【摘要】 目的 研究ΔNP63/TAP63在上皮性卵巢腫瘤組織中的表達(dá)及其與臨床病理特征的關(guān)系。 方法 運(yùn)用熒光定量聚合酶鏈反應(yīng)方法檢測(cè)2002年-2004年54例卵巢上皮性腫瘤中ΔNP63/TAP63的基因水平?！〗Y(jié)果 33例卵巢上皮細(xì)胞癌組織中ΔNP63的表達(dá)高于21例良性上皮性腫瘤中組織。卵巢上皮細(xì)胞癌中的表達(dá)強(qiáng)度與腫瘤組織病理學(xué)分期相關(guān)（Plt;0.05），良性腫瘤的表達(dá)低于惡性腫瘤（Plt;0.05）。ΔNP63的表達(dá)高于TAP63（Plt;0.05）；各組間TAP63的表達(dá)差異無(wú)統(tǒng)計(jì)學(xué)意義（Pgt;0.05）?！〗Y(jié)論 ΔNP63在上皮性卵巢癌中高表達(dá)，可能成為上皮性卵巢癌診斷及預(yù)后的分子標(biāo)志物?！続bstract】 Objective To explore the expression of ΔNP63 / TAP63 in human epithelial ovarian tumor tissues and its relationship with the clinicopathological features. Methods Fluorescent quantitative PCR method was used to detect 54 cases of ΔNP63 / TAP63 gene level in 54 patients with epithelial ovarian tumors diagnosed between 2002 and 2004. Results ΔNP63 expression in the 33 cases of ovarian epithelial cell carcinoma was higher than that in the 21 cases of benign epithelial tumor tissue. The expression in ovarian epithelial cell carcinoma was concerned with the pathological staging of tumor (Plt;0.05); the expression in benign tumors was lower than that in the malignant tumors (Plt;0.05). In all cases, the expression of ΔNP63 was higher than that of TAP63 (Plt;0.05); the difference in the expression of TAP63 among the groups was not significant (Pgt;0.05). Conclusion ΔNP63 in epithelial ovarian cancer is highly expressed, which may become the molecular makers with diagnosis and prognosis of epithelial ovarian cancer diagnosis in the future.