• 1.四川大學(xué)華西醫(yī)院甲狀腺乳腺外科（成都 610041）;;
  • 2.四川大學(xué)華西口腔醫(yī)學(xué)院（成都 610041）;

目的 初步了解砂粒體在人體腫瘤中形成機(jī)理的研究的最新進(jìn)展及與之相關(guān)的問(wèn)題。方法 參閱、分析、比較國(guó)內(nèi)、外相關(guān)文獻(xiàn)，并進(jìn)行歸納總結(jié)，再加以綜述。結(jié)果 砂粒體是某些腫瘤組織中的特殊病理性鈣化，在顯微鏡下均呈同心圓層狀排列的鈣化灶,常見(jiàn)于甲狀腺乳頭狀癌、腦膜瘤、卵巢漿液性乳頭狀癌等。結(jié)論 砂粒體雖在顯微鏡下均呈同心圓層狀排列的鈣化灶，但在不同的腫瘤中其形成過(guò)程卻不盡相同。全面客觀地認(rèn)識(shí)砂粒體的形成將有助于對(duì)腫瘤的診斷、治療。

引用本文： 李曉龍,李志輝. 淺析砂粒體在人體腫瘤中的形成機(jī)理及相關(guān)問(wèn)題. 中國(guó)普外基礎(chǔ)與臨床雜志, 2010, 17(11): 1216-1218. doi: 復(fù)制

1. Das DK. Psammoma body: a product of dystrophic calcification or of a biologically active process that aims at limiting the growth and spread of tumor? [J]. Diagn Cytopathol, 2009; 37(7): 534-541.
2. Gonzalez JE, Caldwell RG, Valaitis J. Calcium oxalate cry-stals in the breast. Pathology and significance [J]. Am J Surg Pathol, 1991; 15(6): 586-591.
3. Frappart L, Boudeulle M, Boumendil J, et al. Structure and composition of microcalcifications in benign and malignant lesions of the breast: study by light microscopy, transmission and scanning electron microscopy, microprobe analysis, and X-ray diffraction [J]. Hum Pathol, 1984; 15(9): 880-889.
4. Lanyi M. Microcalcifications in the breast-a blessing or a curse? A critical review [J]. Diagn Imaging Clin Med, 1985; 54(3-4): 126-145.
5. Fandos-Morera A, Prats-Esteve M, Tura-Soteras JM, et al. Breast tumors: composition of microcalcifications [J]. Radiology, 1988; 169(2): 325-327.
6. 官青, 吳毅. 砂粒體在甲狀腺癌研究中的進(jìn)展 [J]. 中國(guó)癌癥雜志， 2009； 19(8): 637-640.
7. Fadare O, Chacho MS, Parkash V. Psammoma bodies in cervicovaginal smears: significance and practical implications for diagnostic cytopathology [J]. Adv Anat Pathol, 2004; 11(5): 250-261.
8. Kubota T, Hirano A, Sato K, et al. Fine structure of psammoma bodies at the outer aspect of blood vessels in meningioma [J]. Acta Neuropathol, 1985; 66(2): 163-166.
9. 陳昊. 砂粒體在腫瘤中的形成與臨床意義 [J]. 河南腫瘤學(xué)雜志, 1999； 12(2): 148-149.
10. Johannessen JV, Sobrinho-Simes M. The origin and significance of thyroid psammoma bodies [J]. Lab Invest, 1980; 43(3): 287-296.
11. Cameron RI, McCluggage WG. Extensive psammomatous calcification of the uterus and cervix associated with a uterine serous carcinoma [J]. J Clin Pathol, 2004; 57(8): 888-890.
12. Das DK, Sheikh ZA, George SS, et al. Papillary thyroid carcinoma: evidence for intracytoplasmic formation of precursor substance for calcification and its release from well-preserved neoplastic cells [J]. Diagn Cytopathol, 2008; 36(11): 809-812.
13. 范自平, 喬智, 吳德敬. 甲狀腺癌診斷及復(fù)發(fā)因素分析 [J]. 中國(guó)普外基礎(chǔ)與臨床雜志, 2010； 17(1): 68-72.
14. Cotran RS, Kumar V, Collins T. Robbins pathologic basis of disease [M]. 6th ed. Noida, India: Harcourt Asia Pte, Ltd, 1999: 43-45, 1143-1144.
