目的:總結(jié)肝移植圍手術(shù)期應(yīng)用分子吸附循環(huán)系統(tǒng)（MARS）人工肝的經(jīng)驗(yàn)。
方法:回顧分析19例48次MARS人工肝治療的療效。
結(jié)果:單次或多次MARS人工肝治療能顯著降低血清總膽紅素、間接膽紅素、血氨、尿素氮、肌酐、尿酸等水平。19例患者中15例成功過渡到肝移植治療； 1例因免疫抑制劑中毒經(jīng)MARS人工肝治療癥狀改善； 1例移植肝功能好轉(zhuǎn)； 1例晚期肝硬變患者治療后肝性腦病癥狀得到緩解，因各種原因不愿再行肝移植，出院后2周死亡； 1例患者因上消化道大出血未能等到肝移植而死亡。治療成功率為89.5%。
結(jié)論:MARS人工肝是治療肝功能衰竭安全而有效的輔助方法，為使患者能過渡到肝移植創(chuàng)造了機(jī)會(huì)。
引用本文： 明英姿,葉啟發(fā),袁金忠. MARS人工肝在肝移植圍手術(shù)期中的應(yīng)用. 中國普外基礎(chǔ)與臨床雜志, 2005, 12(2): 127-129下轉(zhuǎn)134. doi: 復(fù)制
| 1. | Mitzner SR, Stange J, Klammt S, et al. Extracorporeal detoxification using the molecular adsorbent recirculating system for critically ill patients with liver failure [Ｊ]. J Am Soc Nephrol， 2001; 12(Suppl 17)∶S75. |
| 2. | Stange J, Mitzner S, Ramlow W, et al. A new procedure for the removal of protein bound drugs and toxins [Ｊ]. ASAIO J, 1993; 39(3)∶M621. |
| 3. | Mitzner SR, Stange J, Klammt S, et al. Extracorporeal detoxification using the molecular adsorbent recirculating system for critically ill patients with liver failure [Ｊ]. J Am Soc Nephrol, 2001; 12(Suppl 17)∶S75. |
| 4. | Schmidt LE, Sorensen VR, Svendsen LB, et al. Hemodynamic changes during a single treatment with the molecular adsorbents recirculating system in patients with acuteonchronic liver failure [Ｊ]. Liver Transpl, 2001; 7(12)∶1034. |
| 5. | Schmidt LE, Svendsen LB, Sorensen VR, et al. Cerebral blood flow velocity increases during a single treatment with the molecular adsorbents recirculating system in patients with acute on chronic liver failure [Ｊ]. Liver Transpl, 2001; 7(8)∶709. |
| 6. | Sorkine P, Ben Abraham R, Szold O, et al. Role of the molecular adsorbent recycling system (MARS) in the treatment of patients with acute exacerbation of chronic liver failure [Ｊ]. Crit Care Med, 2001; 29(7)∶1332. |
- 1. Mitzner SR, Stange J, Klammt S, et al. Extracorporeal detoxification using the molecular adsorbent recirculating system for critically ill patients with liver failure [Ｊ]. J Am Soc Nephrol， 2001; 12(Suppl 17)∶S75.
- 2. Stange J, Mitzner S, Ramlow W, et al. A new procedure for the removal of protein bound drugs and toxins [Ｊ]. ASAIO J, 1993; 39(3)∶M621.
- 3. Mitzner SR, Stange J, Klammt S, et al. Extracorporeal detoxification using the molecular adsorbent recirculating system for critically ill patients with liver failure [Ｊ]. J Am Soc Nephrol, 2001; 12(Suppl 17)∶S75.
- 4. Schmidt LE, Sorensen VR, Svendsen LB, et al. Hemodynamic changes during a single treatment with the molecular adsorbents recirculating system in patients with acuteonchronic liver failure [Ｊ]. Liver Transpl, 2001; 7(12)∶1034.
- 5. Schmidt LE, Svendsen LB, Sorensen VR, et al. Cerebral blood flow velocity increases during a single treatment with the molecular adsorbents recirculating system in patients with acute on chronic liver failure [Ｊ]. Liver Transpl, 2001; 7(8)∶709.
- 6. Sorkine P, Ben Abraham R, Szold O, et al. Role of the molecular adsorbent recycling system (MARS) in the treatment of patients with acute exacerbation of chronic liver failure [Ｊ]. Crit Care Med, 2001; 29(7)∶1332.