目的 探討腫瘤抑制基因甲基化與胃癌的關(guān)系。方法 對(duì)近年來(lái)關(guān)于腫瘤抑制基因甲基化與胃癌關(guān)系的文獻(xiàn)進(jìn)行綜述分析。 結(jié)果 胃癌中，細(xì)胞周期調(diào)控基因、有絲分裂檢測(cè)點(diǎn)基因、凋亡相關(guān)基因、錯(cuò)配修復(fù)基因、轉(zhuǎn)移相關(guān)基因等多種腫瘤抑制基因發(fā)生甲基化而失活。結(jié)論 腫瘤抑制基因甲基化在胃癌的發(fā)生、發(fā)展過(guò)程中起重要作用，腫瘤抑制基因的甲基化有可能成為胃癌診斷、判斷轉(zhuǎn)移和評(píng)價(jià)預(yù)后的分子標(biāo)記物，去甲基化干預(yù)有望成為胃癌治療的新方法。
引用本文： 楊少輝,戴冬秋. 腫瘤抑制基因甲基化與胃癌△. 中國(guó)普外基礎(chǔ)與臨床雜志, 2006, 13(5): 614-616. doi: 復(fù)制
| 1. | Reik W, Dean W, Walter J. Epigenetic reprogramming in ma-mmalian development [J]. Science， 2001; 293(5532)∶1089. |
| 2. | Robertson KD, Jones PA. DNA methylation: past， present and future directions [J]. Carcinogenesis, 2000; 21(3)∶461. |
| 3. | Attwood JT, Yung RL, Richardson BC. DNA methylation and the regulation of gene transcription [J].Cell Mol Life Sci， 2002; 59(2)∶241. |
| 4. | Yan L, Yang X, Davidson NE. Role of DNA methylation and histone acetylation in steroid receptor expression in breast cancer [J]. J Mammary Gland Biol Neoplasia， 2001; 6(2)∶183. |
| 5. | Pfeifer GP, Tang M, Denissenko MF. Mutation hotspots and DNA methylation [J]. Curr Top Microbiol Immunol， 2000; 249（1）∶1. |
| 6. | Kang GH, Lee S, Kim JS, et al. Profile of aberrant CpG island methylation along the multistep pathway of gastric carcinogenesis [J]. Lab Invest， 2003; 83(5)∶635. |
| 7. | Ding Y, Le XP, Zhang QX, et al. Methylation and mutation analysis of p16 gene in gastric cancer [J]. World J Gastroenterol， 2003; 9(3)∶423. |
| 8. | Lee JH, Park SJ, Abraham SC, et al. Frequent CpG island methylation in precursor lesions and early gastric adenocarcinomas [J]. Oncogene， 2004; 23(26)∶4646. |
| 9. | Lee TL, Leung WK, Chan MW, et al. Detection of gene promoter hypermethylation in the tumor and serum of patients with gastric carcinoma [J]. Clin Cancer Res， 2002; 8(6)∶1761. |
| 10. | Kang HC, Kim IJ, Park JH, et al. Promoter hypermethylation and silencing of CHFR mitotic stress checkpoint gene in human gastric cancers [J]. Oncol Rep， 2004; 12(1)∶129. |
| 11. | Murai M, Toyota M, Suzuki H, et al. Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer [J]. Clin Cancer Res， 2005; 11(3)∶1021. |
| 12. | Jung HY, Jung KC, Shim YH, et al. Methylation of the hMLH1 promoter in multiple gastric carcinomas with microsatellite instability [J]. Pathol Int， 2001; 51(6)∶445. |
| 13. | Nakajima T, Akiyama Y, Shiraishi J, et al. Age-related hypermethylation of the hMLH1 promoter in gastric cancers [J]. Int J Cancer， 2001; 94(2)∶208. |
| 14. | Oue N, Shigeishi H, Kuniyasu H, et al. Promoter hypermethylation of MGMT is associated with protein loss in gastric carcinoma [J]. Int J Cancer， 2001; 93(6)∶805. |
| 15. | Hong SH, Kim HG, Chung WB, et al. DNA hypermethylation of tumor-related genes in gastric carcinoma [J]. J Korean Med Sci， 2005; 20(2)∶236. |
| 16. | Hazan RB, Qiao R, Keren R, et al. Cadherin switch in tumor progression [J]. Ann N Y Acad Sci， 2004; 1014∶155. |
| 17. | 鄭志紅， 孫秀菊， 邱廣蓉， 等. 胃癌癌前和發(fā)展階段中E-cadherin基因的突變 [J]. 世界華人消化雜志， 2002; 10（2）∶153. |
| 18. | 鄭志紅， 孫秀菊， 馬鳴超， 等. 胃癌發(fā)展相關(guān)階段中E-cadherin基因啟動(dòng)子甲基化及蛋白表達(dá)的研究 [J]. 遺傳學(xué)報(bào)， 2003; 30（2）∶103. |
| 19. | Santini V, Kantarjian HM, Issa JP. Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications [J]. Ann Intern Med, 2001; 134(7)∶573. |
- 1. Reik W, Dean W, Walter J. Epigenetic reprogramming in ma-mmalian development [J]. Science， 2001; 293(5532)∶1089.
