【摘要】 目的 比較利多卡因不同劑量預(yù)處理對羅庫溴銨注射痛的影響。 方法 120例行全身麻醉擇期手術(shù)的患者按照完全隨機的方法分為利多卡因10 mg 3 mL預(yù)處理組（A組），利多卡因25 mg 3 mL預(yù)處理組（B組），利多卡因50 mg 3 mL預(yù)處理組（C組），生理鹽水3 mL預(yù)處理組（D組）。觀察不同劑量的利多卡因預(yù)處理對羅庫溴銨注射痛的影響。 結(jié)果 A、B、C和D組注射羅庫溴銨的疼痛發(fā)生率分別為53%、27%、3%和90%。與生理鹽水預(yù)處理組相比，利多卡因預(yù)處理組能明顯減輕羅庫溴銨引起的注射痛（Plt;0.01）；劑量越大，效果越明顯。 結(jié)論 利多卡因10、25、50 mg預(yù)處理均能顯著降低羅庫溴銨注射時引起的疼痛，以50 mg利多卡因更為有效。【Abstract】 Objective To compare the effects of different doses of lidocaine pretreatment on the pain from injection with rocuronium. Methods One hundred and twenty patients of general anesthesia had undergone elective surgery, were randomly divided into lidocaine 10 mg 3 mL pretreated group (group A), lidocaine 25 mg 3 mL pretreated group (group B), lidocaine 50 mg 3 mL pretreated group (group C) and saline 3 mL pretreated group (group D). The effects of different doses of lidocaine pretreatment on injection pain of rocuronium were observed. Results The pain incidence from injection with rocuronium in A, B, C, D groups were 53%, 27%, 3% and 90% respectively. The higher dose of lidocaine, the more obvious effect. Conclusion Lidocaine pretreatment with 10, 25, 50 mg can reduce the severity of pain from injection with rocuronium, and lidocaine 50 mg is the most effective.