15. Hosoya T, Sakamoto A, Kasai N, et al. Nodal psammoma body in thyroid cancer as an indicator of cancer metastasis to the lymph node [J]. Gan No Rinsho, 1983; 29(11): 1336-1339.
16. Klinck GH, Winship T. Psammoma bodies and thyroid cancer [J]. Cancer, 1959; 12(4): 656-662.
17. 趙文雯, 王長(zhǎng)秋, 魯安懷， 等. 甲狀腺乳頭狀癌中砂粒體礦物學(xué)研究 [J]. 巖石礦物學(xué)雜志, 2009； 28(6): 623-628.
18. Bai Y, Zhou G, Nakamura M, et al. Survival impact of psammoma body, stromal calcification, and bone formation in papillary thyroid carcinoma [J]. Mod Pathol, 2009; 22(7): 887-894.
19. 唐波, 姜軍. RET原癌基因與分化性甲狀腺癌關(guān)系的研究進(jìn)展 [J]. 中國(guó)普外基礎(chǔ)與臨床雜志, 2004； 11(1): 89-91.
20. Adeniran AJ, Zhu Z, Gandhi M, et al. Correlation between genetic alterations and microscopic features, clinical manifestations, and prognostic characteristics of thyroid papillary carcinomas [J]. Am J Surg Pathol, 2006; 30(2): 216-222.
21. Smith JH. Psammoma bodies in cervical smears: sifting the grains of sand [J]. Cytopathology, 2007; 18(3): 140-142.
22. 楊若晨, 王長(zhǎng)秋, 魯安懷, 等. 腦膜瘤中砂粒體礦化研究 [J]. 地學(xué)前緣, 2008； 15(06): 44-53.
23. Han J, Daniel JC, Pappas GD. Expression of type Ⅵcollagen in psammoma bodies: immunofluorescence studies on two fresh human meningiomas [J]. Acta Cytol, 1996; 40(2): 177-181.
24. Kubota T, Yamashima T, Hasegawa M, et al. Formation of psammoma bodies in meningocytic whorls. Ultrastructural study and analysis of calcified material [J]. Acta Neuropathol, 1986; 70(3-4): 262-268.
25. 金曉明, 岡田英吉, 趙綱, 等. 人腦脈絡(luò)叢內(nèi)砂粒體的免疫組織化學(xué)研究 [J]. 臨床與實(shí)驗(yàn)病理學(xué)雜志, 1999； 15(1): 44-46.
26. Tunio GM, Hirota S, Nomura S, et al. Possible relation of osteopontin to development of psammoma bodies in human papillary thyroid cancer [J]. Arch Pathol Lab Med, 1998; 122(12): 1087-1090.
27. Miettinen M, Paetau A. Mapping of the keratin polypeptides in meningiomas of different types: an immunohistochemical analysis of 463 cases [J]. Hum Pathol, 2002; 33(6): 590-598.
28. Kumar V， Cotran RS, Robbins SL. Robbins basic pathology [M]. 7th ed. Philadelphia: Saunders, 2003: 657-717.
29. Rosai J. Rosai and Ackerma’s surgical pathology [M]. 9th ed. Edinburgh: Mosby, 2004: 1483-1761.
30. Tavassoli FA, Devilee P. Pathology and genetics of tumors of the breast and female genital organs [M]. lyon: IARC Press, 2003: 117-287.
31. Aure JC, Hoeg K, Kolstad P. Psammoma bodies in serous carcinoma of the ovary. A prognostic study [J]. Am J Obstet Gynecol, 1971; 109(1): 113-118.
32. Sorbe B, Frankendal B. Prognostic importance of psammoma bodies in adenocarcinomas of the ovaries [J]. Gynecol Oncol, 1982; 14(1): 6-14.
33. 王長(zhǎng)秋, 楊若晨, 魯安懷， 等. 人體卵巢癌中砂粒體礦化的礦物學(xué)研究 [J]. 巖石礦物學(xué)雜志, 2009； 28(6): 617-622.
34. Kiyozuka Y, Nakagawa H, Senzaki H, et al. Bone morphogenetic protein-2 and type Ⅳ collagen expression in psammoma body forming ovarian cancer [J]. Anticancer Res, 2001; 21(3B): 1723-1730.