- 2. Robertson KD, Jones PA. DNA methylation: past， present and future directions [J]. Carcinogenesis, 2000; 21(3)∶461.
- 3. Attwood JT, Yung RL, Richardson BC. DNA methylation and the regulation of gene transcription [J].Cell Mol Life Sci， 2002; 59(2)∶241.
- 4. Yan L, Yang X, Davidson NE. Role of DNA methylation and histone acetylation in steroid receptor expression in breast cancer [J]. J Mammary Gland Biol Neoplasia， 2001; 6(2)∶183.
- 5. Pfeifer GP, Tang M, Denissenko MF. Mutation hotspots and DNA methylation [J]. Curr Top Microbiol Immunol， 2000; 249（1）∶1.
- 6. Kang GH, Lee S, Kim JS, et al. Profile of aberrant CpG island methylation along the multistep pathway of gastric carcinogenesis [J]. Lab Invest， 2003; 83(5)∶635.
- 7. Ding Y, Le XP, Zhang QX, et al. Methylation and mutation analysis of p16 gene in gastric cancer [J]. World J Gastroenterol， 2003; 9(3)∶423.
- 8. Lee JH, Park SJ, Abraham SC, et al. Frequent CpG island methylation in precursor lesions and early gastric adenocarcinomas [J]. Oncogene， 2004; 23(26)∶4646.
- 9. Lee TL, Leung WK, Chan MW, et al. Detection of gene promoter hypermethylation in the tumor and serum of patients with gastric carcinoma [J]. Clin Cancer Res， 2002; 8(6)∶1761.
- 10. Kang HC, Kim IJ, Park JH, et al. Promoter hypermethylation and silencing of CHFR mitotic stress checkpoint gene in human gastric cancers [J]. Oncol Rep， 2004; 12(1)∶129.
- 11. Murai M, Toyota M, Suzuki H, et al. Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer [J]. Clin Cancer Res， 2005; 11(3)∶1021.
- 12. Jung HY, Jung KC, Shim YH, et al. Methylation of the hMLH1 promoter in multiple gastric carcinomas with microsatellite instability [J]. Pathol Int， 2001; 51(6)∶445.
- 13. Nakajima T, Akiyama Y, Shiraishi J, et al. Age-related hypermethylation of the hMLH1 promoter in gastric cancers [J]. Int J Cancer， 2001; 94(2)∶208.
- 14. Oue N, Shigeishi H, Kuniyasu H, et al. Promoter hypermethylation of MGMT is associated with protein loss in gastric carcinoma [J]. Int J Cancer， 2001; 93(6)∶805.
- 15. Hong SH, Kim HG, Chung WB, et al. DNA hypermethylation of tumor-related genes in gastric carcinoma [J]. J Korean Med Sci， 2005; 20(2)∶236.
- 16. Hazan RB, Qiao R, Keren R, et al. Cadherin switch in tumor progression [J]. Ann N Y Acad Sci， 2004; 1014∶155.
- 17. 鄭志紅， 孫秀菊， 邱廣蓉， 等. 胃癌癌前和發(fā)展階段中E-cadherin基因的突變 [J]. 世界華人消化雜志， 2002; 10（2）∶153.
- 18. 鄭志紅， 孫秀菊， 馬鳴超， 等. 胃癌發(fā)展相關(guān)階段中E-cadherin基因啟動(dòng)子甲基化及蛋白表達(dá)的研究 [J]. 遺傳學(xué)報(bào)， 2003; 30（2）∶103.
- 19. Santini V, Kantarjian HM, Issa JP. Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications [J]. Ann Intern Med, 2001; 134(7)∶573.