• 1.河北北方學院(河北張家口 075000);;
  • 2.解放軍第251醫(yī)院普外科(河北張家口 075000);

目的介紹連環(huán)蛋白家族新成員p120-連環(huán)蛋白(p120-catenin，p120ctn)及其在腫瘤研究中的進展。方法查閱近年來國內(nèi)、外有關(guān)對p120ctn研究的文獻并作綜述。結(jié)果①p120ctn參與鈣黏蛋白連環(huán)蛋白復(fù)合體的形成，參與細胞生長、增殖和黏附連接; ②調(diào)控Rho GTP 酶的活性，促進細胞運動性; ③與核內(nèi)轉(zhuǎn)錄因子Kaiso結(jié)合形成Kaiso-p120ctn復(fù)合體，參與基因轉(zhuǎn)錄的調(diào)控; ④參與血管內(nèi)皮生長因子誘導(dǎo)的血管新生過程; ⑤參與炎癥、細胞惡變以及腫瘤侵襲、轉(zhuǎn)移過程。結(jié)論p120ctn作為連環(huán)蛋白家族中的一個新成員，依靠它的細胞定位參與多種生物過程，從分子水平深入了解p120ctn的生物學功能及作用機理，有利于從p120ctn的異常改變判斷腫瘤的發(fā)生和發(fā)展，為腫瘤的預(yù)防和治療提供新的手段。

引用本文： 南潤玲,尚培中. 連環(huán)蛋白家族的新成員——p120-連環(huán)蛋白. 中國普外基礎(chǔ)與臨床雜志, 2011, 18(4): 462-467. doi: 復(fù)制

