• 1.哈爾濱醫(yī)科大學(xué)第一臨床醫(yī)學(xué)院ICU科（哈爾濱150001）;;
  • 2.哈爾濱醫(yī)科大學(xué)第一臨床醫(yī)學(xué)院普外科（哈爾濱150001）;

目的 探討氣體信號(hào)分子硫化氫（H2S）與疾病之間的關(guān)系。
方法 查閱有關(guān)H2S與疾病的文獻(xiàn)并進(jìn)行分析。
結(jié)果 H2S被認(rèn)為是一種新型氣體信號(hào)傳遞分子，可以作用于血管平滑?。薃TP通道，通過對(duì)血管的擴(kuò)張作用來調(diào)節(jié)血壓。H2S在肺動(dòng)脈高壓、缺血再灌注損傷、神經(jīng)傳遞、凋亡及炎癥反應(yīng)中發(fā)揮了重要的作用。
結(jié)論 H2S作為第3種氣體信號(hào)分子，在哺乳動(dòng)物中發(fā)揮了重要的生理和病理作用，為新藥開發(fā)及許多疾病的治療提供新的手段。

引用本文： 康凱 ,姜洪池. ３Ｈ氣體信號(hào)分子硫化氫與疾病. 中國普外基礎(chǔ)與臨床雜志, 2009, 16(2): 170-173. doi: 復(fù)制

1. 10 楊廣東， 王睿. 硫化氫與細(xì)胞的增殖和凋亡[J]. 生物學(xué)報(bào),2007; 59(2)： 133 11Bhatia M. Hydrogen sulfide as a vasodilator[J].IUBMB Life， 2005; 57(9)： 603.
2. Kimura H. Hydrogen sulfide as a neuromodulator[J].Mol Neurobiol, 2002; 26(1)：13.
3. Zhao W, Zhang J, Lu Y, et al. The vasorelaxant effect of H2S as a novel endogenous gaseous K(ATP) channel opener[J].EMBO J, 2001； 20(21)： 6008.
4. Geng B, Yang J, Qi Y, et al. H2S generated by heart in rat and its effects on cardiac function[J]. Biochem Biophys Res Commun, 2004; 313（2）：362.
5. Zhao W, Wang R.H2S-induced vasorelaxation and underlying cellular and molecular mechanisms[J]. Am J Physiol Heart Circ Physiol, 2002; 283(2)：H474.
6. Stipanuk MH, Beck PW. Characterization of the enzymic capacity for cysteine desulphhydration in liver and kidney of the rat[J].Biochem J, 1982； 206(2)： 267.
7. Hosoki R，　Matsuki N, 　Kimura H. The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide[J].Biochem Biophys Res Commun, 1997; 237(3)： 527.
8. Zhao W, Ndisang JF, Wang R. Modulation of endogenous production of H2S in rat tissues[J].Can J Physiol Pharmacol, 2003; 81(9)： 848.
9. owicka E, Betowski J. Hydrogen sulfide (H2S)-the third gas of interest for pharmacologists[J].Pharmacol Rep, 2007;59(1)： 4.
10. Yang G，　Sun X，　Wang R. Hydrogen sulfide-induced apoptosis of human aorta smooth muscle cells via the activation of mitogen-activated protein kinases and caspase-3[J].FASEB J， 2004; 18(14)： 1782.
11. 張清友， 杜軍保， 張春雨， 等.低氧性肺動(dòng)脈高壓形成中氣體信號(hào)分子硫化氫對(duì)一氧化碳／血紅素加氧酶途徑的影響[J]. 中華結(jié)核和呼吸雜志， 2004； 27（10）： 659.
12. 陳曉波, 杜軍保, 張春雨， 等. 新型氣體信號(hào)分子硫化氫對(duì)低氧大鼠肺動(dòng)脈平滑肌細(xì)胞凋亡的影響[J].北京大學(xué)學(xué)報(bào)(醫(yī)學(xué)版),2004； 36(4)： 341.
13. 閻輝， 杜軍保， 唐朝樞.硫化氫對(duì)自發(fā)性高血壓大鼠胸主動(dòng)脈舒張反應(yīng)的影響[J].中國藥理學(xué)通報(bào)， 2003； 19（6）： 633.
