• 第三軍醫(yī)大學(xué)西南醫(yī)院普外科(重慶400038);

目的  探討抑癌基因在多原發(fā)性惡性腫瘤(MPMN)發(fā)生中的重要作用。
方法  采用回顧性分析的方法對(duì)近年來(lái)多原發(fā)性惡性腫瘤中常見(jiàn)的相關(guān)抑癌基因研究進(jìn)行了綜述。
結(jié)果  目前在多原發(fā)性惡性腫瘤研究中，研究較多的抑癌基因有p53、APC、p16、BRCA1、BRCA2、PTEN/MMAC1等基因，許多MPMN可檢測(cè)出相同的抑癌基因突變。
結(jié)論  多原發(fā)性惡性腫瘤發(fā)生與抑癌基因失活有重要關(guān)系，通過(guò)對(duì)抑癌基因在MPMN中作用的研究，可揭示出MPMN發(fā)生的某些共同規(guī)律。

引用本文： 張毅 綜述 姜軍 審校. 抑癌基因失活在多原發(fā)性惡性腫瘤發(fā)生中的意義. 中國(guó)普外基礎(chǔ)與臨床雜志, 2000, 7(6): 418-420. doi: 復(fù)制

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2. Sinicrope FA, Rvan SB, Cleary RR, et al. Bcl2 and p53 oncoprotein expression during colorectal tumorigenes 〔Ｊ〕. Cancer Res, 1995; 55(2)∶237.
3. Harris CG. Structure and function of the p53 tumor suppressor gene: clues for rational cancer therapeutic strategies 〔Ｊ〕. J Natl Cancer Inst, 1996; 88(20)∶1442.
4. Mitsudomi T, Yatabe Y, Kosshikawa T, et al. Mutations of the p53 tumor suppressor gene as clonal marker for multiple primary lung cancers 〔Ｊ〕. J Thorac Cardiovasc Surg, 1997; 114(3)∶354.
5. Hisada M, Garber JE, Fung CY, et al. Multiple primary cancers in families with LiFraumeni syndrome 〔Ｊ〕. J Notl Cancer Inst, 1998; 90(8)∶606.
6. Alconchel MD, Olivares C, Alvarez R, et al. Squamous cell carcinoma, malignant melanoma and malignant fibrous histiocytoma arising in burn scars 〔Ｊ〕. Br J Dermatol, 1997; 137(5)∶793.
7. Sparks AB, Morin PJ, Vogolstegn B, et al. Mutational analuyusis of the APC/βcatenin/TCF pathway in colorectal cancer 〔Ｊ〕. Cancer Res, 1998; (6)∶1130.
8. Mahmoud NN, Boolbol SK, Bilinski RT, et al. APC gene mutations is assoceated with a dominantnegative effect up intestinal cell migration 〔Ｊ〕. Cancer Res, 1997; 57(22)∶5045.
9. Milner J, Ponder B, Davies L, et al. Transcriptional activation 〔Ｊ〕. Nature, 1997; 386(6626)∶772.
10. Gorden J, Thliveris A, Samowitz W, et al. Identification and characterization of the familial adenomatous polyposis coli gene 〔Ｊ〕. Cell, 1991; 66(3)∶589.
11. Winchester DP. Breast cancer in young women 〔Ｊ〕. Surg Clin North Am, 1996; 76(2)∶279.
12. Easton DF, Bishop DT, Ford D, et al. Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families 〔Ｊ〕. Am J Hum Genet, 1993; 52(4)∶678.
13. Durocher F, Tonin P, Shattuck ED, et al. Mutation analysis of the BRCA1 gene in 23 families with cancers of the breast ovary and multiple other sites 〔Ｊ〕. J Med Genet, 1996; 33(11)∶814.
14. Radrord DM, Zehnbamer BA. Inherited breast cancer 〔Ｊ〕. Surg Clin North Am, 1996; 76(2)∶205.
15. Couch FJ, Deshano ML, Blackwood MN, et al. BRCA1 mutations in women attending clinics that evaluate the risk of breast cancer 〔Ｊ〕. N Engl J Med, 1997; 336(20)∶1409.
16. Easton DF, Narod SA, Fofd D, et al. The genetic epidemiology of BRCA1 〔Ｊ〕. Lancet, 1994; 344(8924)∶761.
17. Wooster R, Mangion J, Nevhausen SL, et al. Localization of a breast cancer susceptibility gene, BRCA2 to chromosome 13q1223 〔Ｊ〕. Science, 1994; 265(5181)∶2098.
18. Donegan WL, Redlich PN. Breast cancer in men 〔Ｊ〕. Surg Clin North Am, 1996; 76(2)∶343.
19. Kamb A, Gruis N, Liu QY, et al. A cell cycle regulator potentially involved in genesis of many tumor types 〔Ｊ〕. Science, 1994; 264(5157)∶436.
20. Nobori T, Miura K, Wu DJ, et al. Deletions of the cyclindependent kinase4 inhibitor gene in multiple human cancers 〔Ｊ〕. Nature, 1994; 368(6467)∶753.
21. Masx J. New tumor suppressor may rival p53 〔Ｊ〕. Science, 1994; 264(5157)∶344.
22. Monzon J, Liu L， Brill H, et al. CDKN2A mutations in multiple primary melanomas 〔Ｊ〕. N Engl J Med, 1998; 338(13)∶879.
23. Rhel E, Kang L, Bogomolniy F, et al. Mutation analysis of the putative tumour suppressor gene PTEN/MMAC1 in primary breast carcinomas 〔Ｊ〕. Cancer Res, 1997; 57(17)∶3657.
24. Kinzler KW, Vogelstien B. Gatekeepers and caretaker 〔Ｊ〕. Nature, 1997; 386(6626)∶761.