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  1. 1. Cheung LW, Leung PC, Wong AS. Cadherin switching and activation of p120 catenin signaling are mediators of gonadotropinreleasing hormone to promote tumor cell migration and invasion in ovarian cancer [J]. Oncogene, 2010, 29(16): 24272440.
  2. 2. Albert B, Reynolds AB. p120catenin: Past and present [J]. Biochim Biophys Acta, 2007, 1773(1): 27.
  3. 3. 歐海玲, 覃宇周, 張錫流. Ecadherin/p120ctn與腫瘤關(guān)系的研究進展 [J]. 中國臨床新醫(yī)學, 2009, 2(2): 201205.
  4. 4. Hatzfel DM. The p120 family of cell adhesion molecules [J]. Eur J Cell Biol, 2005, 84(23): 205214.
  5. 5. Grossmann KS, Grund C, Huelsken J, et al. Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation [J]. J Cell Biol, 2004, 167(1): 149160.
  6. 6. Ishiyama N, Lee SH, Liu S, et al. Dynamic and static interactions between p120 catenin and Ecadherin regulate the stability of cellcell adhesion [J]. Cell, 2010, 141(1): 117128.
  7. 7. Xiao K, Oas RG, Chiasson CM, et al. Role of p120catenin in cadherin trafficking [J]. Biochim Biophys Acta, 2007, 1773(1): 816.
  8. 8. SmalleyFreed WG, Efimov A, Burnett PE, et al. p120catenin is essential for maintenance of barrier function and intestinal homeostasis in mice [J]. J Clin Invest, 2010, 120(6): 18241835.
  9. 9. Ichii T, Takeichi M. p120catenin regulates microtubule dynamics and cell migration in a cadherinindependent manner [J]. Genes Cells, 2007, 12(7): 827839.
  10. 10. Anastasiadis PZ. p120ctn: A nexus for contextual signaling via Rho GTPases [J]. Biochim Biophys Acta, 2007, 1773(1): 3446.
  11. 11. Kolanus W, Zeitlmann L. Regulation of integrin function by insideout signaling mechanisms [J]. Curr Top Microbiol Immunol, 1998, 231: 3349.
  12. 12. Fukumoto Y, Shintani Y, Reynolds AB, et al. The regulatory or phosphorylation domain of p120 catenin controls Ecadherin dynamics at the plasma membrane [J]. Exp Cell Res, 2008, 314(1): 5267.
  13. 13. Brown MV, Burnett PE, Denning MF, et al. PDGF receptor activation induces p120catenin phosphorylation at serine 879 via a PKCalphadependent pathway [J]. Exp Cell Res, 2009, 315(1): 3949.
  14. 14. Soto E, Yanagisawa M, Marlow LA, et al. p120 catenin induces opposing effects on tumor cell growth depending on Ecadherin expression [J]. J Cell Biol, 2008, 183(4): 737749.
  15. 15. Zhang J, O’Donnell JJ 3rd, Holian O, et al. P120 catenin represses transcriptional activity through Kaiso in endothelial cells [J]. Microvasc Res, 2010, 80(2): 233239.
  16. 16. Fukuyama T, Ogita H, Kawakatsu T, et al. Activation of Rac by cadherin through the cSrcRap1phosphatidylinositol 3kinaseVav2 pathway [J]. Oncogene, 2006, 25(1): 819.
  17. 17. Daniel JM. Dancing in and out of the nucleus: p120(ctn) and the transcription factor Kaiso [J]. Biochim Biophys Acta, 2007, 1773(1): 5968.
  18. 18. Park JI, Kim SW, Lyons JP, et al. Kaiso/p120catenin and TCF/betacatenin complexes coordinately regulate canonical Wnt gene targets [J]. Dev Cell, 2005, 8(6): 843854.
  19. 19. Dai SD, Wang Y, Jiang GY, et al. Kaiso is expressed in lung cancer: its expression and localization is affected by p120ctn [J]. Lung Cancer, 2010, 67(2): 205215.
  20. 20. 羅小華, 劉文勵. P120ctn在血管內(nèi)皮生長因子誘導(dǎo)血管生成中的作用 [J]. 臨床血液學雜志, 2006, 19(1): 5456.
  21. 21. Oas RG, Xiao K, Summers S, et al. p120Catenin is required for mouse vascular development [J]. Circ Res, 2010, 106(5): 941951.
  22. 22. Esser S, Lampugnani MG, Corada M, et al. Vascular endothelial growth factor induces VEcadherin tyrosine phosphorylation in endothelial cells [J]. J Cell Sci, 1998, 111(Pt 13): 18531865.
  23. 23. van Hengel J, van Roy F. Diverse functions of p120ctn in tumors [J]. Biochim Biophys Acta, 2007, 1773(1): 7888.
  24. 24. 黃華藝, 農(nóng)朝贊, 郭凌宵, 等. 肝癌細胞生物學行為改變涉及p120ctn酪氨酸磷酸化的研究 [J]. 中華醫(yī)學雜志, 2003, 83(20): 18011806.
  25. 25. Nong CZ, Pan LL, He WS, et al. P120ctn overexpression enhances beta catenin Ecadherin binding and down regulates expression of survivin and cyclin D1 in BEL7404 hepatoma cells [J]. World J Gastroenterol, 2006, 12(8): 11871191.
  26. 26. 農(nóng)朝贊, 黃嬋娟, 潘莉莉, 等. β連環(huán)蛋白在轉(zhuǎn)染p120ctn同工蛋白3A的肝癌細胞中的表達變化 [J]. 臨床與實驗病理學雜志, 2008, 24(6): 712715.
  27. 27. Zhai B, Yan HX, Liu SQ, et al. Reduced expression of Ecadherin/catenin complex in hepatocellular carcinomas [J]. World J Gastroenterol, 2008, 14(37): 56655673.
  28. 28. 張毅, 朱瑾, 楊占宇, 等. 連環(huán)蛋白P120在肝細胞癌中的表達及其意義 [J]. 消化外科, 2006, 5(6): 431434.
  29. 29. Karatzas G, Karayiannakis AJ, Syrigos KN, et al. Expression patterns of the Ecadherincatenin cellcell adhesion complex in gastric cancer [J]. Hepatogastroenterology, 2000, 47(35): 14651469.
  30. 30. Ogden SR, Wroblewski LE, Weydig C, et al. p120 and Kaiso regulate Helicobacter pyloriinduced expression of matrix metalloproteinase [J]. Mol Biol Cell, 2008,19(10): 41104121.
  31. 31. Jawhari AU, Noda M, Pignatelli M, et al. Upregulated cytoplasmic expression, with reduced membranous distribution, of the srcsubstrate p120 (ctn) in gastric carcinoma [J]. J Pathol, 1999, 189(2): 180185.
  32. 32. 虞志強. CDX2和p120catenin在胃癌組織中的臨床意義 [J]. 實用癌癥雜志, 2009, 24(6): 573575.
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