【摘要】 目的 分析乳酸性酸中毒發(fā)生的危險因素，警示臨床工作。 方法 回顧性分析2008年5月—2010年12月收治的32例乳酸性酸中毒患者的臨床資料?！〗Y果 32例患者均合并2型糖尿病，其中老年患者27例（占84.6%）；20例有服用雙胍類降糖藥物史（占62.5%）；12例合并肺部疾?。ㄕ?7.5%）；9例合并心臟疾?。ㄕ?8.1%）；15例合并腎功能不全（占46.9%）；8例合并肝功能異常（占25.0%）?！〗Y論 糖尿病、老年、使用雙胍類藥物、合并心肺疾病及肝腎功能不全都是發(fā)生乳酸性酸中毒的危險因素。在臨床工作中，對高?；颊咝杼岣呔瑁M量避免危險因素疊加以減少乳酸性酸中毒的發(fā)生。【Abstract】 Objective To analyze the risk factors of lactic acidosis. Methods The clinical data of 32 patients with lactic acidosis admitted to our hospital from May 2008 to December 2010 were studied retrospectively. Results All patients had type 2 diabetes mellitus. Among them, 27 (84.6%) were older than 60, 20 (62.5%) had ingested antidiabetic drugs of biguanides, 12 (37.5%) were complicated by pulmonary diseases, 9 (28.1%) by heart diseases, 15 (46.9%) by renal dysfunction, and 8 (25.0%) by liver dysfunction. Conclusions Diabetes mellitus, old age, ingesting of biguanides, cardiopulmonary diseases, renal and hepatic dysfunction all contribute to the occurrence of lactic acidosis. During clinical work, we should try to avoid the above-mentioned risk factors.