35. Tsuchida T, Matsumoto M, Shirayama Y, et al. Observation of psammoma bodies in cultured meningiomas: analysis of three-dimensional structure using scanning and transmission electron microscopy [J]. Ultrastruct Pathol, 1996; 20(3): 241-247.
36. Das DK, Mallik MK, Haji BE, et al. Psammoma body and its precursors in papillary thyroid carcinoma: a study by fine-needle aspiration cytology [J]. Diagn Cytopathol, 2004; 31(6): 380-386.
  1. 1. Das DK. Psammoma body: a product of dystrophic calcification or of a biologically active process that aims at limiting the growth and spread of tumor? [J]. Diagn Cytopathol, 2009; 37(7): 534-541.
  2. 2. Gonzalez JE, Caldwell RG, Valaitis J. Calcium oxalate cry-stals in the breast. Pathology and significance [J]. Am J Surg Pathol, 1991; 15(6): 586-591.
  3. 3. Frappart L, Boudeulle M, Boumendil J, et al. Structure and composition of microcalcifications in benign and malignant lesions of the breast: study by light microscopy, transmission and scanning electron microscopy, microprobe analysis, and X-ray diffraction [J]. Hum Pathol, 1984; 15(9): 880-889.
  4. 4. Lanyi M. Microcalcifications in the breast-a blessing or a curse? A critical review [J]. Diagn Imaging Clin Med, 1985; 54(3-4): 126-145.
  5. 5. Fandos-Morera A, Prats-Esteve M, Tura-Soteras JM, et al. Breast tumors: composition of microcalcifications [J]. Radiology, 1988; 169(2): 325-327.
  6. 6. 官青, 吳毅. 砂粒體在甲狀腺癌研究中的進(jìn)展 [J]. 中國(guó)癌癥雜志， 2009； 19(8): 637-640.
  7. 7. Fadare O, Chacho MS, Parkash V. Psammoma bodies in cervicovaginal smears: significance and practical implications for diagnostic cytopathology [J]. Adv Anat Pathol, 2004; 11(5): 250-261.
  8. 8. Kubota T, Hirano A, Sato K, et al. Fine structure of psammoma bodies at the outer aspect of blood vessels in meningioma [J]. Acta Neuropathol, 1985; 66(2): 163-166.
  9. 9. 陳昊. 砂粒體在腫瘤中的形成與臨床意義 [J]. 河南腫瘤學(xué)雜志, 1999； 12(2): 148-149.
  10. 10. Johannessen JV, Sobrinho-Simes M. The origin and significance of thyroid psammoma bodies [J]. Lab Invest, 1980; 43(3): 287-296.
  11. 11. Cameron RI, McCluggage WG. Extensive psammomatous calcification of the uterus and cervix associated with a uterine serous carcinoma [J]. J Clin Pathol, 2004; 57(8): 888-890.
  12. 12. Das DK, Sheikh ZA, George SS, et al. Papillary thyroid carcinoma: evidence for intracytoplasmic formation of precursor substance for calcification and its release from well-preserved neoplastic cells [J]. Diagn Cytopathol, 2008; 36(11): 809-812.
  13. 13. 范自平, 喬智, 吳德敬. 甲狀腺癌診斷及復(fù)發(fā)因素分析 [J]. 中國(guó)普外基礎(chǔ)與臨床雜志, 2010； 17(1): 68-72.
  14. 14. Cotran RS, Kumar V, Collins T. Robbins pathologic basis of disease [M]. 6th ed. Noida, India: Harcourt Asia Pte, Ltd, 1999: 43-45, 1143-1144.
  15. 15. Hosoya T, Sakamoto A, Kasai N, et al. Nodal psammoma body in thyroid cancer as an indicator of cancer metastasis to the lymph node [J]. Gan No Rinsho, 1983; 29(11): 1336-1339.
  16. 16. Klinck GH, Winship T. Psammoma bodies and thyroid cancer [J]. Cancer, 1959; 12(4): 656-662.
  17. 17. 趙文雯, 王長(zhǎng)秋, 魯安懷， 等. 甲狀腺乳頭狀癌中砂粒體礦物學(xué)研究 [J]. 巖石礦物學(xué)雜志, 2009； 28(6): 623-628.
