【摘要】 目的 探討老年糖尿病患者血清胱抑素C與血脂及高敏C反應(yīng)蛋白的關(guān)系。 方法 2008年5月-2009年10月糖尿病患者共141例，其中糖尿病合并癥組68例，單純糖尿病組73例；另選取對照組51例。對入選者的血清胱抑素C、血脂及高敏C反應(yīng)蛋白進(jìn)行分析。 結(jié)果 老年男女糖尿病合并癥組血清胱抑素C、高敏C反應(yīng)蛋白、總膽固醇、甘油三酯及低密度脂蛋白膽固醇最高、高密度脂蛋白膽固醇最低，與對照組比較有統(tǒng)計(jì)學(xué)意義（Plt;0.05）、與單純糖尿病組比較，無統(tǒng)計(jì)學(xué)意義（Pgt;0.05）。老年男女單純糖尿病組高敏C反應(yīng)蛋白、總膽固醇、甘油三酯高于對照組，組間比較，有統(tǒng)計(jì)學(xué)意義（Plt;0.05）。老年男女單純糖尿病組血清胱抑素C與對照組比較，無統(tǒng)率學(xué)意義（Pgt;0.05）。老年女性單純糖尿病組低密度脂蛋白膽固醇與對照組比較，有統(tǒng)計(jì)學(xué)意義（Plt;0.05）。老年男性糖尿病二組與對照組血清胱抑素C低于老年女性糖尿病二組與對照組，組間比較，無統(tǒng)計(jì)學(xué)意義（Pgt;0.05）。老年男性糖尿病患者血清胱抑素C與高敏C反應(yīng)蛋白及血脂不相關(guān)。老年女性糖尿病合并癥組血清胱抑素C與空腹血糖正相關(guān)；單純糖尿病組血清胱抑素C與高密度脂蛋白膽固醇負(fù)相關(guān)、與低密度脂蛋白膽固醇正相關(guān)、與高敏C反應(yīng)蛋白不相關(guān)。 結(jié)論 老年糖尿病患者高脂、高糖及低度炎癥狀態(tài)下，血清胱抑素C水平較高。血脂對血清胱抑素C的影響可能存在性別差異。隨著動(dòng)脈粥樣硬化的加重，血清胱抑素C有升高趨勢。【Abstract】 Objective To investigate the relationship between serum cystatin C concentration and lipid, hs-C reactive protein in the elderly with diabetes. Methods A total of 192 senile people form May 2008 to October 2009 were investigated. There were 141 patients with diabetes, in whom 68 were with cardiovascular and cor, cerebrovascular diseases, 73 were with diabetes only.There were 51 control subjects. The data of serum cystatin C, hs-CRP, TC, TG, HDL-C and LDL-C were analyzed. Results Serum cystatin C of elderly men was lower than that in elderly women, but no signifcant correlation between them was found (Pgt;0.05). Serum cystatin C, hs-CRP, TC, TG and LDL-C was higher, and HDL-C was lower in male and female diabetes subjects with cardiovascular and cor, cerebrovascullar diseases, than that in control subjects (Plt;0.05). Serum hs-CRP, TC and TG were higher in the elderly with diabetes only, than that in control subjects (Plt;0.05). LDL-C was higher in senile women with diabetes only, than that in female control subjects (Plt;0.05). Serum cystatin C with LDL-C in elderly women with diabetes only, with FPG in female diabetes subjects with cardiovascular and cor, cerebrovascular diseases had position correlation (Plt;0.05). No correlation were observed between serum cystatin C and hs-CRP in male and female diabetes subjects, and lipid in male diabetes subjects. Conclusions We speculate that high serum lipid, high glucose and low level of inflammation may result in increasing of serum cystatin C in senily people with diabetes. The influence of serum lipid on serum cystatin C may be different in male and female senile people.Along with atherosclerotic aggravating, the level of serum cystatin C was increasing.
目的 觀察與分析體重異常老年男性血清前列腺特異性抗原（T-PSA）與生長激素（GH）水平及影響因素。 方法 以2009年1月－2012年6月，血清GH＜5 ng/mL、血清T-PSA＜4.5 ng/mL的老年男性共296例作為觀察對象，依據(jù)體質(zhì)量指數(shù)分為低體重組、正常體重組、超重組及肥胖組。依據(jù)年齡分為60～64、65～69、70～74及≥75歲四組。測定296例入選對象的血清T-PSA及GH并進(jìn)行分析。 結(jié)果 隨著年齡增長，血清T-PSA、GH漸增高?！?5歲年齡組血清T-PSA高于其他三組，差異無統(tǒng)計(jì)學(xué)意義（P＞0.05）?！?5歲年齡組血清GH高于其他三組，差異有統(tǒng)計(jì)學(xué)意義（P＜0.01）。超重組及肥胖組血清T-PSA低于正常體重組，差異有統(tǒng)計(jì)學(xué)意義（P＜0.01）。低體重組血清T-PSA稍低于正常體重組，差異無統(tǒng)計(jì)學(xué)意義（P＞0.05）。肥胖組血清GH低于超重及正常體重組，差異無統(tǒng)計(jì)學(xué)意義（P＞0.05）。低體重組血清GH低于正常體重組，差異無統(tǒng)計(jì)學(xué)意義（P＞0.05）。單因素相關(guān)分析顯示血清T-PSA與年齡、GH正相關(guān)；與BMI負(fù)相關(guān)；與收縮壓（SBP）、舒張壓（DBP）、空腹血糖（FPG）及血脂不相關(guān)。血清GH與年齡、T-PSA、SBP、DBP正相關(guān)；與BMI、FPG及血脂不相關(guān)。校正年齡、BMI后，血清T-PSA與GH仍呈正相關(guān)。 結(jié)論 隨著年齡增長，老年男性血清T-PSA、GH漸增高。老年男性非肢端肥大癥者血清T-PSA與血清GH水平及BMI有關(guān)聯(lián)，血清GH水平較高者，血清T-PSA也較高；血清T-PSA與BMI負(fù)相關(guān)。
目的:探討老年代謝綜合征者血清尿酸與血壓、甘油三脂的關(guān)系。方法:163例入選者,MS組96例,對照組67例,對二組的SUA、BMI、WC 、SBP、DBP及TG進(jìn)行分析。結(jié)果:MS組SUA較對照組高。MS組男性SUA與BMI正相關(guān)、女性與WC正相關(guān);男女性MS組及對照組SUA與SBP及TG不相關(guān)。對照組女性SUA與DBP正相關(guān)。結(jié)論:SUA對老年女性DBP的維持可能有一定作用。TG對老年人SUA的影響有限;體重及脂肪聚集部位對SUA的影響,存在性別差異。