摘要:目的: 隨機(jī)對(duì)照研究、評(píng)估生物反饋訓(xùn)練治療慢性功能性便秘的療效。 方法 : 60例慢性功能性便秘患者,隨機(jī)分為治療組30例和對(duì)照組30例。治療組接受1個(gè)療程(5周)生物反饋訓(xùn)練治療(10次為一個(gè)療程、一次30～45分鐘、每周2次)。對(duì)照組患者接受聚乙二醇4000 10g BID 口服,療程5周。治療前后作便秘癥狀評(píng)分、結(jié)腸通過試驗(yàn)檢測(cè)、直腸肛門壓力檢測(cè)。 結(jié)果 : 生物反饋訓(xùn)練和聚乙二醇4000均可使多數(shù)慢性功能性便秘患者的大便次數(shù)、大便性狀及伴隨癥狀恢復(fù)正?；蚓徑?總有效率分別為667%和80%(P ＞005)。生物反饋訓(xùn)練和聚乙二醇4000口服治療后,結(jié)腸通過試驗(yàn)72小時(shí)標(biāo)志物排出率分別為75%及73%,均較治療前明顯增加。生物反饋訓(xùn)練治療后力排時(shí)肛門壓明顯下降。 結(jié)論 : 生物反饋訓(xùn)練對(duì)出口梗阻型、慢傳輸型便秘均有效,是一種有效的、新興的治療慢性功能性便秘的方法,可作為功能性便秘的一線治療方法。Abstract: Objective: To assess the clinic effect of biofeedback therapy for functional constipation. Methods : Sixty cases of chronic functional constipation were randomly divided into treatment group (30 cases) and control group (30 cases). Cases in the treatment group were exposed to biofeedback for a fiveweeklong treatment course—individual treatment lasted for 3045 minutes and twice per week. Patients in the control group received PEG 4000 10g BID for five weeks. Data from constipation symptom score, colonic transit test, and anorectal manometry were done and compared before and after two kinds of treatments. Results : Biofeedback training and PEG 4000 could restore the stoolfrequency, stool characteristics and accompanying symptoms to normal or mitigation of the majority of patients with chronic functional constipation, with the total effective rates being 667% and 80% (P gt;005), respectively. After biofeedback training and PGE 4000 treatment, the discharge rate of 72hour markers of colonic transit test significantly increased to 75% and 73%, respectively. Additionally, anorectal pressure decreased dramatically after biofeedback training. Conclusion : Biofeedback training would play a positive role in outlet obstruction and slow transit constipation. Thus, it could be an effective firstline treatment of chronic functional constipation.