• 1.上海市黃浦區(qū)中心醫(yī)院外科(上海200002);;
  • 2.哈爾濱醫(yī)科大學(xué)附屬第一醫(yī)院普外科(哈爾濱150001);

目的  探討透明質(zhì)酸鈉對(duì)術(shù)后腹腔粘連的預(yù)防作用。
方法  將38只大鼠隨機(jī)分為A、B、C 3組，于腹腔內(nèi)損傷部位分別注入生理鹽水、6%右旋糖酐-40和透明質(zhì)酸鈉(術(shù)康林1)，術(shù)后第14天處死動(dòng)物，觀察各組腹腔粘連情況。
結(jié)果  3組粘連分級(jí)差異有顯著性意義(Ｐ＜0.01)。光鏡下見C組炎癥反應(yīng)輕微，纖維增生不顯著； 電鏡下見C組纖維細(xì)胞分泌膠原能力弱，間質(zhì)細(xì)胞增生活躍。
結(jié)論  透明質(zhì)酸鈉可減少術(shù)后腹腔粘連的程度，其作用優(yōu)于右旋糖酐。

引用本文： 楊新平,姜洪池. 透明質(zhì)酸鈉預(yù)防術(shù)后腹腔粘連的實(shí)驗(yàn)研究. 中國普外基礎(chǔ)與臨床雜志, 2000, 7(1): 16-18. doi: 復(fù)制

1. ScottCoombers D, Whawell SA, Vipond MN, et al. Human intraperitoneal fibrinolytic response to surgery 〔Ｊ〕. Br J Surg, 1995; 82(3)∶414.
2. Trentner KH, Bertram P, Loser S, et al. Prevention and therapy of intraabdominal adhesions. A survey of 1 200 clinics in Germany 〔Ｊ〕. Chirurg, 1995; 66(4)∶398.
3. Holtz G. Prevention and management of peritoneal adhesions 〔Ｊ〕. Fertil Steril, 1984; 41(4)∶497.
4. 胡建敏， 黃紹賢， 侯忠民等. 人體脂肪、alpha糜蛋白酶聯(lián)合腹腔灌注預(yù)防粘連的實(shí)驗(yàn)及臨床研究 〔Ｊ〕. 中華實(shí)驗(yàn)外科雜志， 1989； 6(3)∶101.
5. Dillon PW, Keefer K, Blackburn JH, et al. The extracellular matrix of the fetal wound: hyaluronic acid controls lymphocyte adhesion 〔Ｊ〕. J Surg Res, 1994; 57(1)∶170.
6. Urman B, Gomel V, Jetha N. Effect of hyaluronic acid on postoperative intraperitoneal adhesion formation in the rat model 〔Ｊ〕. Fertil Steril, 1991; 56(3)∶563.
7. Yarali H, Zahradka BF, Gomel V. Hyaluronic acid membrane for reducing adhesion formation and reformation in the rat uterine horn 〔Ｊ〕. J Reprod Med, 1994; 39(9)∶667.
8. Holzman S, Connolly RT, Schwaitzberg SD. Effect of hyaluronic acid solution on healing of bowel anastomoses 〔Ｊ〕. J Invest Surg, 1994; 7(5)∶431.
  1. 1. ScottCoombers D, Whawell SA, Vipond MN, et al. Human intraperitoneal fibrinolytic response to surgery 〔Ｊ〕. Br J Surg, 1995; 82(3)∶414.
  2. 2. Trentner KH, Bertram P, Loser S, et al. Prevention and therapy of intraabdominal adhesions. A survey of 1 200 clinics in Germany 〔Ｊ〕. Chirurg, 1995; 66(4)∶398.
  3. 3. Holtz G. Prevention and management of peritoneal adhesions 〔Ｊ〕. Fertil Steril, 1984; 41(4)∶497.
  4. 4. 胡建敏， 黃紹賢， 侯忠民等. 人體脂肪、alpha糜蛋白酶聯(lián)合腹腔灌注預(yù)防粘連的實(shí)驗(yàn)及臨床研究 〔Ｊ〕. 中華實(shí)驗(yàn)外科雜志， 1989； 6(3)∶101.
  5. 5. Dillon PW, Keefer K, Blackburn JH, et al. The extracellular matrix of the fetal wound: hyaluronic acid controls lymphocyte adhesion 〔Ｊ〕. J Surg Res, 1994; 57(1)∶170.
  6. 6. Urman B, Gomel V, Jetha N. Effect of hyaluronic acid on postoperative intraperitoneal adhesion formation in the rat model 〔Ｊ〕. Fertil Steril, 1991; 56(3)∶563.
  7. 7. Yarali H, Zahradka BF, Gomel V. Hyaluronic acid membrane for reducing adhesion formation and reformation in the rat uterine horn 〔Ｊ〕. J Reprod Med, 1994; 39(9)∶667.
  8. 8. Holzman S, Connolly RT, Schwaitzberg SD. Effect of hyaluronic acid solution on healing of bowel anastomoses 〔Ｊ〕. J Invest Surg, 1994; 7(5)∶431.