目的 探討p16和p53蛋白在膽囊癌發(fā)生、發(fā)展中的作用及其相關(guān)性。
方法 應(yīng)用免疫組化法對(duì)40例膽囊癌組織中p16和p53蛋白的表達(dá)情況進(jìn)行檢測(cè)。
結(jié)果 p16和p53蛋白的表達(dá)與膽囊癌的組織學(xué)分化，淋巴結(jié)轉(zhuǎn)移以及預(yù)后相關(guān)； p16蛋白的表達(dá)還與臨床分期有關(guān)。結(jié)論 p16蛋白的失表達(dá)是發(fā)生在膽囊癌發(fā)展的晚期階段，認(rèn)為p16和p53蛋白的表達(dá)有助于原發(fā)性膽囊癌的分化及其預(yù)后的判斷。
引用本文： 張東,馮德元,王平,鄒賽英,何澤生. 抑癌基因p16和p53在原發(fā)性膽囊癌中的表達(dá)及其相關(guān)性的初步研究. 中國(guó)普外基礎(chǔ)與臨床雜志, 2000, 7(2): 85-86. doi: 復(fù)制
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- 2. Walker DG, Duan W, Popovic EA, et al. Homozygous deletions of the multiple tumor suppressor gene 1 in the progression of human astrocytomas 〔Ｊ〕. Cancer Res, 1995; 55(1)∶20.
- 3. Fujimoto K, Yamada Y, Okajima E, et al. Frequent association of p53 gene mutation in invasive bladder cancer 〔Ｊ〕. Cancer Res, 1992; 52(6)∶1393.
- 4. Rigaudy P, Echhart W. Nucleotide sequence of a CDNA encoding the monkey cellular phosphoprotein p53 〔Ｊ〕. Nucleic Acids Res, 1989; 17(20)∶8375.