【摘要】 目的 探討降高血壓藥物聯(lián)合抗焦慮抑郁藥物萬拉法新治療老年性原發(fā)高血壓伴焦慮抑郁障礙的療效及安全性。 方法 納入2006年10月-2008年10月我院門診和住院診治的老年性原發(fā)高血壓伴焦慮抑郁障礙患者100例,隨機分為干預(yù)組和對照組。所有患者給予常規(guī)降壓藥物治療,干預(yù)組另外給予萬拉法新治療,治療12周后評價臨床療效。結(jié)果 干預(yù)組臨床降壓療效總有效率940%,顯著高于對照組總有效率800%(Plt;005)。兩組患者的收縮壓、舒張壓與治療前比較均顯著改善(Plt;005),干預(yù)組患者與對照組比較血壓明顯改善(Plt;005)。干預(yù)組臨床抗焦慮抑郁療效總有效率960%,顯著高于對照組總有效率580%(Plt;005)。兩組均無明顯的不良反應(yīng)。結(jié)論 降高血壓藥物聯(lián)合抗焦慮抑郁藥物萬拉法新治療老年性原發(fā)高血壓伴焦慮抑郁障礙療效肯定,且安全可靠,值得臨床推廣應(yīng)用。【Abstract】 Objective To investigate the efficacy and safety of antihypertensive drugs combined with antianxiety depression drug venlafaxine for treatment of patients with senile primary hypertension (SPH) and anxietydepression disorder (AD). Methods One hundred SPH patients with AD with were randomly divided into an intervention group and a control group. All cases were given antihypertensive drugs medication,while the intervention group was given venlafaxine. After 12 weeks of treatment,the clinical efficacy was evaluated. Results The antihypertensive efficacy rate in the intervention group was 940%,significantly higher than that of the control group 800% (Plt;005). The systolic blood pressure(SBP)and diastolic blood pressure (DBP) of the two groups significantly improved compared with those before treatment (Plt;005), and the intervention group’ SBP and DBP improved significantly than those of the control group (Plt;005). The total effective rate of antianxiety depression efficacy of the intervention group was 960%, significantly higher than that of the control group 580% (Plt;005). The two groups had no significant adverse reactions. Conclusion For patients with senile primary hypertension and anxietydepression disorder,the combination medication with antihypertensive drugs and venlafaxine was safe,reliable and worthy of clinical application.