14. Ali MY, Ping CY, Mok YY， et al. Regulation of vascular nitric oxide in vitro and in vivo; a new role for endogenous hydrogen sulphide?[J]. Br J Pharmacol,2006； 149（6）：625.
15. Webb GD, Lim LH, Oh VM， et al.Contractile and vasorelaxant effects of hydrogen sulfide and its biosynthesis in the human internal mammary artery[J]. J Pharmacol Exp Ther,2008； 324(2)： 876.
16. Elrod JW, Calvert JW, Morrison J, et al. Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function [J]. Proc Natl Acad Sci U S A， 2007; 104(39)： 15560.
17. Chen YH， Yao WZ， Geng B， et al. Endogenous hydrogen sulfide in patients with COPD [J].Chest,2005; 128(5)：3205.
18. 伍蕊, 姚婉貞,陳亞紅,等. 硫化氫在大鼠急性支氣管哮喘模型中的變化及意義 [J].中華結(jié)核和呼吸雜志, 2007;30(7)： 522.
19. Eto K, Ogasawara M, Umemura K, et al. Hydrogen sulfide is produced in response to neuronal excitation [J]. J Neurosci, 2002; 22(9)：3386.
20. Lee SW, Hu YS, Hu LF, et al. Hydrogen sulphide regulates calcium homeostasis in microglial cells [J]. Glia, 2006; 54(2)：116.
21. García-Bereguiaín MA, Samhan-Arias AK, Martín-Romero FJ, et al. Hydrogen sulfide raises cytosolic calcium in neurons through activation of L-type Ca2+ channels[J]. Antioxid Redox Signal,2008； 10(1)：31.
22. Eto K, Asada T, Arima K, et al. Brain hydrogen sulfide is severely decreased in Alzheimer’s disease [J].Biochem Biophys Res Commun, 2002； 293（5）： 1485.
23. Zhi L, Ang AD, Zhang H, et al. Hydrogen sulfide induces the synthesis of proinflammatory cytokines in human monocyte cell line U937 via the ERK-NF-kappaB pathway [J]. J Leukoc Biol,2007； 81(5)：1322.
24. 陳曉波,　杜軍保, 耿彬， 等.感染性和內(nèi)毒素性休克大鼠動(dòng)脈組織中硫化氫的變化 [J].基礎(chǔ)醫(yī)學(xué)與臨床, 2003； 23(4)： 384.
25. Zhang H, Zhi L, Moochhala SM， et al. Endogenous hydrogen sulfide regulates leukocyte trafficking in cecal ligation and puncture-induced sepsis [J].J Leukoc Biol,2007； 82(4)：894.
26. Zhang H, Hegde A, Ng SW, et al. Hydrogen sulfide up-regulates substance P in polymicrobial sepsis-associated lung injury [J].J Immunol,2007； 179(6)：4153.
27. Bhatia M, Wong FL, Fu D, et al. Role of hydrogen sulfide in acute pancreatitis and associated lung injury[J].FASEB J,2005； 19(6)： 623.
28. Tamizhselvi R,Moore PK,Bhatia M.Hydrogen sulfide acts as a mediator of inflammation in acute pancreatitis: in vitro studies using isolated mouse pancreatic acinar cells[J].J Cell Mol Med, 2007;11(2)：315.
29. Collin M, Anuar FB, Murch O, et al. Inhibition of endogenous hydrogen sulfide formation reduces the organ injury caused by endotoxemia[J].Br J Pharmacol, 2005； 146（4）：498.
30. Bhatia M， Sidhapuriwala J, Moochhala SM, et al. Hydrogen sulphide is a mediator of carrageenan-induced hindpaw oedema in the rat [J].Br J Pharmacol, 2005； 145（2）： 141.
31. 戴鴻雁, 凌亦凌, 黃新莉, 等.硫化氫在內(nèi)毒素血癥大鼠動(dòng)脈舒張反應(yīng)性改變中的作用及其與一氧化氮的關(guān)系 [J]. 河北醫(yī)科大學(xué)學(xué)報(bào)， 2004； 25(6)： 355.
32. Distrutti E, Sediari L, Mencarelli A, et al. Evidence that hydrogen sulfide exerts antinociceptive effects in the gastrointestinal tract by activating KATP channels [J]. J Pharmacol Exp Ther, 2006； 16(1)：325.
