• 昆明醫(yī)學(xué)院第一附屬醫(yī)院胃腸甲狀腺外科（云南昆明 650031）;

目的研究galectin3的結(jié)構(gòu)、配體、組織分布與腫瘤的關(guān)系及其在幾種甲狀腺疾病中的表達(dá)情況。方法對相關(guān)文獻進行綜述分析。結(jié)果galectin-3 在正常細(xì)胞及腫瘤細(xì)胞中表達(dá)，調(diào)節(jié)細(xì)胞的生長、分化、黏附、凋亡和血管形成，參與腫瘤細(xì)胞的侵襲和轉(zhuǎn)移。結(jié)論galectin-3可作為鑒別甲狀腺良惡性腫瘤的參考指標(biāo)。

引用本文： 楊婷婷,程若川. galectin-3與幾種甲狀腺疾病的關(guān)系. 中國普外基礎(chǔ)與臨床雜志, 2011, 18(8): 907-910. doi: 復(fù)制

1. 楊國華， 劉海鷹． Galectin3與腫瘤的研究進展 [J]． 中華腫瘤防治雜志， 2007， 14（22）： 17551758．.
2. NangiaMakker P, Balan V, Raz A. Regulation of tumor progression by extracellular galectin3 [J]. Cancer Microenviron, 2008, 1(1): 4351.
3. Davidson PJ, Li SY, Lohse AG, et al. Transport of galectin3 between the nucleus and cytoplasm.I.conditions and signals for nuclear import [J]. Glycobiology, 2006, 16(7): 602611.
4. Li SY, Davidson PJ, Lin NY, et al. Transport of galectin3 between the nucleus and cytoplasm.Ⅱ.identification of the signal for nuclear export [J]. Glycobiology, 2006, 16(7): 612622.
5. Davidson PJ, Davis MJ, Patterson RJ, et al. Shuttling of galectin3 between the nucleus and cytoplasm [J]. Glycobiology, 2002, 12(5): 329337.
6. Dumic J, Dabelic S, Flgel M. Galectin3: an openended story [J]. Biochim Biophys Acta, 2006, 1760(4): 616635.
7. 楊志明， 伍曉汀， 何濤． Galectin3與腫瘤轉(zhuǎn)移 [J]． 中國普外基礎(chǔ)與臨床雜志， 2005， 12（3）： 310313．.
8. Hughes RC. Secretion of the galectin family of mammalian carbohydratebinding proteins [J]. Biochim Biophys Acta, 1999, 1473(1): 172185.
9. Nickel W. Unconventional secretory routes: direct protein export across the plasma membrane of mammalian cells [J]. Traffic, 2005, 6(8): 607614.
10. Gong HC, Honjo Y, Nangiamakker P, et al. The NH2 terminus of galectin3 governs cellular compartmentalization and functions in cancer cells [J]. Cancer Res, 1999, 59(24): 62396245.
11. Sato S, Hughes RC. Control of mac2 surface expression on murine macrophage cell lines [J]. Eur J Immunol, 1994, 24(1): 216221.
12. Mehul B, Hughes RC. Plasma membrane targetting, vesicular budding and release of galectin 3 from the cytoplasm of mammalian cells during secretion [J]. J Cell Sci, 1997, 110(Pt 10): 11691178.
13. Sato S, Hughes RC. Regulation of secretion and surface expression of Mac2, a galactosidebinding protein of macrophages [J]. J Biol Chem, 1994, 269(6): 44244430.
14. Théry C, Boussac M, Véron P, et al. Proteomic analysis of dendritic cellderived exosomes:a secreted subcellular compartment distinct from apoptotic vesicles [J]. J Immunol, 2001, 166(12): 73097318.
15. Baptiste TA, Ashley J, Saria M, et al. Mechanotransduction mediated secretion and uptake of galectin3 in breast carcinoma cells: implications in the extracellular functions of the lectin [J]. Exp Cell Res, 2007, 313(4): 652664.
16. Glinsky VV, Glinsky VV, RittenhouseOlson K, et al. The role of thomsenfriedenreich antigen in adhesion of human breast and prostate cancer cell s to the endothelium [J]. Cancer Res, 2001, 61(12): 48514857.
17. Stillman BN, Hsu DK, Pang M, et al. Galectin3 and galectin1 bind distinct cell surface glycoprotein receptors to induce T cell death [J]. J Immunol, 2006, 176(2): 778789.
