anquela JM, et al. Sex as a prognostic factor in gastric cancer [J]. Eur J Cancer, 1996, 32A(8):1303-1309.
10. Alici S, Kaya S, Izmirli M, et al. Analysis of survival factors in patients with advanced-stage gastric adenocarcinoma [J]. Med Sci Monit, 2006, 12(5):221-229.
11. 彭俊生, 詹文華, 陳正煊, 等. 不同年齡段胃癌患者的臨床病理特點與預后分析 [J]. 中華胃腸外科雜志, 2004, 7(5):349-352.
12. Rabunal RR, Pita SF, Rigueiro MT, et al. Presentation and Prognosis of gastric cancer in patients aged 80 years and older[J].World J Surg, 2004, 28(2):155-159.
13. Cunningham SC, Kamangar F, Kim MP, et al. Survival after gastric adenocarcinoma resection:eighteen-year experience at a single institution [J]. J Gastrointest Surg, 2005, 9(5):718-725.
14. Hassan HA, Sharma VK, Raufman JP. Changing trends in gastric carcinoma at a university medical center:a twelve year retrospective analysis [J]. J Clin Gastroenterol, 2001, 32(1):37-40.
15. Pacelli F, Papa V, Caprino P, et al. Proximal compared with distal gastric cancer:multivariate analysis of prognostic factors [J]. Am Surg, 2001, 67(7):697-703.
16. 封凱, 劉智毅, 林飛. 近遠端胃癌預后差異及臨床病理特點分析 [J]. 中華現(xiàn)代外科學雜志, 2009, 6(9):533-537.
17. Piso P, Werner U, Lang H, et al. Proxmal versus distal gastric carcinoma——what are the differences?[ J]. Ann Surg Oncol,2000, 7(7):520-525.
18. Siewert JR, Bottcher K, Stein HJ, et al. Relevant prognostic factors in gastric cancer:ten-years results of the German Gastric Cancer Study [J]. Ann Surg, 1998, 228(4):449-461.
19. 馮潤華, 朱正綱, 燕敏, 等. 淋巴結轉移率對T2 ~ T3 期胃癌患者預后評估的價值 [J]. 中華胃腸外科雜志, 2007, 10(5):431-435.
20. 謝洪虎, 呂成余, 陳維, 等. 958 例胃癌臨床病理資料分析 [J]. 中國普外基礎與臨床雜志, 2011, 18(2):153-158.
21. Maruyama K. The most important prognostic factors for gastric cancer patients:a study using univariate and multivariate analyses [J]. Scand J Gastroenterol, 1987, 22:63-68.
22. 詹友慶, 孫曉衛(wèi), 李威. 影響根治術后胃癌預后的多因素分析 [J]. 癌癥, 2005, 24(5):596.
23. 陳凜, 張勇, 衛(wèi)勃, 等. 2335 例胃癌外科治療的臨床分析 [J].中華胃腸外科雜志, 2007, 10(5):421-424.
24. Panzini I, Gianni L, Fattori PP, et al. Adjuvant chemotherapy in agstric cancer:a meta-analysis of randomised trials and a comparison with privious meta-analyses [J]. Tumori, 2002, 88(1):21-27.
25. Sun P, Xiang JB, Chen ZY. Meta-analysis of adjuvant chemotherapy after radical surgery for advanced gastric cancer [J]. Br J Surg, 2009, 96(1):26-33.
  1. 1. Jemal A, Siegel R, Ward E, et al. Cancer Statistics, 2008 [J].CA Cancer J Clin, 2008, 58:71-96.
  2. 2. 孫秀娣, 牧人, 周有尚, 等. 中國胃癌死亡率20 年變化情況分析及其發(fā)展趨勢預測 [J]. 中華腫瘤雜志, 2004, 26(5):4-9.
  3. 3. Hmilton SR, Aahonen LA. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Digestive System [M]. Lyon:IARC Press, 2000:38-39.
  4. 4. Washington K. 7th Edition of the AJCC Cancer Staging Manual:Stomach [J]. Ann Surg Oncol, 2010, 17(12):3077-3079.
  5. 5. Ling Yang. Incidence and mortality of gastric cancer in China[J]. World J Gastroenterol, 2006, 12(1):17-20.
