【摘要】 目的 探討胎兒宮內(nèi)窘迫對足月新生兒血清心肌酶變化的相關(guān)性分析?！》椒ā?009年10月-2010年9月在我產(chǎn)科出生有宮內(nèi)窘迫史而羊水和Apgar評分均正常的足月新生兒20例為觀察組，同期出生的健康足月新生兒10例為對照組，分別測定兩組出生后1、5 d血清肌酸激酶同工酶（CK-MB）及心肌肌鈣蛋白I（cTnI）水平。 結(jié)果 觀察組出生后1 d血清cTnI高于對照組（Plt;0.001），CK-MB兩組差異無統(tǒng)計(jì)學(xué)意義（Pgt;0.05），出生后5 d血清CK-MB及cTnI均高于對照組（Plt;0.001）；觀察組和對照組出生后5 d血清cTnI水平均較1 d時(shí)升高，差異有統(tǒng)計(jì)學(xué)意義（Plt;0.001），血清CK-MB濃度均低于1 d時(shí)（Plt;0.001）。觀察組患兒經(jīng)過治療，1個(gè)月后復(fù)查血清cTnI除1例未恢復(fù)至正常水平外，其余血清CK-MB及心電圖均恢復(fù)正常?！〗Y(jié)論 單純宮內(nèi)窘迫可造成足月新生兒血清cTnI及CK-MB水平升高，常規(guī)檢測血清cTnI及CK-MB能及時(shí)了解此類新生兒的心肌受損情況，從而盡早予以保護(hù)心肌治療?！続bstract】 Objective To make a correlation analysis on effect of fetal distress on changes of cardiac enzyme in neonatal serum. Methods Twenty full-term newborns who met diagnostic criteria of fetal distress but were born with normal amniotic fluid and Apgar score between October 2009 and September 2010 were included in the observed group, another ten normal full-term newborns born at same period were in control group. The serum values of cardiac troponin I (cTnI) and creatine kinase (CK-MB) were collected and measured one and five days after birth. Results One day after the birth, the serum levels of cTnI was significantly higher in the observed group compared to that in the control group (Plt;0.001), but there was no difference in CK-MB between the two groups (Pgt;0.05). The values of cTnI five days after the birth were higher than those one days after the birth in both groups (Plt;0.001). The values of CK-MB were higher one day after birth than those five days after birth in both groups (Plt;0.001). In observation group after the treatment, serum cTnI in one patient did not return to normal, and the remaining neonatal serum CK-MB and ECG were normal. Conclusions Elevated level of serum cTnI and CK-mb could be caused by fetal distress in normal full-term newborns with normal amniotic fluid and Apgar score. Routine testing of serum cTnI and CK-MB may be useful to detect myocardial damage in newborns.