  18. 18. Bai Y, Zhou G, Nakamura M, et al. Survival impact of psammoma body, stromal calcification, and bone formation in papillary thyroid carcinoma [J]. Mod Pathol, 2009; 22(7): 887-894.
  19. 19. 唐波, 姜軍. RET原癌基因與分化性甲狀腺癌關(guān)系的研究進(jìn)展 [J]. 中國(guó)普外基礎(chǔ)與臨床雜志, 2004； 11(1): 89-91.
  20. 20. Adeniran AJ, Zhu Z, Gandhi M, et al. Correlation between genetic alterations and microscopic features, clinical manifestations, and prognostic characteristics of thyroid papillary carcinomas [J]. Am J Surg Pathol, 2006; 30(2): 216-222.
  21. 21. Smith JH. Psammoma bodies in cervical smears: sifting the grains of sand [J]. Cytopathology, 2007; 18(3): 140-142.
  22. 22. 楊若晨, 王長(zhǎng)秋, 魯安懷, 等. 腦膜瘤中砂粒體礦化研究 [J]. 地學(xué)前緣, 2008； 15(06): 44-53.
  23. 23. Han J, Daniel JC, Pappas GD. Expression of type Ⅵcollagen in psammoma bodies: immunofluorescence studies on two fresh human meningiomas [J]. Acta Cytol, 1996; 40(2): 177-181.
  24. 24. Kubota T, Yamashima T, Hasegawa M, et al. Formation of psammoma bodies in meningocytic whorls. Ultrastructural study and analysis of calcified material [J]. Acta Neuropathol, 1986; 70(3-4): 262-268.
  25. 25. 金曉明, 岡田英吉, 趙綱, 等. 人腦脈絡(luò)叢內(nèi)砂粒體的免疫組織化學(xué)研究 [J]. 臨床與實(shí)驗(yàn)病理學(xué)雜志, 1999； 15(1): 44-46.
  26. 26. Tunio GM, Hirota S, Nomura S, et al. Possible relation of osteopontin to development of psammoma bodies in human papillary thyroid cancer [J]. Arch Pathol Lab Med, 1998; 122(12): 1087-1090.
  27. 27. Miettinen M, Paetau A. Mapping of the keratin polypeptides in meningiomas of different types: an immunohistochemical analysis of 463 cases [J]. Hum Pathol, 2002; 33(6): 590-598.
  28. 28. Kumar V， Cotran RS, Robbins SL. Robbins basic pathology [M]. 7th ed. Philadelphia: Saunders, 2003: 657-717.
  29. 29. Rosai J. Rosai and Ackerma’s surgical pathology [M]. 9th ed. Edinburgh: Mosby, 2004: 1483-1761.
  30. 30. Tavassoli FA, Devilee P. Pathology and genetics of tumors of the breast and female genital organs [M]. lyon: IARC Press, 2003: 117-287.
  31. 31. Aure JC, Hoeg K, Kolstad P. Psammoma bodies in serous carcinoma of the ovary. A prognostic study [J]. Am J Obstet Gynecol, 1971; 109(1): 113-118.
  32. 32. Sorbe B, Frankendal B. Prognostic importance of psammoma bodies in adenocarcinomas of the ovaries [J]. Gynecol Oncol, 1982; 14(1): 6-14.
  33. 33. 王長(zhǎng)秋, 楊若晨, 魯安懷， 等. 人體卵巢癌中砂粒體礦化的礦物學(xué)研究 [J]. 巖石礦物學(xué)雜志, 2009； 28(6): 617-622.
  34. 34. Kiyozuka Y, Nakagawa H, Senzaki H, et al. Bone morphogenetic protein-2 and type Ⅳ collagen expression in psammoma body forming ovarian cancer [J]. Anticancer Res, 2001; 21(3B): 1723-1730.
  35. 35. Tsuchida T, Matsumoto M, Shirayama Y, et al. Observation of psammoma bodies in cultured meningiomas: analysis of three-dimensional structure using scanning and transmission electron microscopy [J]. Ultrastruct Pathol, 1996; 20(3): 241-247.
  36. 36. Das DK, Mallik MK, Haji BE, et al. Psammoma body and its precursors in papillary thyroid carcinoma: a study by fine-needle aspiration cytology [J]. Diagn Cytopathol, 2004; 31(6): 380-386.