33. Lou LX,Geng B,Du JB， et al. Hydrogen sulphide-induced hypothermia attenuates stress-related ulceration in rats [J].Clin Exp Pharmacol Physiol, 2008； 35(2)：223.
34. Fiorucci S,Santucci L,Distrutti E.NSAIDs, coxibs, CINOD and H2S-releasing NSAIDs: what lies beyond the horizon [J]. Dig Liver Dis,2007； 39(12)：1043.
35. Streng T,Axelsson HE,Hedlund P， et al. Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder [J].Eur Urol,2008； 53(2)： 391.
  1. 1. 10 楊廣東， 王睿. 硫化氫與細(xì)胞的增殖和凋亡[J]. 生物學(xué)報(bào),2007; 59(2)： 133 11Bhatia M. Hydrogen sulfide as a vasodilator[J].IUBMB Life， 2005; 57(9)： 603.
  2. 2. Kimura H. Hydrogen sulfide as a neuromodulator[J].Mol Neurobiol, 2002; 26(1)：13.
  3. 3. Zhao W, Zhang J, Lu Y, et al. The vasorelaxant effect of H2S as a novel endogenous gaseous K(ATP) channel opener[J].EMBO J, 2001； 20(21)： 6008.
  4. 4. Geng B, Yang J, Qi Y, et al. H2S generated by heart in rat and its effects on cardiac function[J]. Biochem Biophys Res Commun, 2004; 313（2）：362.
  5. 5. Zhao W, Wang R.H2S-induced vasorelaxation and underlying cellular and molecular mechanisms[J]. Am J Physiol Heart Circ Physiol, 2002; 283(2)：H474.
  6. 6. Stipanuk MH, Beck PW. Characterization of the enzymic capacity for cysteine desulphhydration in liver and kidney of the rat[J].Biochem J, 1982； 206(2)： 267.
  7. 7. Hosoki R，　Matsuki N, 　Kimura H. The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide[J].Biochem Biophys Res Commun, 1997; 237(3)： 527.
  8. 8. Zhao W, Ndisang JF, Wang R. Modulation of endogenous production of H2S in rat tissues[J].Can J Physiol Pharmacol, 2003; 81(9)： 848.
  9. 9. owicka E, Betowski J. Hydrogen sulfide (H2S)-the third gas of interest for pharmacologists[J].Pharmacol Rep, 2007;59(1)： 4.
  10. 10. Yang G，　Sun X，　Wang R. Hydrogen sulfide-induced apoptosis of human aorta smooth muscle cells via the activation of mitogen-activated protein kinases and caspase-3[J].FASEB J， 2004; 18(14)： 1782.
  11. 11. 張清友， 杜軍保， 張春雨， 等.低氧性肺動(dòng)脈高壓形成中氣體信號(hào)分子硫化氫對(duì)一氧化碳／血紅素加氧酶途徑的影響[J]. 中華結(jié)核和呼吸雜志， 2004； 27（10）： 659.
  12. 12. 陳曉波, 杜軍保, 張春雨， 等. 新型氣體信號(hào)分子硫化氫對(duì)低氧大鼠肺動(dòng)脈平滑肌細(xì)胞凋亡的影響[J].北京大學(xué)學(xué)報(bào)(醫(yī)學(xué)版),2004； 36(4)： 341.
  13. 13. 閻輝， 杜軍保， 唐朝樞.硫化氫對(duì)自發(fā)性高血壓大鼠胸主動(dòng)脈舒張反應(yīng)的影響[J].中國藥理學(xué)通報(bào)， 2003； 19（6）： 633.
  14. 14. Ali MY, Ping CY, Mok YY， et al. Regulation of vascular nitric oxide in vitro and in vivo; a new role for endogenous hydrogen sulphide?[J]. Br J Pharmacol,2006； 149（6）：625.
  15. 15. Webb GD, Lim LH, Oh VM， et al.Contractile and vasorelaxant effects of hydrogen sulfide and its biosynthesis in the human internal mammary artery[J]. J Pharmacol Exp Ther,2008； 324(2)： 876.
  16. 16. Elrod JW, Calvert JW, Morrison J, et al. Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function [J]. Proc Natl Acad Sci U S A， 2007; 104(39)： 15560.
  17. 17. Chen YH， Yao WZ， Geng B， et al. Endogenous hydrogen sulfide in patients with COPD [J].Chest,2005; 128(5)：3205.
