• 中南大學湘雅二醫(yī)院老年外科（長沙410011）;

【摘要】目的 探討生長激素（GH）對結腸癌細胞的作用，為其臨床應用的安全性研究提供實驗依據(jù)。
方法 建立人結腸癌細胞株SW480裸鼠移植瘤模型，觀察GH對移植瘤的作用； 5-FU和GH聯(lián)合干預體外培養(yǎng)SW480細胞株，通過MTT法觀察細胞生長變化。
結果 GH組移植瘤的體積、平均直徑及重量均顯著高于對照組（P＜0.05）； 通過MTT法觀察到GH組A值顯著高于對照組（P＜0.01），而5-FU與GH聯(lián)合干預組則明顯低于對照組（P＜0.01）。
結論 GH對結腸癌細胞具有顯著的促生長作用； GH與細胞周期特異性化療藥物的聯(lián)合應用具有一定安全性，并有可能成為化療增敏劑。

引用本文： 周建平,劉祺. 生長激素對人結腸癌細胞作用的研究. 中國普外基礎與臨床雜志, 2005, 12(4): 390-392. doi: 復制

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4. Cohen P, Clemmons DR, Rosenfeld RG. Dose the GHIGF axis play a role in cancer pathogenesis? [Ｊ]. Growth Horm IGF Res, 2000; 10(6)∶297.
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7. Busto R, Schally AV, Varga JL, et al. The expression of growth hormonereleasing hormone (GHRH) and splice variants of its receptor in human gastroenteropancreatic carcinomas [Ｊ]. Proc Natl Acad Sci USA, 2002; 99(18)∶11866.
8. 祁曉平，黎介壽，陳徹. 人生長激素對人結腸癌細胞LS174T增殖周期的影響 [Ｊ]. 腸外與腸內(nèi)營養(yǎng)， 2001; 8(1)∶8.
9. 祁曉平，黎介壽，陳 徹. 人生長激素對結腸癌細胞株細胞周期動力學的影響 [Ｊ]. 腸外與腸內(nèi)營養(yǎng)， 2000; 7(2)∶83.
10. 陳嘉勇，甘平，徐鵬遠，等. 生長激素對老年消化道腫瘤患者術后蛋白分解代謝和免疫功能的影響 [Ｊ]. 中國老年學雜志， 2000; 20(5)∶162.
  1. 1. Swerdlow AJ, Higgins CD, Adlard P，et al. Risk of cancer in patients treated with human pituitary growth hormone in the UK, 1959-85: a cohort study [Ｊ]. JPLancet, 2002; 360(9329)∶273.
  2. 2. Jauch KW, Heiss MM, Gruetzner U, et al. Prognostic significance of bone marrow micrometastases in patients with gastric cancer [Ｊ]. J Clin Oncol, 1996; 14(6)∶1810.
  3. 3. Hermanek P. pTNM and residual tumor classifications: problems of assessment and prognostic significance [Ｊ]. World J Surg, 1995; 19(2)∶184.
  4. 4. Cohen P, Clemmons DR, Rosenfeld RG. Dose the GHIGF axis play a role in cancer pathogenesis? [Ｊ]. Growth Horm IGF Res, 2000; 10(6)∶297.
  5. 5. Morante J, VallejoCremades MT, GomezGarcia L, et al. Differential action of growth hormone in irradiated tumoral and nontumoral intestinal tissue [Ｊ]. Dig Dis Sci, 2003; 48(11)∶2159.
  6. 6. Bustin SA, Jenkins PJ. The growth hormoneinsulinlike growth factorI axis and colorectal cancer [Ｊ]. Trends Mol Med, 2001; 7(10)∶447.
  7. 7. Busto R, Schally AV, Varga JL, et al. The expression of growth hormonereleasing hormone (GHRH) and splice variants of its receptor in human gastroenteropancreatic carcinomas [Ｊ]. Proc Natl Acad Sci USA, 2002; 99(18)∶11866.
  8. 8. 祁曉平，黎介壽，陳徹. 人生長激素對人結腸癌細胞LS174T增殖周期的影響 [Ｊ]. 腸外與腸內(nèi)營養(yǎng)， 2001; 8(1)∶8.
  9. 9. 祁曉平，黎介壽，陳 徹. 人生長激素對結腸癌細胞株細胞周期動力學的影響 [Ｊ]. 腸外與腸內(nèi)營養(yǎng)， 2000; 7(2)∶83.
  10. 10. 陳嘉勇，甘平，徐鵬遠，等. 生長激素對老年消化道腫瘤患者術后蛋白分解代謝和免疫功能的影響 [Ｊ]. 中國老年學雜志， 2000; 20(5)∶162.