目的 研究環(huán)氧合酶-2（cyclooxygenase-2，Cox-2）及血管生成素-2 (angiopoietin-2,Ang-2)在大腸癌組織、癌旁組織及正常大腸組織中的表達(dá)及其與大腸癌臨床病理特征之間的關(guān)系。方法 采用免疫組化SP法檢測45例大腸癌組織、45例癌旁組織及15例正常大腸組織中Cox-2和Ang-2的表達(dá)情況。 結(jié)果 大腸癌組織中的Cox-2和 Ang-2的表達(dá)陽性率(80.0%,66.7%)均分別高于癌旁組織(35.6%,11.1%)及正常大腸組織(0,0)，P均＜0.01。在大腸癌組織中Cox-2和Ang-2蛋白表達(dá)與淋巴結(jié)轉(zhuǎn)移及Dukes分期有關(guān)(P＜0.05),且二者的表達(dá)具有相關(guān)性(P＜0.01)。結(jié)論 Cox-2和Ang-2在大腸癌發(fā)生、發(fā)展中起重要作用，二者在表達(dá)上密切相關(guān)。
引用本文： 張寧,陶凱雄,王國斌,田元. 環(huán)氧合酶-2及血管生成素-2在大腸癌中的表達(dá)及臨床意義△. 中國普外基礎(chǔ)與臨床雜志, 2006, 13(5): 564-567. doi: 復(fù)制
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- 1. Ozdemir E, Kakehi Y, Okuno H, et al. Role of matrix metalloproteinase-9 in the basement membrane destruction of superficial urothelial carcinomas [J]. J Urol, 1999; 161(4)∶1359.
- 2. Oshima M, Dinchuk JE, Kargman SL, et al. Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2) [J]. Cell， 1996; 87(5)∶803.
- 3. Seno H, Oshima M, Ishikawa TO, et al. Cyclooxygenase 2-and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps [J]. Cancer Res, 2002; 62(2)∶506.
- 4. Yancopoulos GD, Davis S, Gale NW, et al. Vascular-specific growth factors and blood vessel formation [J]. Nature, 2000; 407(6801)∶242.
- 5. Smith TJ. Cyclooxygenases as the principal targets for the actions of NSAIDs [J]. Rheum Dis Clin North Am, 1998; 24(3)∶501.
- 6. Sinicrope FA, Gill S. Role of cyclooxygenase-2 in colorectal cancer [J]. Cancer Metastasis Rev, 2004; 23(1-2)∶63.
- 7. Ahmad SA, Liu W, Jung YD, et al. Differential expression of angiopoietin-1 and angiopoietin-2 in colon carcinoma. A possible mechanism for the initiation of angiogenesis [J]. Cancer, 2001; 92(5)∶1138.
- 8. Tsujii M, Kawano S, Tsuji S, et al.Cyclooxygenase regulates angiogenesis induced by colon cancer cells [J]. Cell, 1998; 93(5)∶705.
- 9. Williams CS, Tsujii M, Reese J, et al.Host cyclooxygenase-2 modulates carcinoma growth [J]. J Clin Invest, 2000; 105(11)∶1511.
- 10. Papapetropoulos A, Fulton D, Mahboubi K, et al. Angiopoietin-1 inhibits endothelial cell apoptosis via the Akt/survivin pathway [J]. J Biol Chem, 2000; 275(13)∶9102.
- 11. Witzenbichler B, Maisonpierre PC, Jones P, et al. Chemotactic properties of angiopoietin-1 and-2, ligands for the endothelial-specific receptor tyrosine kinase Tie2 [J]. J Biol Chem， 1998; 273(29)∶18514.
- 12. Thurston G, Suri C, Smith K, et al. Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1 [J]. Science， 1999; 286(5449)∶2511.