18. Moiseeva EP, Javed Q, Spring EL, et al. Galectin 1 is involved in vascular smooth muscle cell proliferation [J]. Cardiovasc Res, 2000, 45(2): 493502.
19. Xu XC, Elnaggar AK, Lotan R. Differential expression of galectin1 and galectin3 in thyroid tumors. potential diagnostic implications [J]. Am J Pathol, 1995, 147(3): 815822.
20. 彭年春， 郭曉蕙， 袁振芳， 等． CD26/DPPⅣ,galectin3在甲狀腺乳頭狀癌的表達(dá)及意義[J]． 基礎(chǔ)醫(yī)學(xué)與臨床， 2009， 29（10）： 10791082．.
21. Kawachi K, Matsushita Y, Yonezawa S, et al. Galectin3 expression in various thyroid neoplasms and its possible role in metastasis formation [J]. Hum Pathol, 2000, 31(4): 428433.
22. Htwe TT, Karim N, Wong J, et al. Differential expression of galectin3 in advancing thyroid cancer cells: a clue toward understanding tumour progression and metastasis [J]. Singapore Med J, 2010, 51(11): 856859.
23. de Matos PS, Ferreira AP, de Oliveira Facuri F, et al. Usefulness of HBME1,cytokeratin 19 and galectin3 immunostaining in the diagnosis of thyroid malignancy [J]. Histopathology, 2005, 47(4): 391401.
24. Coli A, Bigotti G, Zucchetti F, et al. Galectin3, a marker of welldifferentiated thyroid carcinoma, is expressed in thyroid nodules with cytological atypia [J]. Histopathology, 2002, 40(1): 8087.
25. Cvejic D, Savin S, Paunovic I, et al. Immunohistochemical localization of galectin3 in malignant and benign human thyroid tissue [J]. Anticancer Res, 1998, 18(4A): 26372641.
26. Bartolazzi A, Gasbarri A, Mauro P, et al. Application of an immunodiagnostic method for improving preoperative diagnosis of nodular thyroid lesions [J]. Lancet, 2001, 357(9269): 16441650.
27. Saggiorato E, Cappia S, De GP, et al. Galectin3 as a presurgical immunocytodiagnostic marker of minimally invasive follicular thyroid carcinoma [J]. J Clin Endocrinol Metab, 2001, 86(11): 51525158.
28. 吳文君， 許嵐， 朱圣煒， 等． Galectin3對甲狀腺乳頭狀癌早期病變的診斷意義 [J]． 腫瘤防治研究， 2007， 34（7）： 518519, 548．.
29. 徐其銀． Galectin3和Cytokeratin19在橋本甲狀腺炎并發(fā)微小乳頭狀癌中不同區(qū)域的表達(dá) [D]． 昆明： 昆明醫(yī)學(xué)院， 2010．.
30. 張曉， 邱新光． 橋本病伴結(jié)節(jié)樣變中Galectin3, CK19的表達(dá)及其臨床意義 [J]． 中國實用醫(yī)刊， 2008， 35（12）： 910．.
31. Müller S, Schaffer T, Flogerzi B, et al. Galectin3 modulates T cell activity and is reduced in the inflamed intestinal epithelium in IBD [J]. Inflamm Bowel Dis, 2006, 12(7): 588597.
32. 王冬． Galectin3在甲狀腺炎中的表達(dá)及其臨床意義 [D]． 長春： 吉林大學(xué)， 2010．.
33. Das DK, Sharma PN. Diagnosis of papillary thyroid carcinoma in fine needle aspiration smears: factors that affect decision making [J]. Acta Cytol, 2009, 53(5): 497506.
34. Sapio MR, Guerra A, Posca D, et al. Combined analysis of galectin3 and brafv600E improves the accuracy of fineneedle aspiration biopsy with cytological findings suspicious for papillary thyroid carcinoma [J]. Endocr Relat Cancer, 2007, 14(4): 10891097.
35. Bartolazzi A, D’Alessandria C, Parisella MG, et al. Thyroid cancer imaging in vivo by targeting the antiapoptotic molecule galectin3 [J]. PLoS One, 2008, 3(11): e3768.
36. Nangiamakker P, Honjo Y, Sarvis R, et al. Galectin3 induces endothelial cell morphogenesis and angiogenesis [J]. Am J Pathol, 2000, 156(3): 899909.
