【摘要】 目的 分析乳酸性酸中毒發(fā)生的危險(xiǎn)因素，警示臨床工作?！》椒ā』仡櫺苑治?008年5月—2010年12月收治的32例乳酸性酸中毒患者的臨床資料?！〗Y(jié)果 32例患者均合并2型糖尿病，其中老年患者27例（占84.6%）；20例有服用雙胍類降糖藥物史（占62.5%）；12例合并肺部疾病（占37.5%）；9例合并心臟疾病（占28.1%）；15例合并腎功能不全（占46.9%）；8例合并肝功能異常（占25.0%）?！〗Y(jié)論 糖尿病、老年、使用雙胍類藥物、合并心肺疾病及肝腎功能不全都是發(fā)生乳酸性酸中毒的危險(xiǎn)因素。在臨床工作中，對(duì)高?；颊咝杼岣呔?，盡量避免危險(xiǎn)因素疊加以減少乳酸性酸中毒的發(fā)生?！続bstract】 Objective To analyze the risk factors of lactic acidosis. Methods The clinical data of 32 patients with lactic acidosis admitted to our hospital from May 2008 to December 2010 were studied retrospectively. Results All patients had type 2 diabetes mellitus. Among them, 27 (84.6%) were older than 60, 20 (62.5%) had ingested antidiabetic drugs of biguanides, 12 (37.5%) were complicated by pulmonary diseases, 9 (28.1%) by heart diseases, 15 (46.9%) by renal dysfunction, and 8 (25.0%) by liver dysfunction. Conclusions Diabetes mellitus, old age, ingesting of biguanides, cardiopulmonary diseases, renal and hepatic dysfunction all contribute to the occurrence of lactic acidosis. During clinical work, we should try to avoid the above-mentioned risk factors.