  18. 18. 伍蕊, 姚婉貞,陳亞紅,等. 硫化氫在大鼠急性支氣管哮喘模型中的變化及意義 [J].中華結(jié)核和呼吸雜志, 2007;30(7)： 522.
  19. 19. Eto K, Ogasawara M, Umemura K, et al. Hydrogen sulfide is produced in response to neuronal excitation [J]. J Neurosci, 2002; 22(9)：3386.
  20. 20. Lee SW, Hu YS, Hu LF, et al. Hydrogen sulphide regulates calcium homeostasis in microglial cells [J]. Glia, 2006; 54(2)：116.
  21. 21. García-Bereguiaín MA, Samhan-Arias AK, Martín-Romero FJ, et al. Hydrogen sulfide raises cytosolic calcium in neurons through activation of L-type Ca2+ channels[J]. Antioxid Redox Signal,2008； 10(1)：31.
  22. 22. Eto K, Asada T, Arima K, et al. Brain hydrogen sulfide is severely decreased in Alzheimer’s disease [J].Biochem Biophys Res Commun, 2002； 293（5）： 1485.
  23. 23. Zhi L, Ang AD, Zhang H, et al. Hydrogen sulfide induces the synthesis of proinflammatory cytokines in human monocyte cell line U937 via the ERK-NF-kappaB pathway [J]. J Leukoc Biol,2007； 81(5)：1322.
  24. 24. 陳曉波,　杜軍保, 耿彬， 等.感染性和內(nèi)毒素性休克大鼠動(dòng)脈組織中硫化氫的變化 [J].基礎(chǔ)醫(yī)學(xué)與臨床, 2003； 23(4)： 384.
  25. 25. Zhang H, Zhi L, Moochhala SM， et al. Endogenous hydrogen sulfide regulates leukocyte trafficking in cecal ligation and puncture-induced sepsis [J].J Leukoc Biol,2007； 82(4)：894.
  26. 26. Zhang H, Hegde A, Ng SW, et al. Hydrogen sulfide up-regulates substance P in polymicrobial sepsis-associated lung injury [J].J Immunol,2007； 179(6)：4153.
  27. 27. Bhatia M, Wong FL, Fu D, et al. Role of hydrogen sulfide in acute pancreatitis and associated lung injury[J].FASEB J,2005； 19(6)： 623.
  28. 28. Tamizhselvi R,Moore PK,Bhatia M.Hydrogen sulfide acts as a mediator of inflammation in acute pancreatitis: in vitro studies using isolated mouse pancreatic acinar cells[J].J Cell Mol Med, 2007;11(2)：315.
  29. 29. Collin M, Anuar FB, Murch O, et al. Inhibition of endogenous hydrogen sulfide formation reduces the organ injury caused by endotoxemia[J].Br J Pharmacol, 2005； 146（4）：498.
  30. 30. Bhatia M， Sidhapuriwala J, Moochhala SM, et al. Hydrogen sulphide is a mediator of carrageenan-induced hindpaw oedema in the rat [J].Br J Pharmacol, 2005； 145（2）： 141.
  31. 31. 戴鴻雁, 凌亦凌, 黃新莉, 等.硫化氫在內(nèi)毒素血癥大鼠動(dòng)脈舒張反應(yīng)性改變中的作用及其與一氧化氮的關(guān)系 [J]. 河北醫(yī)科大學(xué)學(xué)報(bào)， 2004； 25(6)： 355.
  32. 32. Distrutti E, Sediari L, Mencarelli A, et al. Evidence that hydrogen sulfide exerts antinociceptive effects in the gastrointestinal tract by activating KATP channels [J]. J Pharmacol Exp Ther, 2006； 16(1)：325.
  33. 33. Lou LX,Geng B,Du JB， et al. Hydrogen sulphide-induced hypothermia attenuates stress-related ulceration in rats [J].Clin Exp Pharmacol Physiol, 2008； 35(2)：223.
  34. 34. Fiorucci S,Santucci L,Distrutti E.NSAIDs, coxibs, CINOD and H2S-releasing NSAIDs: what lies beyond the horizon [J]. Dig Liver Dis,2007； 39(12)：1043.
  35. 35. Streng T,Axelsson HE,Hedlund P， et al. Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder [J].Eur Urol,2008； 53(2)： 391.