目的 探討大鼠急性胰腺炎(AP)時胰組織磷脂酶A2(PLA2)的變化及異搏定治療作用。
方法 采用“十二指腸閉袢法”誘發(fā)AP大鼠模型設(shè)定AP組和異搏定組，對比觀察AP組和異搏定治療組PLA2活性變化及胰組織病理學(xué)檢查。
結(jié)果 誘發(fā)AP 16小時和24小時胰腺組織PLA2活性，治療組分別為32.34±3.87 u和35.26±4.52 u，AP組分別為44.83±5.31 u和47.77±5.86 u，治療組較AP組明顯降低，病理改變減輕。
結(jié)論 大鼠AP時存在PLA2的活化，鈣通道阻滯劑異搏定可抑制PLA2的活化，推測對大鼠AP有一定的治療作用。
引用本文： 周新澤,毛勤生,陳玉泉. 大鼠急性胰腺炎時磷脂酶A2的變化及異搏定治療作用的研究. 中國普外基礎(chǔ)與臨床雜志, 2000, 7(6): 360-361. doi: 復(fù)制
| 1. | Gustafson C, Lindahl M, Tagesson C. Hydrogen peroxide stimulates phospholipase Ａ2 mediated arachidonic acid release in cultured intestinal epithelial cell 〔Ｊ〕. Scand J Gastroenterol, 1991; 26(3)∶237. |
| 2. | Nevalainen TJ, Seppa A. Acute pancreatitis caused by closed duodenal loop in the rat 〔Ｊ〕. Scand J Gastroenterol, 1975; 10(6)∶521. |
| 3. | Rao SS. A serial histologic study of the development and progression of acute pancreatitis in the rat 〔Ｊ〕. Am J Pathol, 1981; 103(4)∶39. |
| 4. | Inagaki T, Hoshino M, Ohara H, et al. Evaluation of phosphlipase Ａ2 measurement for early prediction of the severity of acute pancreatitis 〔Ｊ〕. Pancreas, 1998; 16(4)∶558. |
- 1. Gustafson C, Lindahl M, Tagesson C. Hydrogen peroxide stimulates phospholipase Ａ2 mediated arachidonic acid release in cultured intestinal epithelial cell 〔Ｊ〕. Scand J Gastroenterol, 1991; 26(3)∶237.
- 2. Nevalainen TJ, Seppa A. Acute pancreatitis caused by closed duodenal loop in the rat 〔Ｊ〕. Scand J Gastroenterol, 1975; 10(6)∶521.
- 3. Rao SS. A serial histologic study of the development and progression of acute pancreatitis in the rat 〔Ｊ〕. Am J Pathol, 1981; 103(4)∶39.
- 4. Inagaki T, Hoshino M, Ohara H, et al. Evaluation of phosphlipase Ａ2 measurement for early prediction of the severity of acute pancreatitis 〔Ｊ〕. Pancreas, 1998; 16(4)∶558.