  6. 6. Steevens J, Schouten LJ, Goldbohm RA, et al. Alcohol consumption,cigarette smoking and risk of subtypes of oesophageal and gastric cancer:a prospective cohort study [J]. Gut, 2010,59(1):39-48.
  7. 7. Furukawa H, Iwanaga T, Koyama H, et al. Effects of sex hormones on carcinogenesis in the stomach of rats [J]. Cancer Res,1982,42(12):5181-5182.
  8. 8. Lee SA, Kang D, Shim KN, et al. Effect of diet and helicobacter pylori inection to the risk of early gastric cancer [J]. J Epidemiol,2003, 13(9):162-168.
  9. 9. Maguire A, Porta M, Sanz-Anquela JM, et al. Sex as a prognostic factor in gastric cancer [J]. Eur J Cancer, 1996, 32A(8):1303-1309.
  10. 10. Alici S, Kaya S, Izmirli M, et al. Analysis of survival factors in patients with advanced-stage gastric adenocarcinoma [J]. Med Sci Monit, 2006, 12(5):221-229.
  11. 11. 彭俊生, 詹文華, 陳正煊, 等. 不同年齡段胃癌患者的臨床病理特點與預后分析 [J]. 中華胃腸外科雜志, 2004, 7(5):349-352.
  12. 12. Rabunal RR, Pita SF, Rigueiro MT, et al. Presentation and Prognosis of gastric cancer in patients aged 80 years and older[J].World J Surg, 2004, 28(2):155-159.
  13. 13. Cunningham SC, Kamangar F, Kim MP, et al. Survival after gastric adenocarcinoma resection:eighteen-year experience at a single institution [J]. J Gastrointest Surg, 2005, 9(5):718-725.
  14. 14. Hassan HA, Sharma VK, Raufman JP. Changing trends in gastric carcinoma at a university medical center:a twelve year retrospective analysis [J]. J Clin Gastroenterol, 2001, 32(1):37-40.
  15. 15. Pacelli F, Papa V, Caprino P, et al. Proximal compared with distal gastric cancer:multivariate analysis of prognostic factors [J]. Am Surg, 2001, 67(7):697-703.
  16. 16. 封凱, 劉智毅, 林飛. 近遠端胃癌預后差異及臨床病理特點分析 [J]. 中華現(xiàn)代外科學雜志, 2009, 6(9):533-537.
  17. 17. Piso P, Werner U, Lang H, et al. Proxmal versus distal gastric carcinoma——what are the differences?[ J]. Ann Surg Oncol,2000, 7(7):520-525.
  18. 18. Siewert JR, Bottcher K, Stein HJ, et al. Relevant prognostic factors in gastric cancer:ten-years results of the German Gastric Cancer Study [J]. Ann Surg, 1998, 228(4):449-461.
  19. 19. 馮潤華, 朱正綱, 燕敏, 等. 淋巴結轉移率對T2 ~ T3 期胃癌患者預后評估的價值 [J]. 中華胃腸外科雜志, 2007, 10(5):431-435.
  20. 20. 謝洪虎, 呂成余, 陳維, 等. 958 例胃癌臨床病理資料分析 [J]. 中國普外基礎與臨床雜志, 2011, 18(2):153-158.
  21. 21. Maruyama K. The most important prognostic factors for gastric cancer patients:a study using univariate and multivariate analyses [J]. Scand J Gastroenterol, 1987, 22:63-68.
  22. 22. 詹友慶, 孫曉衛(wèi), 李威. 影響根治術后胃癌預后的多因素分析 [J]. 癌癥, 2005, 24(5):596.
  23. 23. 陳凜, 張勇, 衛(wèi)勃, 等. 2335 例胃癌外科治療的臨床分析 [J].中華胃腸外科雜志, 2007, 10(5):421-424.
  24. 24. Panzini I, Gianni L, Fattori PP, et al. Adjuvant chemotherapy in agstric cancer:a meta-analysis of randomised trials and a comparison with privious meta-analyses [J]. Tumori, 2002, 88(1):21-27.
  25. 25. Sun P, Xiang JB, Chen ZY. Meta-analysis of adjuvant chemotherapy after radical surgery for advanced gastric cancer [J]. Br J Surg, 2009, 96(1):26-33.