• 首都醫(yī)科大學宣武醫(yī)院普外科(北京 100053);

目的  分析近20年來單中心細菌性肝膿腫治療方法和療效的變化。方法  回顧性分析我科1989年1月至2008年12月期間收治的198例細菌性肝膿腫患者的臨床資料,按入院時間分為1989~1995年組、1996~2002年組及2003~2008年組,比較各組患者的性別、年齡、合并癥、膿腫部位、膿腫個數(shù)、膿腫大小、治療方法、住院時間、并發(fā)癥發(fā)生率及死亡率。結(jié)果  3組患者分別有54、69及75例; 3組患者在性別、年齡、有無糖尿病、膿腫部位、膿腫個數(shù)及膿腫大小方面差異均無統(tǒng)計學意義(P gt;0.05)。1989~1995年組行開腹手術(shù)35例(64.8%)、腹腔鏡手術(shù)8例(14.8%)、經(jīng)皮穿刺抽吸/置管引流11例(20.4%); 1996~2002年組行單純抗生素治療2例(2.9%)、開腹手術(shù)15例(21.8%)、腹腔鏡手術(shù)21例(30.4%)、經(jīng)皮穿刺抽吸/置管引流31例(44.9%); 2003~2008年組行單純抗生素治療3例(4.0%)、開腹手術(shù)5例(6.7%)、腹腔鏡手術(shù)13例(17.3%)、經(jīng)皮穿刺抽吸/置管引流54例(72.0%)。3組患者的治療方法構(gòu)成比差異有統(tǒng)計學意義(P<0.05)。3組患者住院時間分別為(18.5±12.2) d、(16.4±12.8) d 及(20.1±14.6) d,術(shù)后并發(fā)癥發(fā)生率分別為9.3%(5/54)、4.3%(3/69)及4.0%(3/75),死亡率分別為3.7%(2/54)、1.4%(1/69)及1.3%(1/75),差異均無統(tǒng)計學意義(P gt;0.05)。結(jié)論  隨著外科技術(shù)的進步,有效的抗生素治療、經(jīng)皮置管引流或細針抽吸已成為細菌性肝膿腫的主要治療方法,腹腔鏡和開腹手術(shù)是必要的補充。

引用本文: 劉強,王亞軍,劉家峰,李非,孫家邦,王悅?cè)A. 細菌性肝膿腫治療的單中心20年回顧分析. 中國普外基礎(chǔ)與臨床雜志, 2009, 16(5): 389-392. doi: 復(fù)制

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3. ]Ferraioli G, Garlaschelli A, Zanaboni D, et al. Percutaneous and surgical treatment of pyogenic liver abscesses: observation over a 21-year period in 148 patients [J]. Dig Liver Dis, 2008; 40(8): 690-696.
4. Tarcoveanu E, Vlad N, Moldovanu R, et al. Pyogenic liver abscesses [J]. Chirurgia (Bucur), 2008; 103(4): 417-427.[3]Ochsner A, DeBakey M, Murray S. Pyogenic abscess of the liver: An analysis of forty-seven cases with review of the literature [J]. Am J Surg, 1938; 40(3): 292-319.[4]Huang CJ, Pitt HA, Lipsett PA, et al. Pyogenic hepatic abscess. Changing trends over 42 years [J]. Ann Surg, 1996; 223(5): 600-609.[5]Lazarenko VA, Okhotnikov OI, Chukhraev AM, et al. Minimally invasive surgery of liver abscesses [J]. Vestn Khir Im I I Grek, 2003; 162(2): 88-91.[6]常自健, 馬志偉, 王雁霞, 等. B超引導(dǎo)下穿刺引流腹腔深部膿腫36例體會 [J]. 中國普外基礎(chǔ)與臨床雜志, 2002; 9(4): 231.[7]彭建平, 何生. 糖尿病合并肝膿腫的外科治療(附22例報告) [J]. 中國普外基礎(chǔ)與臨床雜志, 2005; 12(2): 173-174.[8]Alvarez Pérez JA, González JJ, Baldonedo RF, et al. Clinical course, treatment, and multivariate analysis of risk factors for pyogenic liver abscess [J]. Am J Surg, 2001; 181(2): 177-186.[9]Wang W, Lee WJ, Wei PL, et al. Laparoscopic drainage of pyogenic liver abscesses [J]. Surg Today, 2004; 34(4): 323-325.
5. Vogl TJ, Estifan F. Pyogenic liver abscess: interventional versus surgical therapy: technique, results and indications [J]. Rofo, 2001; 173(7): 663-667.
6. Okano H, Shiraki K, Inoue H, et al.Clinicopathological analysis of liver abscess in Japan [J]. Int J Mol Med, 2002; 10(5): 627-630.
  1. 1. [10]Rajak CL, Gupta S, Jain S, et al. Percutaneous treatment of liver abscesses: needle aspiration versus catheter drainage [J]. AJR Am J Roentgenol, 1998; 170(4): 1035-1039.
  2. 2. [13]Petri A, Hhn J, Hdi Z, et al. Pyogenic liver abscess—20 years’ experience. Comparison of results of treatment in two periods [J]. Langenbecks Arch Surg, 2002; 387(1): 27-31.
  3. 3. ]Ferraioli G, Garlaschelli A, Zanaboni D, et al. Percutaneous and surgical treatment of pyogenic liver abscesses: observation over a 21-year period in 148 patients [J]. Dig Liver Dis, 2008; 40(8): 690-696.
  4. 4. Tarcoveanu E, Vlad N, Moldovanu R, et al. Pyogenic liver abscesses [J]. Chirurgia (Bucur), 2008; 103(4): 417-427.[3]Ochsner A, DeBakey M, Murray S. Pyogenic abscess of the liver: An analysis of forty-seven cases with review of the literature [J]. Am J Surg, 1938; 40(3): 292-319.[4]Huang CJ, Pitt HA, Lipsett PA, et al. Pyogenic hepatic abscess. Changing trends over 42 years [J]. Ann Surg, 1996; 223(5): 600-609.[5]Lazarenko VA, Okhotnikov OI, Chukhraev AM, et al. Minimally invasive surgery of liver abscesses [J]. Vestn Khir Im I I Grek, 2003; 162(2): 88-91.[6]常自健, 馬志偉, 王雁霞, 等. B超引導(dǎo)下穿刺引流腹腔深部膿腫36例體會 [J]. 中國普外基礎(chǔ)與臨床雜志, 2002; 9(4): 231.[7]彭建平, 何生. 糖尿病合并肝膿腫的外科治療(附22例報告) [J]. 中國普外基礎(chǔ)與臨床雜志, 2005; 12(2): 173-174.[8]Alvarez Pérez JA, González JJ, Baldonedo RF, et al. Clinical course, treatment, and multivariate analysis of risk factors for pyogenic liver abscess [J]. Am J Surg, 2001; 181(2): 177-186.[9]Wang W, Lee WJ, Wei PL, et al. Laparoscopic drainage of pyogenic liver abscesses [J]. Surg Today, 2004; 34(4): 323-325.
  5. 5. Vogl TJ, Estifan F. Pyogenic liver abscess: interventional versus surgical therapy: technique, results and indications [J]. Rofo, 2001; 173(7): 663-667.
  6. 6. Okano H, Shiraki K, Inoue H, et al.Clinicopathological analysis of liver abscess in Japan [J]. Int J Mol Med, 2002; 10(5): 627-630.