25. Sharan SK, Morimatsu M, Albrecht V, et al. Embryonic lethality and radiation hypersensitivity mediated by rad51 in mice lacking BRCA2 〔Ｊ〕. Nature, 1997; 386(6626)∶804.
  1. 1. Miki Y, Swensen J, Shattuck K, et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1 〔Ｊ〕. Science, 1994; 266(5188)∶66.
  2. 2. Sinicrope FA, Rvan SB, Cleary RR, et al. Bcl2 and p53 oncoprotein expression during colorectal tumorigenes 〔Ｊ〕. Cancer Res, 1995; 55(2)∶237.
  3. 3. Harris CG. Structure and function of the p53 tumor suppressor gene: clues for rational cancer therapeutic strategies 〔Ｊ〕. J Natl Cancer Inst, 1996; 88(20)∶1442.
  4. 4. Mitsudomi T, Yatabe Y, Kosshikawa T, et al. Mutations of the p53 tumor suppressor gene as clonal marker for multiple primary lung cancers 〔Ｊ〕. J Thorac Cardiovasc Surg, 1997; 114(3)∶354.
  5. 5. Hisada M, Garber JE, Fung CY, et al. Multiple primary cancers in families with LiFraumeni syndrome 〔Ｊ〕. J Notl Cancer Inst, 1998; 90(8)∶606.
  6. 6. Alconchel MD, Olivares C, Alvarez R, et al. Squamous cell carcinoma, malignant melanoma and malignant fibrous histiocytoma arising in burn scars 〔Ｊ〕. Br J Dermatol, 1997; 137(5)∶793.
  7. 7. Sparks AB, Morin PJ, Vogolstegn B, et al. Mutational analuyusis of the APC/βcatenin/TCF pathway in colorectal cancer 〔Ｊ〕. Cancer Res, 1998; (6)∶1130.
  8. 8. Mahmoud NN, Boolbol SK, Bilinski RT, et al. APC gene mutations is assoceated with a dominantnegative effect up intestinal cell migration 〔Ｊ〕. Cancer Res, 1997; 57(22)∶5045.
  9. 9. Milner J, Ponder B, Davies L, et al. Transcriptional activation 〔Ｊ〕. Nature, 1997; 386(6626)∶772.
  10. 10. Gorden J, Thliveris A, Samowitz W, et al. Identification and characterization of the familial adenomatous polyposis coli gene 〔Ｊ〕. Cell, 1991; 66(3)∶589.
  11. 11. Winchester DP. Breast cancer in young women 〔Ｊ〕. Surg Clin North Am, 1996; 76(2)∶279.
  12. 12. Easton DF, Bishop DT, Ford D, et al. Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families 〔Ｊ〕. Am J Hum Genet, 1993; 52(4)∶678.
  13. 13. Durocher F, Tonin P, Shattuck ED, et al. Mutation analysis of the BRCA1 gene in 23 families with cancers of the breast ovary and multiple other sites 〔Ｊ〕. J Med Genet, 1996; 33(11)∶814.
  14. 14. Radrord DM, Zehnbamer BA. Inherited breast cancer 〔Ｊ〕. Surg Clin North Am, 1996; 76(2)∶205.
  15. 15. Couch FJ, Deshano ML, Blackwood MN, et al. BRCA1 mutations in women attending clinics that evaluate the risk of breast cancer 〔Ｊ〕. N Engl J Med, 1997; 336(20)∶1409.
  16. 16. Easton DF, Narod SA, Fofd D, et al. The genetic epidemiology of BRCA1 〔Ｊ〕. Lancet, 1994; 344(8924)∶761.
  17. 17. Wooster R, Mangion J, Nevhausen SL, et al. Localization of a breast cancer susceptibility gene, BRCA2 to chromosome 13q1223 〔Ｊ〕. Science, 1994; 265(5181)∶2098.
  18. 18. Donegan WL, Redlich PN. Breast cancer in men 〔Ｊ〕. Surg Clin North Am, 1996; 76(2)∶343.
  19. 19. Kamb A, Gruis N, Liu QY, et al. A cell cycle regulator potentially involved in genesis of many tumor types 〔Ｊ〕. Science, 1994; 264(5157)∶436.
  20. 20. Nobori T, Miura K, Wu DJ, et al. Deletions of the cyclindependent kinase4 inhibitor gene in multiple human cancers 〔Ｊ〕. Nature, 1994; 368(6467)∶753.
  21. 21. Masx J. New tumor suppressor may rival p53 〔Ｊ〕. Science, 1994; 264(5157)∶344.
  22. 22. Monzon J, Liu L， Brill H, et al. CDKN2A mutations in multiple primary melanomas 〔Ｊ〕. N Engl J Med, 1998; 338(13)∶879.
  23. 23. Rhel E, Kang L, Bogomolniy F, et al. Mutation analysis of the putative tumour suppressor gene PTEN/MMAC1 in primary breast carcinomas 〔Ｊ〕. Cancer Res, 1997; 57(17)∶3657.
  24. 24. Kinzler KW, Vogelstien B. Gatekeepers and caretaker 〔Ｊ〕. Nature, 1997; 386(6626)∶761.
  25. 25. Sharan SK, Morimatsu M, Albrecht V, et al. Embryonic lethality and radiation hypersensitivity mediated by rad51 in mice lacking BRCA2 〔Ｊ〕. Nature, 1997; 386(6626)∶804.