【摘要】 中介素(intermedin,IMD)又稱腎上腺髓質(zhì)素2,是降鈣素基因相關(guān)肽超家族的一員。IMD能夠無選擇性作用于降鈣素受體樣受體/受體活化修飾蛋白復(fù)合物,通過受體復(fù)合物上G蛋白的變構(gòu),激活下游的效應(yīng)酶及離子通道,再進一步發(fā)揮生物學(xué)效應(yīng)。IMD的作用廣泛,其對血管的作用主要包括血管生成作用、外周血管擴張作用、中樞升壓作用及抗血管鈣化作用;其對心臟的作用主要包括正性肌力作用、正性頻率作用、抗心肌肥厚的作用等。
目的調(diào)查醫(yī)院介入手術(shù)室醫(yī)務(wù)人員職業(yè)暴露及防護情況,為制定職業(yè)危害性防護措施提供依據(jù)。 方法2014年9月-11月采用問卷調(diào)查方式對九〇三醫(yī)院介入手術(shù)室共46名醫(yī)務(wù)人員的職業(yè)暴露和防護情況進行調(diào)查,調(diào)查完成后分析調(diào)查問卷并評分。 結(jié)果該醫(yī)院介入手術(shù)室醫(yī)務(wù)工作人員對職業(yè)暴露情況及職業(yè)防護的知曉率均較低,醫(yī)生、護士、放射技師的平均知曉率分別為74.2%、63.0%、66.7%。介入手術(shù)室醫(yī)生、護士及放射技師3組人群實施職業(yè)防護措施的總體情況較差,醫(yī)生、護士、放射技師平均為51.3%、43.9%、15.2%。 結(jié)論該醫(yī)院介入手術(shù)室工作人員職業(yè)防護知識知曉率和職業(yè)防護措施執(zhí)行率差異較大,醫(yī)護人員較高,而放射技師較低。需要重點加強醫(yī)生及護士的輻射損傷及防護相關(guān)知識的培訓(xùn),以及加強放射技師的臨床知識及醫(yī)源性損傷相關(guān)知識的培訓(xùn),并提高醫(yī)護人員的自我防范意識,從而減少相應(yīng)職業(yè)危害。
【摘要】 目的 分析成都地區(qū)中老年居民脈壓(pulse pressure, PP)及脈壓指數(shù)(pulse presure index,PPI)與高尿酸血癥(hyperuricemia,HUA)的關(guān)系?!》椒ā±?007年5月代謝綜合征研究調(diào)查資料(共1 061人),依據(jù)PP[≤60 mm Hg(1 mm Hg=0.133 kPa)、gt;60 mm Hg]和PPI(≤0.450、gt;0.450)將人群分為正常組及增高組,分析兩組人群尿酸水平及HUA患病率,采用單因素回歸及l(fā)ogistic回歸分析PP及PPI與HUA關(guān)系?!〗Y(jié)果?、貾P/PPI增高組血漿尿酸水平明顯高于PP/PPI正常組,差異有統(tǒng)計學(xué)意義(P=0.000)。②PP/PPI增高組HUA患病率明顯高于PP/PPI正常組,差異有統(tǒng)計學(xué)意義(P=0.026、0.027)。③單因素回歸和logistic回歸分析皆提示PP及PPI與HUA呈正相關(guān)。 結(jié)論 成都地區(qū)PP及PPI與血漿尿酸水平關(guān)系密切,PP/PPI增高可能是HUA的危險因素。【Abstract】 Objective To evaluate the relationship between pulse pressure (PP), pulse pressure index (PPI) and hyperuricemia (HUA) among middle-aged and aged residents in Chengdu. Methods Based on the level of PP [≤60 mm Hg (1 mm Hg=0.133 kPa),gt;60 mm Hg] and PPI (≤0.450,gt;0.450), We divided the 1 061 middle-aged or aged people into normal PP/PPI group and augmented PP/PPI group. All patients came from the survey for metabolic syndrome study in May 2007. We analyzed the distribution of serum uric acid (UA) and HUA, and analyzed the relationship between PP, PPI and HUA by using single-factor and logistic regression analysis. Results The index of UA in the augmented PP/PPI groups was higher than that in the normal groups with a significant difference (P=0.000). The prevalence of HUA in the augmented PP/PPI groups was statistically higher than that in the normal groups (P=0.026, 0.027). Single-factor and logistic regression analysis showed that PP and PPI were both positively correlated to HUA. Conclusion The abnormalities of PP and PPI are closely related to metabolism disorder in Chengdu, and high level of PP or PPI is probably risk factors for HUA.