• 昆明市第一人民醫(yī)院暨昆明醫(yī)學(xué)院附屬甘美醫(yī)院肝膽胰一科（昆明650011）;

目的  探討重組人生長(zhǎng)激素對(duì)腸道屏障功能的保護(hù)作用及其機(jī)理。方法  復(fù)習(xí)近年來(lái)國(guó)內(nèi)、外相關(guān)文獻(xiàn)并進(jìn)行綜述。 結(jié)果  重組人生長(zhǎng)激素能使腸黏膜細(xì)胞和免疫細(xì)胞增殖、防止細(xì)胞凋亡，對(duì)抗NO、細(xì)胞因子及內(nèi)毒素對(duì)屏障功能的損傷，增加腸道對(duì)谷氨酰胺的攝取和利用來(lái)維持腸黏膜的完整性和功能，以此維持腸道的屏障功能。結(jié)論  重組人生長(zhǎng)激素通過(guò)不同的途徑保護(hù)腸道屏障功能。

引用本文： 劉威,王欣博,童中勛,王治康,李立. 重組人生長(zhǎng)激素對(duì)腸道屏障功能的保護(hù)作用. 中國(guó)普外基礎(chǔ)與臨床雜志, 2009, 16(11): 948-951. doi: 復(fù)制

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2. Waters MJ, Hoang HN, Fairlie DP, et al. New insights into growth hormone action [J]． J Mol Endocrinol, 2006; 36(1): 1-7.
3. Redelman D, Welniak LA, Taub D, et al. Neuroendocrine hormones such as growth hormone and prolactin are integral members of the immunological cytokine network [J]．Cell Immunol, 2008; 252(1-2): 111-121.
4. 石毅， 趙玉沛， 廖泉, 等. 生長(zhǎng)激素對(duì)胰腺癌移植瘤細(xì)胞周期及宿主IGF-1與小腸黏膜形態(tài)的影響 [J]. 中國(guó)實(shí)用外科雜志, 2007; 27(10): 829-833.
5. 宋國(guó)棟, 王德昌, 賈軍, 等. 重組人生長(zhǎng)激素對(duì)燒傷大鼠腸粘膜結(jié)構(gòu)及細(xì)胞凋亡的影響 [J]. 中華燒傷雜志， 2002； 18(4): 207-209.
6. 秦爽, 賀育蘭, 楊靜， 等. 重組人生長(zhǎng)激素對(duì)內(nèi)毒素誘導(dǎo)人巨噬細(xì)胞產(chǎn)生TNF-α、IL-1β含量的影響 [J]. 中國(guó)感染控制雜志, 2008； 7(1)： 9-11.
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9. Scopa CD, Koureleas S, Tsamandas AC, et al. Beneficial effects of growth hormone and insulin-like growth factor Ⅰ on intestinal bacterial translocation, endotoxemia, and apoptosis in experimentally jaundiced rats [J]. J Am Coll Surg, 2000; 190(4): 423-431.
10. Yang ZW, Li JG, Mao XG, et al, Effects of recombinant human growth hormone on intestinal translocation of bacteria and endotoxin in rats with obstructive jaundice [J]. Hepatobiliary Pancreat Dis Int, 2005; 4(3): 445-449.
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14. Berni Canani R, Cirillo P, Mallardo G, et al . Growth hormone regulates intestinal ion transport through a modulation of the constitutive nitric oxide synthase-nitric oxide-cAMP pathway [J]. World J Gastroenterol, 2006; 12(29): 4710-4715.
15. Lobie PE, Breipohl W, Waters MJ. Growth hormone receptor expression in the rat gastrointestinal tract [J]. Endocrinology, 1990; 126(1): 299-306.
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21. Hiroki Mitsunakaa, Hiroaki Dobashia, Makoto Satoa.Gr-owth Hormone prevents fas-Induced apoptosis in lymphocytes through modulation of Bcl-2 and Caspase-3 [J]. Neuroimmunomodulation, 2001; 9（5）: 256-262.
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  1. 1. Smith JR, Benghuzzi H, Tucci M, et al．The effects of growth hormone and insulin-like growth factor on the proliferation rate and morphology of RAW 264.7 macrophages [J]. Biomed Sci Instrum, 2000; 36: 111-116.
