精神障礙與糖尿病之間相互作用機(jī)制復(fù)雜，涉及遺傳、內(nèi)分泌代謝、炎癥反應(yīng)、氧化應(yīng)激等多個(gè)方面，導(dǎo)致精神障礙合并糖尿病患者治療難度大。此類患者現(xiàn)多采用藥物及非藥物干預(yù)方式來(lái)緩解精神障礙癥狀和改善血糖水平，但目前對(duì)精神障礙與糖尿病的作用機(jī)制還需要系統(tǒng)性的概括及切實(shí)可行的干預(yù)手段。該文從糖尿病發(fā)病機(jī)制談起，詳細(xì)敘述了精神分裂癥、雙相情感障礙及抑郁癥與糖尿病的交互作用機(jī)制，總結(jié)了精神障礙合并糖尿病患者的干預(yù)措施，旨在為從事相關(guān)工作的醫(yī)務(wù)人員提供參考。
摘要:目的: 觀察免費(fèi)治療社區(qū)精神分裂癥患者的療效。 方法 :納入貧困家庭精神分裂癥患者140例,隨機(jī)分為免費(fèi)服藥組和對(duì)照組,每組70例。隨訪1年,采用精神分裂癥陽(yáng)性與陰性癥狀量表(PANSS)\社會(huì)功能缺陷量表(SDSS)等評(píng)估。 結(jié)果 :對(duì)實(shí)驗(yàn)組與對(duì)照組的基線、6個(gè)月后及1年后隨訪的PANSS總分、各因子分、SDSS總分分別進(jìn)行比較,結(jié)果顯示基線、6月后均無(wú)統(tǒng)計(jì)學(xué)差異;1年后SDSS總分、PANSS總分、陽(yáng)性因子分、一般病理因子、思維障礙、偏執(zhí)因子分差異有顯著性;免費(fèi)治療組1年后各指標(biāo)與入組前相比分值降低(P＜001)。 結(jié)論 :精神分裂癥患者免費(fèi)服藥后精神癥狀緩解明顯,同時(shí)其社會(huì)功能缺陷也得到改善。Abstract: Objective: To observe the effect of the free treatment on schizophrenics from community. Methods : Totally 140 subjects from poor family were divided into the free treated group and the control group at random. They were followed up for 1 year. The treatment effects were evaluated by PANSS and SDSS. Results : There were no significant difference in all examinations at baseline and after 6 months; at the following end point, significant difference existed in the score of SDSS, the total scores of the PANSS, the positive factor, the general pathology factor, the thinking factor and the paranoid ideation factor between two groups. There was decrease in the scores for all examinations in the free treated group. Conclusion : The symptoms of schizophrenics by free treatment relieve significantly, and the social function improves.