【摘要】 目的 探討血栓性血小板減少性紫癜（thrombotic thrombocytopenic purpura，TTP）患者血管內(nèi)皮損傷程度，以及不同類型TTP之間血管內(nèi)皮損傷差異性?！》椒ā〖{入2005年4月-2010年12月特發(fā)性TTP患者17例（A組），繼發(fā)性TTP患者15例（B組），骨髓移植相關(guān)TTP患者2例（C組），疑似TTP患者11例（D組），共45例；另選取健康體檢志愿者為對(duì)照組10例（E組）。采用雙夾心酶聯(lián)免疫吸附試驗(yàn)測(cè)定血管性血友病因子前肽（von Willebrand factor propeptide，vWFpp）水平?！〗Y(jié)果 vWFpp水平為其與正常混合血漿的比值， A組為2.2，B組為2.34，C組為2.795，D組為1.72，E組為1.08。A、B、C、D組患者vWFpp水平與E組比較，差異有統(tǒng)計(jì)學(xué)意義（Plt;0.05），A、B、C、D組間比較，差異無(wú)統(tǒng)計(jì)學(xué)意義（Pgt;0.05）?！〗Y(jié)論 TTP患者vWFpp水平明顯增高，提示血管內(nèi)皮損傷明顯，但vWFpp水平不能用于鑒別TTP類型?！続bstract】 Objective To explore the severity of endothelium injury in patients with thrombotic thrombocytopenic purpura (TTP) and the differences among different subtypes of TTP. Methods The clinical data of 45 patients with TTP diagnosed between April 2005 and December 2010 were retrospectively analyzed. von Willebrand factor propeptide (vWFpp) was measured by sandwich ELISA in 17 patients with idiopathic TTP (group A), 15 patients with secondary TTP (group B), 2 patients with transplantation associated TTP (group C), 11 patients with suspected TTP (group D) and 10 control healthy volunteers (group E). Results Median times of vWFpp of the five groups were 2.2, 2.34, 2.795, 1.72, and 1.08 respectively. Plasma vWFpp levels of the first four groups didn′t differ much between each other (Plt;0.05), but the differences were significant compared with the data in the control group (Pgt;0.05). Conclusions Significantly increased vWFpp level in patients with TTP indicates obvious endothelium injury. Nevertheless, it could not be used to differentiate TTP types.