  2. 2. Waters MJ, Hoang HN, Fairlie DP, et al. New insights into growth hormone action [J]． J Mol Endocrinol, 2006; 36(1): 1-7.
  3. 3. Redelman D, Welniak LA, Taub D, et al. Neuroendocrine hormones such as growth hormone and prolactin are integral members of the immunological cytokine network [J]．Cell Immunol, 2008; 252(1-2): 111-121.
  4. 4. 石毅， 趙玉沛， 廖泉, 等. 生長(zhǎng)激素對(duì)胰腺癌移植瘤細(xì)胞周期及宿主IGF-1與小腸黏膜形態(tài)的影響 [J]. 中國(guó)實(shí)用外科雜志, 2007; 27(10): 829-833.
  5. 5. 宋國(guó)棟, 王德昌, 賈軍, 等. 重組人生長(zhǎng)激素對(duì)燒傷大鼠腸粘膜結(jié)構(gòu)及細(xì)胞凋亡的影響 [J]. 中華燒傷雜志， 2002； 18(4): 207-209.
  6. 6. 秦爽, 賀育蘭, 楊靜， 等. 重組人生長(zhǎng)激素對(duì)內(nèi)毒素誘導(dǎo)人巨噬細(xì)胞產(chǎn)生TNF-α、IL-1β含量的影響 [J]. 中國(guó)感染控制雜志, 2008； 7(1)： 9-11.
  7. 7. 郭光華， 蔡晨， 李國(guó)輝. 腸內(nèi)免疫營(yíng)養(yǎng)聯(lián)合重組人生長(zhǎng)激素對(duì)燙傷大鼠的治療作用 [J]. 中國(guó)危重病急救醫(yī)學(xué), 2006； 18(1)： 42-45.
  8. 8. 王興鵬， 王冰嫻， 吳建新， 等. 生長(zhǎng)激素對(duì)實(shí)驗(yàn)性急性壞死性胰腺炎腸道細(xì)菌移居的影響 [J]. 中華消化雜志, 2000； 20(3)： 171-174.
  9. 9. Scopa CD, Koureleas S, Tsamandas AC, et al. Beneficial effects of growth hormone and insulin-like growth factor Ⅰ on intestinal bacterial translocation, endotoxemia, and apoptosis in experimentally jaundiced rats [J]. J Am Coll Surg, 2000; 190(4): 423-431.
  10. 10. Yang ZW, Li JG, Mao XG, et al, Effects of recombinant human growth hormone on intestinal translocation of bacteria and endotoxin in rats with obstructive jaundice [J]. Hepatobiliary Pancreat Dis Int, 2005; 4(3): 445-449.
  11. 11. 黃英， 王樹(shù)人， 應(yīng)明英, 等. 重組人生長(zhǎng)激素對(duì)敗血癥大鼠的實(shí)驗(yàn)治療 [J]. 中國(guó)病理生理雜志, 2003; 19(9)： 1253-1256.
  12. 12. 周彤, 伍曉汀, 羅婷, 等. 生長(zhǎng)激素對(duì)脂多糖刺激大鼠腹腔巨噬細(xì)胞NO產(chǎn)生及iNOS mRNA表達(dá)的影響及意義 [J]. 華西醫(yī)學(xué), 2006； 21(3): 535-537.
  13. 13. 徐一洲, 黃煌, 曹玥, 等. 重組人生長(zhǎng)激素對(duì)敗血癥大鼠炎癥調(diào)控網(wǎng)絡(luò)的影響 [J]. 華西藥學(xué)雜志, 2007; 22(2)： 142-144.
  14. 14. Berni Canani R, Cirillo P, Mallardo G, et al . Growth hormone regulates intestinal ion transport through a modulation of the constitutive nitric oxide synthase-nitric oxide-cAMP pathway [J]. World J Gastroenterol, 2006; 12(29): 4710-4715.
  15. 15. Lobie PE, Breipohl W, Waters MJ. Growth hormone receptor expression in the rat gastrointestinal tract [J]. Endocrinology, 1990; 126(1): 299-306.
  16. 16. Jeay S, Sonenshein GE, Postel-Vinay MC, et al. Growth hormone can act as a cytokine controlling survival and proliferation of immune cells: new insights into signaling pathways [J]. Mol Cell Endocrinol, 2002; 188(1-2): 1-7.
