【摘要】 目的 探討125I粒子植入治療中晚期胰腺癌的臨床并發(fā)癥及相關護理措施?！》椒ā』仡櫡治?006年10月-2010年4月121例行125I粒子植入治療的胰腺癌患者的臨床治療及護理，采取積極有效的護理措施，預防及處理并發(fā)癥，促進患者康復。 結果 121例患者接受放射性125I粒子植入治療后，7例出現(xiàn)胰瘺，13例出現(xiàn)胃腸道反應，經對癥處理和精心護理后均治愈?！〗Y論 125I粒子組織間植入近距離治療中晚期胰腺癌近期療效好、安全、副反應少，良好的護理對改善中晚期胰腺癌患者預后具有重要意義。【Abstract】 Objective To observe the complications in patients with middle and advanced pancreatic carcinoma due to treatment of 125I particle implantation, and the investigate the proper nursing methods. Methods The clinical data including the therapy and nursing methods for the complications in 121 patients with middle and advanced pancreatic carcinoma due to treatment of 125I particle implantation from October 2006 to October 2010 were retrospectively analyzed. The treatment and care for complication were analyzed. Results In the 121 patients who had been treated by 125I particle, pancreatic fistula occurred in seven, and severe gastrointestinal upset was found in 13. The patients with the complications recovered after postoperative treatment and nursing. Conclusion 125I particle implantation for patients with middle and advanced pancreatic carcinoma is effective and safe with a few side reactions; proper nursing is important to improve the prognosis.
目的 建立人中分化結腸腺癌細胞裸鼠皮下移植瘤模型，以探討碘-125（125I）粒子治療中分化結腸腺癌的有效性。方法 將人中分化結腸腺癌細胞（SW480）種植到雄性BALB/c-nu/nu裸小鼠皮下，建立動物模型，用隨機抽簽法隨機將荷瘤裸小鼠分成對照組和實驗組（每組24只）,對照組植入1顆空白粒子，實驗組植入1顆劑量為1.48×107 Bq的125I粒子，觀察粒子植入后瘤體生長情況，分別于植入后第7、14、21及28天處死實驗組與對照組荷瘤裸小鼠，每個時相6只裸小鼠。剝取瘤體，分別用于免疫組化SP法測定增殖細胞核抗原(PCNA)的表達，原位末端標記(TUNEL)法檢測腫瘤細胞凋亡情況。結果 隨著放射時間的延長，從第10天起實驗組腫瘤體積明顯小于對照組(Plt;0.05)，從第14天開始PCNA標記指數(shù)表達顯著低于對照組(Plt;0.05)，從第21天開始凋亡指數(shù)顯著高于對照組(Plt;0.05)。結論 125I粒子通過持續(xù)低劑量輻射后可以下調PCNA的表達，誘導人中分化結腸腺癌細胞凋亡增加，是其抑制人中分化結腸腺癌增殖可能的生物學機理之一。