37. Lin C, Whang EE, Donner DB, et al. Galectin3 targeted therapy with a small molecule inhibitor activates apoptosis and enhances both chemosensitivity and radiosensitivity in papillary thyroid cancer [J]. Molecular Cancer Research: MCR, 2009, 7(10): 16551662.
  1. 1. 楊國華， 劉海鷹． Galectin3與腫瘤的研究進展 [J]． 中華腫瘤防治雜志， 2007， 14（22）： 17551758．.
  2. 2. NangiaMakker P, Balan V, Raz A. Regulation of tumor progression by extracellular galectin3 [J]. Cancer Microenviron, 2008, 1(1): 4351.
  3. 3. Davidson PJ, Li SY, Lohse AG, et al. Transport of galectin3 between the nucleus and cytoplasm.I.conditions and signals for nuclear import [J]. Glycobiology, 2006, 16(7): 602611.
  4. 4. Li SY, Davidson PJ, Lin NY, et al. Transport of galectin3 between the nucleus and cytoplasm.Ⅱ.identification of the signal for nuclear export [J]. Glycobiology, 2006, 16(7): 612622.
  5. 5. Davidson PJ, Davis MJ, Patterson RJ, et al. Shuttling of galectin3 between the nucleus and cytoplasm [J]. Glycobiology, 2002, 12(5): 329337.
  6. 6. Dumic J, Dabelic S, Flgel M. Galectin3: an openended story [J]. Biochim Biophys Acta, 2006, 1760(4): 616635.
  7. 7. 楊志明， 伍曉汀， 何濤． Galectin3與腫瘤轉(zhuǎn)移 [J]． 中國普外基礎(chǔ)與臨床雜志， 2005， 12（3）： 310313．.
  8. 8. Hughes RC. Secretion of the galectin family of mammalian carbohydratebinding proteins [J]. Biochim Biophys Acta, 1999, 1473(1): 172185.
  9. 9. Nickel W. Unconventional secretory routes: direct protein export across the plasma membrane of mammalian cells [J]. Traffic, 2005, 6(8): 607614.
  10. 10. Gong HC, Honjo Y, Nangiamakker P, et al. The NH2 terminus of galectin3 governs cellular compartmentalization and functions in cancer cells [J]. Cancer Res, 1999, 59(24): 62396245.
  11. 11. Sato S, Hughes RC. Control of mac2 surface expression on murine macrophage cell lines [J]. Eur J Immunol, 1994, 24(1): 216221.
  12. 12. Mehul B, Hughes RC. Plasma membrane targetting, vesicular budding and release of galectin 3 from the cytoplasm of mammalian cells during secretion [J]. J Cell Sci, 1997, 110(Pt 10): 11691178.
  13. 13. Sato S, Hughes RC. Regulation of secretion and surface expression of Mac2, a galactosidebinding protein of macrophages [J]. J Biol Chem, 1994, 269(6): 44244430.
  14. 14. Théry C, Boussac M, Véron P, et al. Proteomic analysis of dendritic cellderived exosomes:a secreted subcellular compartment distinct from apoptotic vesicles [J]. J Immunol, 2001, 166(12): 73097318.
  15. 15. Baptiste TA, Ashley J, Saria M, et al. Mechanotransduction mediated secretion and uptake of galectin3 in breast carcinoma cells: implications in the extracellular functions of the lectin [J]. Exp Cell Res, 2007, 313(4): 652664.
  16. 16. Glinsky VV, Glinsky VV, RittenhouseOlson K, et al. The role of thomsenfriedenreich antigen in adhesion of human breast and prostate cancer cell s to the endothelium [J]. Cancer Res, 2001, 61(12): 48514857.
  17. 17. Stillman BN, Hsu DK, Pang M, et al. Galectin3 and galectin1 bind distinct cell surface glycoprotein receptors to induce T cell death [J]. J Immunol, 2006, 176(2): 778789.
  18. 18. Moiseeva EP, Javed Q, Spring EL, et al. Galectin 1 is involved in vascular smooth muscle cell proliferation [J]. Cardiovasc Res, 2000, 45(2): 493502.
  19. 19. Xu XC, Elnaggar AK, Lotan R. Differential expression of galectin1 and galectin3 in thyroid tumors. potential diagnostic implications [J]. Am J Pathol, 1995, 147(3): 815822.