  17. 17. 馬少林, 王曉紅, 楊曉軍, 等. 創(chuàng)傷-失血性休克與細(xì)胞免疫功能的臨床研究 [J]. 寧夏醫(yī)學(xué)雜志, 2007; 29(7): 605-606.
  18. 18. 于勇, 盛志勇, 田惠民, 等. 大鼠燙傷后腸道免疫屏障損傷的實(shí)驗(yàn)研究 [J]. 中華整形燒傷外科雜志, 1996; 12(2): 86-89.
  19. 19. 劉海波, 孫少川, 鄭春寧, 等. 重組人生長(zhǎng)激素對(duì)腸缺血再灌注大鼠腸壁IgA漿細(xì)胞凋亡及P53基因表達(dá)影響的實(shí)驗(yàn)研究 [J]. 中國(guó)現(xiàn)代普通外科進(jìn)展, 2006； 9(6)： 337-339.
  20. 20. 孫少川, 鄭春寧, 劉國(guó)勤， 等. 重組人生長(zhǎng)激素對(duì)大鼠腸道缺血再灌注后腸壁組織T淋巴細(xì)胞亞群和漿細(xì)胞凋亡的影響 [J]. 中華實(shí)驗(yàn)外科雜志, 2006; 23(5): 605-606.
  21. 21. Hiroki Mitsunakaa, Hiroaki Dobashia, Makoto Satoa.Gr-owth Hormone prevents fas-Induced apoptosis in lymphocytes through modulation of Bcl-2 and Caspase-3 [J]. Neuroimmunomodulation, 2001; 9（5）: 256-262.
  22. 22. 王輝, 鄧潔英, 史軼蘩. 生長(zhǎng)激素調(diào)節(jié)T淋巴細(xì)胞的功能 [J]. 中國(guó)免疫學(xué)雜志, 2000; 16(9): 480-484.
  23. 23. Matarese LE, Abu-Elmagd K. Can growth hormone and glutamine reduce parenteral nutrition requirements in patients with short-bowel syndrome? [J]．Nat Clin Pract Gastroenterol Hepatol, 2006; 3(4): 194-195.
  24. 24. Shulman DI. Gastrointestinal effects of growth hormone [J]. Endocrine, 2000; 12(2): 147-152.
  25. 25. Byrne TA, Wilmore DW, Iyer K. Growth hormone, glutamine, and an optimal diet reduces parenteral nutrition in patients with short bowel syndrome: a prospective, randomized, placebo-controlled, double-blind clinical trial [J]. Ann Surg, 2005; 242(5): 655-661.
  26. 26. Ray EC, Avissar NE, Salloum R, et al. Growth hormone and epidermal growth factor upregulate specific sodium-dependent glutamine uptake systems in human intestinal C2BBe1 cells [J]. J Nutr, 2005; 135(1): 14-18.
  27. 27. Jeay S, Sonenshein GE, Kelly PA, et al. Growth hormone exerts antiapoptotic and proliferative effects through two different pathways involving nuclear factor-kappaB and phosphatidylinositol 3-kinase [J]. Endocrinology, 2001; 142(1): 147-156.
  28. 28. Jeay S, Sonenshein GE, Postel-Vinay MC, et al. Growth hormone prevents apoptosis through activation of nuclear factor-kappaB in interleukin-3-dependent Ba/F3 cell line [J]. Mol Endocrinol, 2000; 14(5): 650-661.
  29. 29. Darmaun D, Hayes V, Schaeffer D, et al. Effects of glutamine and recombinant human growth hormone on protein metabolism in prepubertal children with cystic fibrosis [J]. J Clin Endocrinol Metab, 2004; 89(3): 1146-1152.
  30. 30. Bogazzi F, Russo D, Locci MT. Apoptosis is reduced in the colonic mucosa of patients with acromegaly [J]. Clin Endocrinol (Oxf), 2005; 63(6): 683-688.
  31. 31. Baixeras E, Jeay S, Kelly PA, et al. The proliferative and antiapoptotic actions of growth hormone and insulin-like growth factor-1 are mediated through distinct signaling pathways in the Pro-B Ba/F3 cell line [J]. Endocrinology, 2001; 142(7): 2968-2977.
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