  20. 20. 彭年春， 郭曉蕙， 袁振芳， 等． CD26/DPPⅣ,galectin3在甲狀腺乳頭狀癌的表達(dá)及意義[J]． 基礎(chǔ)醫(yī)學(xué)與臨床， 2009， 29（10）： 10791082．.
  21. 21. Kawachi K, Matsushita Y, Yonezawa S, et al. Galectin3 expression in various thyroid neoplasms and its possible role in metastasis formation [J]. Hum Pathol, 2000, 31(4): 428433.
  22. 22. Htwe TT, Karim N, Wong J, et al. Differential expression of galectin3 in advancing thyroid cancer cells: a clue toward understanding tumour progression and metastasis [J]. Singapore Med J, 2010, 51(11): 856859.
  23. 23. de Matos PS, Ferreira AP, de Oliveira Facuri F, et al. Usefulness of HBME1,cytokeratin 19 and galectin3 immunostaining in the diagnosis of thyroid malignancy [J]. Histopathology, 2005, 47(4): 391401.
  24. 24. Coli A, Bigotti G, Zucchetti F, et al. Galectin3, a marker of welldifferentiated thyroid carcinoma, is expressed in thyroid nodules with cytological atypia [J]. Histopathology, 2002, 40(1): 8087.
  25. 25. Cvejic D, Savin S, Paunovic I, et al. Immunohistochemical localization of galectin3 in malignant and benign human thyroid tissue [J]. Anticancer Res, 1998, 18(4A): 26372641.
  26. 26. Bartolazzi A, Gasbarri A, Mauro P, et al. Application of an immunodiagnostic method for improving preoperative diagnosis of nodular thyroid lesions [J]. Lancet, 2001, 357(9269): 16441650.
  27. 27. Saggiorato E, Cappia S, De GP, et al. Galectin3 as a presurgical immunocytodiagnostic marker of minimally invasive follicular thyroid carcinoma [J]. J Clin Endocrinol Metab, 2001, 86(11): 51525158.
  28. 28. 吳文君， 許嵐， 朱圣煒， 等． Galectin3對甲狀腺乳頭狀癌早期病變的診斷意義 [J]． 腫瘤防治研究， 2007， 34（7）： 518519, 548．.
  29. 29. 徐其銀． Galectin3和Cytokeratin19在橋本甲狀腺炎并發(fā)微小乳頭狀癌中不同區(qū)域的表達(dá) [D]． 昆明： 昆明醫(yī)學(xué)院， 2010．.
  30. 30. 張曉， 邱新光． 橋本病伴結(jié)節(jié)樣變中Galectin3, CK19的表達(dá)及其臨床意義 [J]． 中國實用醫(yī)刊， 2008， 35（12）： 910．.
  31. 31. Müller S, Schaffer T, Flogerzi B, et al. Galectin3 modulates T cell activity and is reduced in the inflamed intestinal epithelium in IBD [J]. Inflamm Bowel Dis, 2006, 12(7): 588597.
  32. 32. 王冬． Galectin3在甲狀腺炎中的表達(dá)及其臨床意義 [D]． 長春： 吉林大學(xué)， 2010．.
  33. 33. Das DK, Sharma PN. Diagnosis of papillary thyroid carcinoma in fine needle aspiration smears: factors that affect decision making [J]. Acta Cytol, 2009, 53(5): 497506.
  34. 34. Sapio MR, Guerra A, Posca D, et al. Combined analysis of galectin3 and brafv600E improves the accuracy of fineneedle aspiration biopsy with cytological findings suspicious for papillary thyroid carcinoma [J]. Endocr Relat Cancer, 2007, 14(4): 10891097.
  35. 35. Bartolazzi A, D’Alessandria C, Parisella MG, et al. Thyroid cancer imaging in vivo by targeting the antiapoptotic molecule galectin3 [J]. PLoS One, 2008, 3(11): e3768.
  36. 36. Nangiamakker P, Honjo Y, Sarvis R, et al. Galectin3 induces endothelial cell morphogenesis and angiogenesis [J]. Am J Pathol, 2000, 156(3): 899909.
  37. 37. Lin C, Whang EE, Donner DB, et al. Galectin3 targeted therapy with a small molecule inhibitor activates apoptosis and enhances both chemosensitivity and radiosensitivity in papillary thyroid cancer [J]. Molecular Cancer Research: MCR, 2009, 7(10): 16551662.